Altered endocannabinoid metabolism compromises the brain-CSF barrier and exacerbates chronic deficits after traumatic brain injury in mice

Ahluwalia, Meenakshi; Mcmichael, Hannah; Kumar, Manish; Espinosa, Mario P; Bosomtwi, Asamoah; Lu, Yujiao; Khodadadi, Hesam; Jarrahi, Abbas; Khan, M. Badruzzaman; Hess, David C.; Rahimi, Scott Y.; Vender, John R.; Vale, Fernando Ĺ.; Braun, Molly; Baban, Babak; Dhandapani, Krishnan M.; Vaibhav, Kumar

doi:10.1016/j.expneurol.2023.114320

Experimental Neurology

2023

DOI: 10.1016/j.expneurol.2023.114320

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Altered endocannabinoid metabolism compromises the brain-CSF barrier and exacerbates chronic deficits after traumatic brain injury in mice

Meenakshi Ahluwalia

Hannah Mcmichael

Manish Kumar

et al.

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Cited by 8 publications

References 126 publications

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Aquaporin 4 and the endocannabinoid system: a potential therapeutic target in brain injury

Martínez-Torres,

Morán

2024

Exp Brain Res

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Brain edema is a critical complication arising from stroke and traumatic brain injury (TBI) with an important impact on patient recovery and can lead to long-term consequences. Therapeutic options to reduce edema progression are limited with variable patient outcomes. Aquaporin 4 (AQP4) is a water channel that allows bidirectional water diffusion across the astrocyte membrane and participates in the distinct phases of cerebral edema. The absence or inhibition of this channel has been demonstrated to ameliorate edema and brain damage. The endocannabinoid system (ECS) is a neuromodulator system with a wide expression in the brain and its activation has shown neuroprotective properties in diverse models of neuronal damage. This review describes and discusses the major features of ECS and AQP4 and their role during brain damage, observing that ECS stimulation reduces edema and injury size in diverse models of brain damage, however, the relationship between AQP4 expression and dynamics and ECS activation remains unclear. The research on these topics holds promising therapeutic implications for the treatment of brain edema following stroke and TBI.

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Aquaporin 4 and the endocannabinoid system: a potential therapeutic target in brain injury

Martínez-Torres,

Morán

2024

Exp Brain Res

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Single episode of moderate to severe traumatic brain injury leads to chronic neurological deficits and Alzheimer’s-like pathological dementia

Vaibhav,

Gulhane,

Ahluwalia

et al. 2024

GeroScience

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AGEING RESEARCH REVIEWS (ARR-D-24-01334R1) Metabolic dysfunction contributes to mood disorders after traumatic brain injury

Liu,

Jia,

Liu

et al. 2024

Ageing Research Reviews

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Altered endocannabinoid metabolism compromises the brain-CSF barrier and exacerbates chronic deficits after traumatic brain injury in mice

Cited by 8 publications

References 126 publications

Aquaporin 4 and the endocannabinoid system: a potential therapeutic target in brain injury

Aquaporin 4 and the endocannabinoid system: a potential therapeutic target in brain injury

Single episode of moderate to severe traumatic brain injury leads to chronic neurological deficits and Alzheimer’s-like pathological dementia

AGEING RESEARCH REVIEWS (ARR-D-24-01334R1) Metabolic dysfunction contributes to mood disorders after traumatic brain injury

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