Altered Dynamic Amplitude of Low-Frequency Fluctuations in Patients With Migraine Without Aura

Abstract

Migraine is a chronic and idiopathic disorder leading to cognitive and affective problems. However, the neural basis of migraine without aura is still unclear. In this study, dynamic amplitude of low-frequency fluctuations (dALFF) analyses were performed in 21 patients with migraine without aura and 21 gender- and age-matched healthy controls to identify the voxel-level abnormal functional dynamics. Significantly decreased dALFF in the bilateral anterior insula, bilateral lateral orbitofrontal cortex, bilateral medial prefrontal cortex, bilateral anterior cingulate cortex, and left middle frontal cortex were found in patients with migraine without aura. The dALFF values in the anterior cingulate cortex were negatively correlated with pain intensity, i.e., visual analog scale. Finally, support vector machine was used to classify patients with migraine without aura from healthy controls and achieved an accuracy of 83.33%, sensitivity of 90.48%, and specificity of 76.19%. Our findings provide the evidence that migraine influences the brain functional activity dynamics and reveal the neural basis for migraine, which could facilitate understanding the neuropathology of migraine and future treatment.

Altered Brain Functional Network Dynamics in Classic Trigeminal Neuralgia: A Resting-state Functional Magnetic Resonance Imaging Study

“…One recent rs-fMRI study of chronic migraine revealed disrupted negative FC between DMN and CC of patients [51]. Another study investigated migraine brain using dynamic amplitude of low-frequency uctuations (dALFF) also found decreased dynamics in both DMN and CC [53]. In the present study, the higher occurrence of a state with obvious FC between DMN and CC may indicate that state as a neural substrate for the dysregulation of static FC between networks in CTN.…”

Alteration in Functional Magnetic Resonance Imaging Signal Complexity Across Multiple Time Scales in Patients With Migraine Without Aura

“…The medial orbitofrontal, as the key node in the DMN, is involved in the cognitive aspects of pain processing and top-down modulation of pain ( Schwedt et al, 2015 ). Our results provide more detail on the DMN anomaly hypothesis of migraines ( Tessitore et al, 2013 ; Zou et al, 2019 ; Chen et al, 2021 ) and that these abnormalities vary over time in migraineurs. The postcentral gyrus, paracentral lobule, and parietal gyrus are important parts of the sensorimotor network ( Quairiaux et al, 2011 ), which is closely related to pain and is the main pain-regulating central system ( Bornhovd et al, 2002 ; Liu et al, 2021 ).…”

“…Traditionally, brain dynamic activity has been mainly explored based on measuring the mean or variance of the sequence ( Chen et al, 2021 ; Lim et al, 2021 ) in a single time scale. These methods often overlooked the importance of the interaction among numerous neuronal circuits over a wide range of temporal and spatial scales, which is the basis of the brain to adapt to the ever-changing environment and to perform various mental functions ( Yang et al, 2015 ; Wang et al, 2019 ).…”

Altered brain functional network dynamics in classic trigeminal neuralgia: a resting-state functional magnetic resonance imaging study

“…One recent rs-fMRI study on chronic migraine revealed disrupted negative FC between the DMN and CC of patients [ 58 ]. Another study investigated the migraine brain using dynamic amplitude of low-frequency fluctuations (dALFF) and found decreased dynamics in both DMN and CC [ 60 ]. In the present study, the higher occurrence of a state with obvious FC between DMN and CC may indicate the state is a neural substrate for the dysregulation of static FC between networks in CTN.…”