Altered Flow-Mediated Vasodilatation, Low Paraoxonase-1 Activity, and Abnormal High-Density Lipoprotein Subclass Distribution in Takayasu's Arteritis

Espínola‐Zavaleta, Nilda; Soto, Marí­a Elena; Carreón‐Torres, Elizabeth; Gamboa, Ricardo; Mejía, Ana María; Márquez-Velasco, Ricardo; Bojalil, Rafael; Huesca-Gómez, Claudia; Reyes, Pedro A.; Pérez-Méndez, Óscar

doi:10.1253/circj.cj-08-0582

Cited by 22 publications

(16 citation statements)

References 43 publications

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“…In combination with endothelial dysfunction, these abnormalities are likely to be important in the accelerated atherosclerosis in TA. 18,19 In the present study the severity of luminal narrowing in carotid arteries was positively correlated with degree of dyssynchronous expansion. These findings could support the relationship between abnormal arterial mechanical property and luminal narrowing in patients with TA.…”

Section: Vascular Alteration In Takayasu's Arteritissupporting

confidence: 58%

Assessment of Mechanical Properties of Common Carotid Artery in Takayasu's Arteritis Using Velocity Vector Imaging

Cho

Shim

Yang

et al. 2010

Circ J

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Section: Vascular Alteration In Takayasu's Arteritissupporting

confidence: 58%

Assessment of Mechanical Properties of Common Carotid Artery in Takayasu's Arteritis Using Velocity Vector Imaging

Cho

Shim

Yang

et al. 2010

Circ J

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“…Although most studies showed decreased FMD in systemic vasculitis patients, one study showed that there was an enhanced FMD in patients with systemic vasculitis (19) where they had postulated that continued endothelial activation, even when the disease was clinically quiescent, could have led to this response. Unlike the results reported by Espinola-Zavaleta et al, (20) endothelial function as measured by FMD was found to be similar between patients with TA and normal controls (p>0.05). Hoffmann et al (21) showed that the efficacy of infliximab in TA patients acts by inhibiting the action of TNF-β, thereby decreasing iNOS activity.…”

Section: Discussioncontrasting

confidence: 99%

Assessment of Endothelial Function in Patients with Takayasu Arteritis by Measuring Flow-Mediated Vasodilation and Correlating it with Plasma Levels of Reactive Nitrogen Intermediates

Senguttuvan¹,

Jain²,

Rajendran³

et al. 2019

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A B S T R A C T BACKGROUNDTakayasu arteritis (TA) is the most common cause of renovascular hypertension in young Asians. We wanted to assess endothelial function in patients with TA using flow-mediated vasodilation (FMD) and its correlation with plasma levels of reactive nitrogen intermediates (RNI). METHODSTwenty patients with TA and 20 age-and sex-matched controls were studied. After obtaining informed consent, a detailed clinical examination and appropriate laboratory investigations were performed to assess disease activity (active and inactive groups as per American College of Rheumatologists criteria), FMD (measured as per the guidelines) and levels of RNI were measured. RESULTSThe mean RNI level of patients with TA was 22.54 μM, which was significantly higher than that of controls (5.53 μM) (p<0.0001). The mean RNI level in patients with active disease (16 of 20 patients) was 26.97±17.43 μM, which was significantly higher than their counterparts in remission (12.21±11.82 μM). However, the post hoc analysis of RNI levels did not demonstrate any statistically significant difference between patients with inactive disease and controls (p= 0.36). The mean FMD in patients with TA was found to be 25.72% compared with 24.83% in controls (p>0.05). CONCLUSIONSEndothelial function, as measured by FMD, showed no difference between patients with TA and controls; however, mean RNI level was significantly elevated in patients with TA. Interestingly, patients with active TA had significantly higher RNI levels than those with inactive disease.

