Altered expressions of peripheral CD11c, CD80, CD83 markers and associations of HLA class II allele and haplotypes in self-limiting Hepatitis E infection

Das, Rumki; Rathod, Sanjay; Alagarasu, Kalichamy; Arankalle, Vidya A.; Tripathy, Anuradha S.

doi:10.1016/j.humimm.2012.12.010

Cited by 7 publications

(4 citation statements)

References 29 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…As HEV replicates through dsRNA intermediate and TLR3 gets activated by dsRNA, the possibility of limited replication of HEV in PBMCs cannot be ruled out. Several direct and indirect evidences suggest that gene expression is altered in PBMC's in response to HEV infection (Srivastava et al, 2008;Saravanabalaji et al, 2009;Das et al, 2013;Jagya et al, 2014;Ramdasi et al, 2014;Arya and Arankalle, 2014). The gene expression changes in UTR interacting proteins and their associated proteins will provide insights in molecular mechanisms therefore; the interactome map of UTR binding proteins was retrieved using data mining approach.…”

Section: Discussionmentioning

confidence: 99%

Identification and characterization of cellular proteins interacting with Hepatitis E virus untranslated regions

Paingankar

Arankalle

2015

Virus Research

Self Cite

View full text Add to dashboard Cite

Section: Discussionmentioning

confidence: 99%

Identification and characterization of cellular proteins interacting with Hepatitis E virus untranslated regions

Paingankar

Arankalle

2015

Virus Research

Self Cite

View full text Add to dashboard Cite

“…Further, acute hepatitis E infection is reported to be associated with a reversible alteration in the proportions and activation status of the peripheral NK/NKT cells and NK subsets [13]. Elevation of peripheral CD11c, HLA DR, CD11c/CD86, and HLADR/CD86 expressions in the acute hepatitis E patients with viral load has suggested involvement of these cells [14]. An increased expression of the CD11a integrin in naïve CD45RA + T cells and overexpression of CCR5 and CCR9 during AVH-E infection have suggested an enhanced recruitment of these cells from periphery to the target tissue during the early phase of infection.…”

Section: Discussionmentioning

confidence: 99%

“…In the same context, in vitro data on peripheral blood mononuclear cells (PBMCs) proliferation and HEV-specific T cells producing Th 2 cytokine suggest a role of CD4 + T lymphocytes in HEV infection [5, 13]. Reports from our group and others suggest the involvement of both T cell subsets and antigen nonspecific cells in self-limiting HEV infection [6, 7, 13, 14]. We have recently reported peripheral CD11c, CD80, and CD83 expressions to be high in hepatitis E patients, CD11c expression to be positively associated with HEV replication [14], and association of T regulatory (Treg) cells in acute HEV infection [8].…”

Section: Introductionmentioning

confidence: 98%

“…Reports from our group and others suggest the involvement of both T cell subsets and antigen nonspecific cells in self-limiting HEV infection [6, 7, 13, 14]. We have recently reported peripheral CD11c, CD80, and CD83 expressions to be high in hepatitis E patients, CD11c expression to be positively associated with HEV replication [14], and association of T regulatory (Treg) cells in acute HEV infection [8]. Higher expressions of CTLA-4, PD1, GITR, CD95, CD103, and CD73 on T regulatory and T effector cells of HEV patients have indicated probable involvement of these molecules in Treg-mediated suppression [9].…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Hepatitis E rORF2p Stimulated and Unstimulated Peripheral Expression Profiling in Patients with Self-Limiting Hepatitis E Infection

Rathod

Tripathy

2014

Journal of Immunology Research

Self Cite

View full text Add to dashboard Cite

To improve the current knowledge on the involvement of peripheral lymphocytes in hepatitis E virus (HEV) associated pathogenesis, we analyzed alterations in (1) immunophenotypic expressions (by flow cytometry) and (2) gene expression patterns (by TaqMan Low Density Array) of activatory, inhibitory, integrin, homing, ectonucleotidase machinery, costimulatory, inflammatory markers, and T regulatory cells (Treg) associated cytokines on HEV rORF2p stimulated and unstimulated PBMCs of 43 acute HEV patients, 30 recovered individuals, and 43 controls. The phenotypic expressions of key molecules CTLA-4, GITR, CD103, CD25, CD69, IL10 and TGF-β 1 in the acute patients and TGF-β 1 in the recovered individuals were significantly elevated on both unstimulated and stimulated PBMCs. Gene expression array data revealed upregulations of CD25, PD1, CD103, CCR4, IL10, and TGF-β 1 on both unstimulated and HEV rORF2p stimulated PBMCs of acute patients. The observed upregulations of inhibitory, integrin, activatory, and Treg-associated cytokine genes on the PBMCs of acute HEV patients complemented by their frequency data suggest them as the major players in the fine-tuning of immune response in self-limiting hepatitis E infection.

show abstract

Increased expressions of NKp44, NKp46 on NK/NKT-like cells are associated with impaired cytolytic function in self-limiting hepatitis E infection

Das

Tripathy

2014

Med Microbiol Immunol

View full text Add to dashboard Cite

We have characterized the NK/NKT-like cells in patients with self-limiting hepatitis E infection. The distribution of peripheral NK/NKT-like cells, expressions of activation receptors, cytotoxic potential and effector function of NK/NKT-like cells from fresh peripheral blood mononuclear cells of 86 acute patients, 101 recovered and 54 control individuals were assessed. Activated NKT-like (CD16(+) CD56(+) CD3(+)) cells were high in the patient groups. On CD56(+) CD3(-) cells, NKp44 and NKp46 expressions were high in the acute patients, whereas NKp30, NKp44, NKp46 and NKG2D were high in the recovered individuals. On CD56(+) CD3(+) cells, NKp44, NKp46 and NKG2D expressions were high in the recovered but NKp30 was low in both the patient groups. Collectively, the current study elucidates the role of NK/NKT-like cells demonstrating phenotypic alterations of activated NKT-like cells and activation receptors, lack of CD107a expression and functional impairment of peripheral NK/NKT-like cells in self-limiting hepatitis E infection.

show abstract

Altered expressions of peripheral CD11c, CD80, CD83 markers and associations of HLA class II allele and haplotypes in self-limiting Hepatitis E infection

Cited by 7 publications

References 29 publications

Identification and characterization of cellular proteins interacting with Hepatitis E virus untranslated regions

Identification and characterization of cellular proteins interacting with Hepatitis E virus untranslated regions

Hepatitis E rORF2p Stimulated and Unstimulated Peripheral Expression Profiling in Patients with Self-Limiting Hepatitis E Infection

Increased expressions of NKp44, NKp46 on NK/NKT-like cells are associated with impaired cytolytic function in self-limiting hepatitis E infection

Contact Info

Product

Resources

About