Altered expression of TPP1 in fibroblast-like synovial cells might be involved in the pathogenesis of rheumatoid arthritis

Qing, Yufeng; Zhou, Jingguo; Zhao, Ming; Yang, Qidong; Xing, Yan; Zeng, Sheng-ping; Jiang, Hong

doi:10.1007/s00296-011-1992-x

Cited by 10 publications

(4 citation statements)

References 47 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The TPP1 gene is one of the top network genes and ranked the first on GS. TPP1 gene was associated with rheumatoid arthritis (RA) [21], which suggested that TPP1 may be a potential candidate gene for T1D, as T1D and RA were reported to have some common susceptibility loci [22]. In addition, TPP1 may indirectly influence metabolism possibly by regulating telomere length [23].…”

Section: Resultsmentioning

confidence: 99%

“…As described above, TPP1 and SKAP2 showed co-expression relationship with each other, thus TPP1 may be also associated with T1D. A study of RA has found that decreasing expression of TPP1 was observed in RA patients and it had a negative correlation with autoantibodies [21]. T1D and RA are two auto-immunity disease and were reported to share some susceptibility loci, such as SKAP2 [22].…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

System network analysis of genomics and transcriptomics data identified type 1 diabetes-associated pathway and genes

Chen

et al. 2018

Genes Immun

View full text Add to dashboard Cite

Genome-wide association studies (GWASs) have discovered >50 risk loci for type 1 diabetes (T1D). However, those variations only have modest effects on the genetic risk of T1D. In recent years, accumulated studies have suggested that gene–gene interactions might explain part of the missing heritability. The purpose of our research was to identify potential and novel risk genes for T1D by systematically considering the gene–gene interactions through network analyses. We carried out a novel system network analysis of summary GWAS statistics jointly with transcriptomic gene expression data to identify some of the missing heritability for T1D using weighted gene co-expression network analysis (WGCNA). Using WGCNA, seven modules for 1852 nominally significant (P ≤ 0.05) GWAS genes were identified by analyzing microarray data for gene expression profile. One module (tagged as green module) showed significant association (P ≤ 0.05) between the module eigengenes and the trait. This module also displayed a high correlation (r = 0.45, P ≤ 0.05) between module membership (MM) and gene significant (GS), which indicated that the green module of co-expressed genes is of significant biological importance for T1D status. By further describing the module content and topology, the green module revealed a significant enrichment in the “regulation of immune response” (GO:0050776), which is a crucially important pathway in T1D development. Our findings demonstrated a module and several core genes that act as essential components in the etiology of T1D possibly via the regulation of immune response, which may enhance our fundamental knowledge of the underlying molecular mechanisms for T1D.

show abstract

Section: Resultsmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

System network analysis of genomics and transcriptomics data identified type 1 diabetes-associated pathway and genes

Chen

et al. 2018

Genes Immun

View full text Add to dashboard Cite

show abstract

“…17 Similar finding are suggested by various studies done so far. 5,18,19,20,21,22,23 Increased levels of the ferritin causes formation of the free radicals, which damages cellular organelles, especially mitochondria. 9 This impairs β-oxidation of fatty acids in mitochondria.…”

Section: Discussionmentioning

confidence: 99%

Correlation between levels of serum ferritin and lipid profile status.

Rahman

Khan

Rahman

et al. 2020

TPMJ

View full text Add to dashboard Cite

Objectives: To analyse the correlation between ferritin level in serum and lipid profile in patients presenting to a Tertiary Care Centre. Study Design: Cross Sectional Descriptive study. Setting: Khyber Teaching Hospital Peshawar. Period: 1st January 2019 to 31st July 2019. Material & Methods: About 60 patients presenting to the laboratory referred for serum lipid profile or serum ferritin were included in the study. Sampling was done by purposive non probability technique. Blood was taken from patients in gel tube. Serum ferritin levels and lipid profile were done in all cases. Lipid profile included serum cholesterol, triglyceride level, low density lipoprotein and high density lipoproteins. The levels were recorded in a proforma. The serum ferritin level was correlated with the lipid profile status in all patient and the results were drawn accordingly. Results: About 60 patients were analysed. The mean age was 20.8± 5.2 years (range: 2 years to 60 years). There were 39 (65%) males and 21(35%) females. Out of 60 cases, serum ferritin level was normal, increased and lower in 15(25%), 40(66.6%) and 5 (8.3%) cases respectively. The cases where serum ferritin was abnormally raised, the significant changes in lipid profile were raised cholesterol and raised triglyceride (in 62.5% and 82.5% cases respectively). Conclusion: There is an association between raised serum ferritin and raised serum cholesterol level and serum triglyceride levels. This supports the link between serum ferritin regulation and lipid metabolism in the body. As dyslipidemia is a major cardiovascular risk factor. Therefore, a raised ferritin level must alert the physician about lipid profile of the patient and should prompt the physician to think about preventive measures against cardiovascular events in order to decrease the morbidity and mortality in patients at risk.

show abstract

“…TPP-1 may not only be a promising target for further research in the field of neurology. Some recent studies show a potential role of this particle in the pathogenesis of rheumatoid arthritis, as TPP-1 altered expression in fibroblast-like synovial cells was associated with development of this rheumatic disease [ 10 ].…”

Section: Discussionmentioning

confidence: 99%

The paediatric rheumatologist and orphan disease – a story without happy ending

2016

View full text Add to dashboard Cite

Orphan diseases are not a common challenge in the everyday practice of the rheumatologist. Despite their extremely rare occurrence one of the patients under our care developed one of them – neuronal ceroid lipofuscinosis, the most frequent neurodegenerative disease observed in the paediatric population. We report a case of 2-year-old girl diagnosed with oligoarticular form of juvenile idiopathic arthritis treated in our Department with steroids and methotrexate and staying in the stage of disease remission. During routine checkups at Outpatient Clinic we observed progressive deterioration of girls neurological condition resulting in ataxia, gait disturbances with no rheumatological cause behind and speech impairment. The appearance of the symptoms was accompanied by frequent episodes of epileptic seizures, with little clinical improvement on combined antiepileptic treatment. Magnetic resonance imaging that we performed showed a picture highly suggestive of neuronal ceroid lipofuscinosis – atrophy of the patients cerebrum and cerebellum. Genetic testing conducted resulted in the diagnosis of late infantile neuronal ceroid lipofuscinosis (LINCL).

show abstract

Altered expression of TPP1 in fibroblast-like synovial cells might be involved in the pathogenesis of rheumatoid arthritis

Cited by 10 publications

References 47 publications

System network analysis of genomics and transcriptomics data identified type 1 diabetes-associated pathway and genes

System network analysis of genomics and transcriptomics data identified type 1 diabetes-associated pathway and genes

Correlation between levels of serum ferritin and lipid profile status.

The paediatric rheumatologist and orphan disease – a story without happy ending

Contact Info

Product

Resources

About