Altered Expression of MBNL Family of Alternative Splicing Factors in Colorectal Cancer

Disturbance of the human gut microbiota in patients with Myotonic Dystrophy type 1

“…While our results are limited to a very small cohort and used only amplicon sequencing (which can at best illustrate the active, dormant, and inactive bacterial taxa at the genus level), our findings show changes in the gut microbiota composition in DM1 patients that are in line with bacterial communities that have been detected in patients with cancer. Furthermore, many research works have suggested that patients with DM1 are at increased risk of cancer progression in various locations, including the colon [88] , endometrium, ovary, brain [89] , and possibly cutaneous melanoma and thyroid cancer [90.] , [91.]…”

Cancer in myotonic dystrophy: A new discovery in an old disease

“…In addition, the dysregulation of RNA-binding muscleblind-like proteins in DM1 and DM2 has been recently described in several cancers, including glioblastoma and colorectal cancer. 19,20 Supportive and symptom-oriented therapies are the mainstay of DM treatment, but ongoing clinical trials, particularly for DM1, are Abbreviations: CNBP, CCHC-type zinc finger nucleic acid binding protein; DM, myotonic dystrophy; DMPK, dystrophia myotonica-protein kinase; SIR, standardized incidence ratio.…”

“…Other areas of molecular overlap between DM and cancer include the genetic defect that involves DMPK in DM1, which is member of a family of kinases responsible for other cancer susceptibility syndromes such as RET in multiple endocrine neoplasia type 2, and RAF1 in Noonan syndrome. In addition, the dysregulation of RNA‐binding muscleblind‐like proteins in DM1 and DM2 has been recently described in several cancers, including glioblastoma and colorectal cancer 19,20 …”