2022
DOI: 10.1017/s0033291722001842
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Altered developmental trajectories of verbal learning skills in 22q11.2DS: associations with hippocampal development and psychosis

Abstract: Background The cognitive profile in 22q11.2 deletion syndrome (22q11.2DS) is often characterized by a discrepancy between nonverbal vs. verbal reasoning skills, in favor of the latter skills. This dissociation has also been observed in memory, with verbal learning skills described as a relative strength. Yet the development of these skills is still to be investigated. We thus aimed to explore verbal learning longitudinally. Furthermore, we explored verbal learning and its respective associations with hipp… Show more

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Cited by 6 publications
(11 citation statements)
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“…Analysis of hippocampal tail volume relationships to IQ suggests that this region may be particularly related to verbal cognition in 22qDel but not 22qDup or TD. This broadly supports the recent finding of hippocampal tail volume relationships with verbal learning scores in 22qDel [27]. Our analysis was specifically motivated by this prior literature; however, this effect would not have remained significant after correction for multiple comparisons in an exploratory analysis of cognition relationships to all subregional volumes.…”
Section: Discussionsupporting
confidence: 83%
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“…Analysis of hippocampal tail volume relationships to IQ suggests that this region may be particularly related to verbal cognition in 22qDel but not 22qDup or TD. This broadly supports the recent finding of hippocampal tail volume relationships with verbal learning scores in 22qDel [27]. Our analysis was specifically motivated by this prior literature; however, this effect would not have remained significant after correction for multiple comparisons in an exploratory analysis of cognition relationships to all subregional volumes.…”
Section: Discussionsupporting
confidence: 83%
“…Analysis of hippocampal tail volume relationships to IQ suggests that this region may be particularly related to verbal cognition in 22qDel but not 22qDup or TD. This broadly supports the recent finding of hippocampal tail volume relationships with verbal learning scores in 22qDel [27].…”
Section: Gene Dosage Effectssupporting
confidence: 91%
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“…Verbal memory in 22q11.2DS is differentially characterized in the literature, with some studies suggesting it as a relative strength and others documenting pronounced deficits. While Woodin et al [9] and Lajiness-O'Neill et al [38] indicate that verbal memory is significantly less impacted than visuospatial memory, research by Maeder et al [29] and Latrèche et al [39] depicts a less optimistic picture, finding significant challenges in both immediate and delayed verbal memory. In combination, these deficits in both immediate and delayed verbal memory suggest a pattern of forgetting that may point to an impaired process of memory consolidation [29].…”
Section: Language Processing Abilitiesmentioning
confidence: 99%