Altered free amino acid levels in brain cortex tissues of mice with Alzheimer's disease as their N(O,S)-ethoxycarbonyl/tert-butyldimethylsilyl derivatives

Paik, Man‐Jeong; Cho, In-Seon; Mook‐Jung, Inhee; Lee, Gwang; Kim, Kyoung-Rae

doi:10.5483/bmbrep.2008.41.1.023

Cited by 10 publications

(7 citation statements)

References 38 publications

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“…Altered amino acid levels in the brain have been linked with neurodegeneration [76]. Here too, we observed a significant alteration in the levels of amino acids such as alanine, proline, glycine, valine, and isoleucine in the brain of PQ-exposed organism.…”

Section: Discussionsupporting

confidence: 56%

Metabolomic Analysis Provides Insights on Paraquat-Induced Parkinson-Like Symptoms in Drosophila melanogaster

Shukla

Pragya

et al. 2014

Mol Neurobiol

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Paraquat (PQ) exposure causes degeneration of the dopaminergic neurons in an exposed organism while altered metabolism has a role in various neurodegenerative disorders. Therefore, the study presented here was conceived to depict the role of altered metabolism in PQ-induced Parkinson-like symptoms and to explore Drosophila as a potential model organism for such studies. Metabolic profile was generated in control and in flies that were fed PQ (5, 10, and 20 mM) in the diet for 12 and 24 h concurrent with assessment of indices of oxidative stress, dopaminergic neurodegeneration, and behavioral alteration. PQ was found to significantly alter 24 metabolites belonging to different biological pathways along with significant alterations in the above indices. In addition, PQ attenuated brain dopamine content in the exposed organism. The study demonstrates that PQ-induced alteration in the metabolites leads to oxidative stress and neurodegeneration in the exposed organism along with movement disorder, a phenotype typical of Parkinson-like symptoms. The study is relevant in the context of Drosophila and humans because similar alteration in the metabolic pathways has been observed in both PQ-exposed Drosophila and in postmortem samples of patients with Parkinsonism. Furthermore, this study provides advocacy towards the applicability of Drosophila as an alternate model organism for pre-screening of environmental chemicals for their neurodegenerative potential with altered metabolism.

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Section: Discussionsupporting

confidence: 56%

Metabolomic Analysis Provides Insights on Paraquat-Induced Parkinson-Like Symptoms in Drosophila melanogaster

Shukla

Pragya

et al. 2014

Mol Neurobiol

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“…We report similar concentrations of MI, Asp, CR, Cho, GABA, and PC to those previously reported [29–34]. In contrast, our concentrations of Gln and Tau were about 5-fold lower than previous reports [33, 35], whereas, NAA and Glu were 2.5-fold higher than what was reported in previous studies [30, 31]. The differences in endogenous levels of AAs reported from the various studies could be due to degradation of AAs during sample extraction due to residual enzymatic activity, different analytical procedures used, age, gender, and/or the number of mice used in the study.…”

Section: Resultssupporting

confidence: 87%

“…The differences in endogenous levels of AAs reported from the various studies could be due to degradation of AAs during sample extraction due to residual enzymatic activity, different analytical procedures used, age, gender, and/or the number of mice used in the study. In addition, one study [31] quantified AAs in specific regions of brain such as the cortex rather than the whole brain.…”

Section: Resultsmentioning

confidence: 99%

Rapid and reliable quantitation of amino acids and myo-inositol in mouse brain by high performance liquid chromatography and tandem mass spectrometry

Bathena

Huang

Epstein

et al. 2012

Journal of Chromatography B

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“…Amino acid and organic acid pro ling and pattern recognition AA analysis was performed by using a previous method [57,58]. Brie y, 0.5 ml aliquots from the petal or ovary were adjusted to pH ≥ 12 with 5.0 M NaOH and diluted with 0.5 mL distilled water and 0.1 mg of norvaline as internal standard.…”

Section: Strawberry Petal and Ovary Samples For Exudate Analysismentioning

confidence: 99%

Glutamic Acid Reshapes The Phytobiome To Protect Plants Against Pathogens

Kim¹,

Jeon²,

Cho³

et al. 2020

Preprint

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Background: The physiology and growth of plants are strongly influenced by their associated microbiomes. Conversely, the composition of the phytobiome is flexible, responding to the state of the host and raising the possibility that it can be engineered to benefit the plant. However, technology for engineering the structure of the microbiome is not yet available.Results: Here we show that glutamic acid reshapes the plant microbial community and enriches populations of Streptomyces, a functional core microbe, both above and below ground, in strawberry and tomato. Upon application of glutamic acid, the population size of Streptomyces increased dramatically in the anthosphere and the rhizosphere. At the same time, diseases caused by species of Fusarium were significantly reduced in both habitats. Plant resistance-related genes were not activated, suggesting that glutamic acid modulates the microbiome community directly, rather than activating the host’s own protective mechanisms.Conclusions: Much is known about the structure of plant-associated microbial communities, but little has been learned about how the community composition and complexity are controlled. Our results demonstrate that the microbiome community can be engineered and unlock the mode of action of glutamic acid.

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Altered free amino acid levels in brain cortex tissues of mice with Alzheimer's disease as their N(O,S)-ethoxycarbonyl/tert-butyldimethylsilyl derivatives

Cited by 10 publications

References 38 publications

Metabolomic Analysis Provides Insights on Paraquat-Induced Parkinson-Like Symptoms in Drosophila melanogaster

Metabolomic Analysis Provides Insights on Paraquat-Induced Parkinson-Like Symptoms in Drosophila melanogaster

Rapid and reliable quantitation of amino acids and myo-inositol in mouse brain by high performance liquid chromatography and tandem mass spectrometry

Glutamic Acid Reshapes The Phytobiome To Protect Plants Against Pathogens

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