Altered energy metabolism after myocardial infarction assessed by 31 P-MR-spectroscopy in humans

Beer, Meinrad; Sandstede, J.; Landschütz, W; Viehrig, Marén; Harre, Kerstin; Horn, Michael; Meininger, Martin; Pabst, Thomas; Kenn, W.; Haase, Axel; Kienlin, Markus von; Neubauer, Stefan; Hahn, Dietbert

doi:10.1007/s003300000316

Cited by 28 publications

(18 citation statements)

References 23 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Another problem is the impossibility to calculate PCr/ATP ratios from voxels, which do not contain any PCr signal amplitudes. Authors Beer et al [64] therefore used the signal-to-noise ratio of ATP as an indirect measurement for ATP content in patients with anterior myocardial infarction. Thus, they observed a significant reduction of ATP in patients with scar tissue.…”

Section: Normal Valuesmentioning

confidence: 99%

“…neither PCr nor ATP peaks detectable for the anterior region. This patient showed no recovery of regional function after revascularization and was classified as having non-viable tissue; modified according to [64] Multiple sclerosis Another multisystemic neurological disease with a suspected cardiac involvement is MS. Whether MS, in addition to CNS involvement, structurally affects the heart is under debate [79,80].…”

Section: Myopathiesmentioning

confidence: 99%

See 1 more Smart Citation

Cardiac spectroscopy: techniques, indications and clinical results

Beer¹

2004

European Radiology

View full text Add to dashboard Cite

Cardiac MR spectroscopy allows the non-invasive assessment of metabolic processes. In contrast to numerous experimental applications, the clinical use of MRS is still restricted to specialized centers of expertise. However, during the last 10 years, several technical improvements as well as new clinical applications have been introduced, which might change this fact. This article focuses on (1) these recent technical advances such as reproducible quantification methods and dedicated data acquisition as well as postprocessing methods, (2) outlines emerging clinical indications and (3) summarizes available clinical studies. Basic principles of cardiac metabolism are presented, and discussed in the context of recent clinical papers. Finally, the impact of the new highest-field magnets--3 T and beyond--is discussed under the perspectives for the future clinical role of MR spectroscopy.

show abstract

Section: Normal Valuesmentioning

confidence: 99%

Section: Myopathiesmentioning

confidence: 99%

Cardiac spectroscopy: techniques, indications and clinical results

Beer¹

2004

European Radiology

View full text Add to dashboard Cite

show abstract

“…The signal-to-noise ratio (SNR) of PCr and γ-ATP were calculated also using "AMARES" [19]. Noise was determined via the standard deviation of the last 100 points of the FID signal [6].…”

Section: P-mr-spectroscopymentioning

confidence: 99%

“…Most of the studies have shown reductions of energy metabolites [4], which correspond to fixed defects in nuclear studies [5] or persistent wall motion abnormalities (WMA), despite revascularization procedures [6]. However, these results are conflicted by other studies, which show only minor or no changes of energetics after MI [7].…”

Section: Introductionmentioning

confidence: 99%

Energetic differences between viable and non-viable myocardium in patients with recent myocardial infarction are not an effect of differences in wall thinning— a multivoxel 31P-MR-spectroscopy and MRI study

et al. 2006

View full text Add to dashboard Cite

To evaluate multivoxel (31)P-MR spectroscopy (MRS) for assessment of energy metabolism in patients with myocardial infarction (MI) in correlation to left ventricular (LV) wall thickness and the outcome of revascularization. Thirty patients with subacute anterior myocardial infarction and planned revascularization were enrolled. 3D-chemical shift imaging was applied to determine PCr/ATP ratios in two areas: infarcted/anterior and noninfarcted/septal myocardium. MRI was used to evaluate LV function and wall thickness, and was repeated 6 months after revascularization to assess myocardial viability. Fifteen volunteers were controls. Fifteen patients showed normalization of wall motion abnormalities after revascularization (Group 1; viable), 15 not (Group 2; non-viable). Regarding infarcted/anterior myocardium, Group 2 had lower PCr/ATP ratios (0.81 +/- 0.60 vs 1.17 +/- 0.25), and PCr/ATP ratios were reduced in both groups compared to controls (1.45 +/- 0.29). Regarding noninfarcted/septal myocardium, again Group 2 had lower ratios (0.93 +/- 0.53 vs 1.31 +/- 0.38); however, compared to controls (1.51 +/- 0.32) a reduction of PCr/ATP ratios was only found in Group 2. For both myocardial regions, no correlations between PCr/ATP ratios and LV wall thickness were detected. The more severe energetic alteration in irreversibly damaged myocardium is not an effect of differences of wall thinning. Additional alterations of noninfarcted, adjacent myocardium can be detected.

show abstract

“…Hence, the myocardial PCr/ATP ratio determined using 31 P-MRS is used to evaluate patients with cardiac disease [6,7,8,9,10]. …”

Section: Introductionmentioning

confidence: 99%

The Relationship between Plasma BNP Level and the Myocardial Phosphocreatine/Adenosine Triphosphate Ratio Determined by Phosphorus-31 Magnetic Resonance Spectroscopy in Patients with Dilated Cardiomyopathy

Chida

Otani²,

Kohzuki

et al. 2006

Cardiology

View full text Add to dashboard Cite

The purpose of this study was to evaluate the correlation between the plasma B-type natriuretic peptide (BNP) level and the myocardial phosphocreatine/adenosine triphosphate ratio determined using rapid phosphorus-31 magnetic resonance spectroscopy (³¹P-MRS) in patients with dilated cardiomyopathy (DCM). Thirteen DCM patients, who had slight or moderate heart failure, were examined. The plasma BNP was measured on a day close to the rapid ³¹P-MRS study. ³¹P-MRS measurements were conducted with a 1.5-T MR instrument. The plasma BNP levels tended to be correlated negatively with the myocardial phosphocreatine/adenosine triphosphate, although the correlation did not reach statistical significance (r = –0.54, p =0.06). By contrast, the log of the plasma BNP levels was correlated negatively with the myocardial phosphocreatine/adenosine triphosphate (r = –0.73, p < 0.01). Our results indicate that the myocardial energy metabolism evaluated using ³¹P-MRS tends to be correlated with the severity of heart failure and left ventricular dysfunction estimated using the plasma BNP levels in DCM patients. This paper provides additional information regarding the relationship between the BNP and myocardial energy metabolism in DCM patients.

show abstract

Altered energy metabolism after myocardial infarction assessed by 31 P-MR-spectroscopy in humans

Cited by 28 publications

References 23 publications

Cardiac spectroscopy: techniques, indications and clinical results

Cardiac spectroscopy: techniques, indications and clinical results

Energetic differences between viable and non-viable myocardium in patients with recent myocardial infarction are not an effect of differences in wall thinning— a multivoxel 31P-MR-spectroscopy and MRI study

The Relationship between Plasma BNP Level and the Myocardial Phosphocreatine/Adenosine Triphosphate Ratio Determined by Phosphorus-31 Magnetic Resonance Spectroscopy in Patients with Dilated Cardiomyopathy

Contact Info

Product

Resources

About