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“…3,28,29 Moreover, TA patients had more endothelial dysfunction, lower paroxonase-1 activity, a higher proportion of large HDL2b and lower levels of HDL3b than in hypertensive patients and controls. 30 In clinical practice, the search for risk factors for CVD should not be overlooked in TA patients. Even though corticosteroid and immunosuppressive therapy was not associated with a protection against ischemic events in the present study, we believe that the proper treatment of TA disease activity is also important for preventing ischemic events altogether with aspirin use and the management of risk factors for CVD.…”

Section: De Souza Aws Et Almentioning

confidence: 99%

Antiplatelet Therapy for the Prevention of Arterial Ischemic Events in Takayasu Arteritis

Souza

Machado

Pereira

et al. 2010

Circ J

110

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Background: Vessel wall inflammation, atherosclerosis and hypercoagulability may be responsible for ischemic events in Takayasu arteritis (TA). No study has evaluated the effect of antiplatelet therapy for the prevention of ischemic events in TA. Methods and Results:Forty-eight patients who met the ACR Classification Criteria for TA under follow-up at the Vasculitis Unit of Universidade Federal de São Paulo were evaluated retrospectively for clinical manifestations, therapy and arterial ischemic events. The mean age at study was 38.0 years and the mean age at TA diagnosis was 29.1 years. Women comprised for 89.6% of patients and 60.4% were Caucasian. Risk factors for cardiovascular disease were found in 44 patients (91.7%) The most common comorbidities for TA patients were hypertension (77.1%), high low-density lipoprotein (45.8%) and obesity (16.7%). Antiplatelet therapy was used by 62.5% of patients whereas anticoagulants were used by 12.5%. Acute ischemic events occurred in 29.2% of patients. TA patients with ischemic events used significantly less antiplatelet agents (14.3%) than those without ischemic events (82.4%), P<0.0001. No difference concerning ischemic events was observed in patients on anticoagulant therapy (P=0.339). The 3 deaths of TA patients were observed only in those who had presented ischemic events (P=0.021). Antiplatelet agents had a protective effect against ischemic events (hazard ratio =0.055, 95% confidence interval: 0.06-0.514; P=0.011). Conclusions:Antiplatelet therapy is associated with a lower frequency of ischemic events in patients with TA. Antiplatelet Therapy in Takayasu Arteritis review of medical records of forty-eight patients who fulfilled the 1990 American College of Rheumatology criteria for TA and were under regular follow-up at the Vasculitis Unit in the Universidade Federal de São Paulo (Unifesp). 13 All of the 52 TA patients registered at our Vasculitis Unit were screened for this study, but 4 of them had to be excluded due to incomplete medical records. Medical appointments were scheduled within every one to 3 months in order to evaluate patients for the activity and progression of TA. Blood samples were collected before each visit for complete blood counts, erythrocyte sedimentation rates, lipid profiles, fasting glucose, liver enzymes and renal function. The decision to prescribe aspirin was made by the assistant physician. Statins were prescribed when serum low-density lipoprotein (LDL) levels exceeded 130 mg/dl.The present study was approved by the Institutional Ethics Committee. We collected information about demographic characteristics, disease features, arteriographic classification of TA, risk factors for cardiovascular diseases (CVD), acute ischemic events and medication used by the patients, including corticosteroids, immunosuppressive drugs, statins, anticoagulant and antiplatelet therapy. 14 The commencement dates for antiplatelet and anticoagulant therapy and of acute ischemic events were collected carefully. Time since the onset of symptoms suggestive o...

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Altered Flow-Mediated Vasodilatation, Low Paraoxonase-1 Activity, and Abnormal High-Density Lipoprotein Subclass Distribution in Takayasu's Arteritis

Cited by 22 publications

References 43 publications

Assessment of Mechanical Properties of Common Carotid Artery in Takayasu's Arteritis Using Velocity Vector Imaging

Assessment of Mechanical Properties of Common Carotid Artery in Takayasu's Arteritis Using Velocity Vector Imaging

Assessment of Endothelial Function in Patients with Takayasu Arteritis by Measuring Flow-Mediated Vasodilation and Correlating it with Plasma Levels of Reactive Nitrogen Intermediates

Antiplatelet Therapy for the Prevention of Arterial Ischemic Events in Takayasu Arteritis

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