Altered effective connectivity between reward and inhibitory control networks in people with binge eating episodes: A spectral dynamic causal modeling study

Chen, Ximei; Li, Wei; Liu, Yong; Xiao, Mingzhao; Chen, Hong

doi:10.1016/j.appet.2023.106763

Cited by 4 publications

(1 citation statement)

References 59 publications

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“…Thus, this study would further quantify the EC of mOFC and lOFC among the three groups by using spectral dynamic causal modeling (spDCM), a reliable approach widely applied in psychopathology, which could identify the direction of connections and the valence of connections (excitatory versus inhibitory) between key brain regions ( Fonzo et al., 2021 ; Friston et al., 2014 ; Li et al., 2020 ; Razi et al., 2015 ). To date, spDCM has been used to reveal the direction of connectivity that contribute to emotional intelligence ( Bajaj & Killgore, 2021 ), binge eating ( Chen et al., 2023 ), obesity ( Voigt et al., 2021 ), and clinical outcomes (e.g., focal dystonia and major depressive disorder) ( Battistella & Simonyan, 2019 ; Li et al., 2020 ). Given the functional heterogeneity of mOFC and lOFC (as mentioned above), and given the strong relationship of dysfunctional eating (e.g., binge eating and overeating) with potential interaction between brain's reward and cognitive control systems (e.g., Chen et al., 2021 ; Oliva et al., 2020 ; Shapiro et al., 2019 ), we further assumed that (iii) bulimic individuals might exhibit altered connectivity between these two OFC subregions (e.g., an inhibitory effect from the mOFC to lOFC).…”

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confidence: 99%

Altered connectivity patterns of medial and lateral orbitofrontal cortex underlie the severity of bulimic symptoms

Li,

Chen,

Luo

et al. 2024

International Journal of Clinical and Health Psychology

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Section: Introductionmentioning

confidence: 99%

Altered connectivity patterns of medial and lateral orbitofrontal cortex underlie the severity of bulimic symptoms

Li,

Chen,

Luo

et al. 2024

International Journal of Clinical and Health Psychology

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Reward and Inhibitory Control as Mechanisms and Treatment Targets for Binge Eating Disorder

Pasquale,

Boyar,

Boutelle

2024

Curr Psychiatry Rep

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Purpose of Review Recent research has highlighted alterations in reward and inhibitory control among individuals with binge eating disorder, identifying both constructs as potential targets for treatment. Treatments targeting reward and inhibitory control for binge eating disorder are emerging. This review aims to summarize the recent literature evaluating reward and inhibitory control in binge eating disorder compared to weight-matched controls using behavioral paradigms and neuroimaging. This review also aims to summarize recent literature evaluating treatments for binge eating targeting these mechanisms and highlights additional work needed in these areas. Recent Findings Reward hypersensitivity and impaired inhibitory control are mechanisms underlying binge eating disorder. Individuals with binge eating disorder experience higher initial reward to food, and later, higher anticipatory reward but lower experienced food reward which maintains binge eating behavior. Treatments targeting reward and inhibitory control for binge eating include behavioral, computerized trainings, pharmacological, and neuromodulation treatments. The majority of trials are small but demonstrate promise in reducing binge eating and targeting theorized mechanisms. Larger, randomized trials are needed. Summary Changes in reward and inhibitory control are present in individuals with binge eating disorder and treatments targeting these mechanisms demonstrate initial promise. Greater research is needed evaluating reward and inhibitory control simultaneously and with weight-matched comparison groups, as well as larger randomized trials that target both processes simultaneously.

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Changes in functional connectivity and structural covariance between the fronto-parietal network and medial orbitofrontal cortex are associated with disinhibition in restrained eaters

Wang,

Han,

Xiao

et al. 2024

Cerebral Cortex

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Disinhibition, characterized by a loss of dietary control, is a significant risk factor for diet failure and the onset of eating disorders in restrained eaters. This study employs resting-state functional connectivity and structural covariance network analyses to explore the neural associations underlying this behavior. By analyzing functional MRI data from 63 female college students, we found that increased disinhibition correlates with enhanced functional connectivity between the medial orbitofrontal cortex and key components of the inhibition system, particularly within the fronto-parietal network. Moreover, we observed a relationship between the structural covariance of the medial orbitofrontal cortex and the inferior parietal lobule and the severity of disinhibition. Importantly, the functional connectivity between the medial orbitofrontal cortex and the inferior parietal lobule predicts the severity of binge eating symptoms in these individuals. These findings indicate that imbalances in the interaction between the brain’s reward and inhibition systems can lead to dietary failures and eating disorders, emphasizing the need for targeted interventions.

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Altered effective connectivity between reward and inhibitory control networks in people with binge eating episodes: A spectral dynamic causal modeling study

Cited by 4 publications

References 59 publications

Altered connectivity patterns of medial and lateral orbitofrontal cortex underlie the severity of bulimic symptoms

Altered connectivity patterns of medial and lateral orbitofrontal cortex underlie the severity of bulimic symptoms

Reward and Inhibitory Control as Mechanisms and Treatment Targets for Binge Eating Disorder

Changes in functional connectivity and structural covariance between the fronto-parietal network and medial orbitofrontal cortex are associated with disinhibition in restrained eaters

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