Altered functional connectivity within and between the default model network and the visual network in primary open-angle glaucoma: a resting-state fMRI study

Wang, Jieqiong; Li, Ting; Zhou, Peng; Wang, Ke; Xian, Junfang; He, Hong

doi:10.1007/s11682-016-9597-3

Cited by 31 publications

(34 citation statements)

References 47 publications

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“…In addition, several studies have reported functional compensation in the POAG brain with increased functional connectivities between normally functioning regions. 28 , 29 The increased small-world index and nodal efficiency may also be attributed to functional compensation.…”

Section: Discussionmentioning

confidence: 99%

Data-Driven Parcellation Approaches Based on Functional Connectivity of Visual Cortices in Primary Open-Angle Glaucoma

Wang

Tang

et al. 2020

Invest. Ophthalmol. Vis. Sci.

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Purpose Functional changes have been observed between diseased and healthy subjects, and functional brain atlases derived from healthy populations may fail to reflect functional characteristic of the diseased brain. Therefore the aim of this study was to generate a visual atlas based on functional connectivity from primary open-angle glaucoma (POAG) patients and to prove the applicability of the visual atlas in functional connectivity and network analysis. Methods Functional magnetic resonance images were acquired from 36 POAG patients and 20 healthy controls. Two data-driven approaches, K-means and Ward clustering algorithms, were adopted for visual cortices parcellation. Dice coefficient and adjusted Rand index were used to assess reproducibility of the two approaches. Homogeneity index, silhouette coefficient, and network properties were adopted to assess functional validity for the data-driven approaches and frequently used brain atlas. Graph theoretical analysis was adopted to investigate altered network patterns in POAG patients based on data-driven visual atlas. Results Parcellation results demonstrated asymmetric patterns between left and right hemispheres in POAG patients compared with healthy controls. In terms of evaluating metrics, K-means performed better than Ward clustering in reproducibility. Data-driven parcellations outperformed frequently used brain atlases in terms of functional homogeneity and network properties. Graph theoretical analysis revealed that atlases generated by data-driven approaches were more conducive in detecting network alterations between POAG patients and healthy controls. Conclusions Our findings suggested that POAG patients experienced functional alterations in the visual cortices. Results also highlighted the necessity of data-driven atlases for functional connectivity and functional network analysis of POAG brain.

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Section: Discussionmentioning

confidence: 99%

Data-Driven Parcellation Approaches Based on Functional Connectivity of Visual Cortices in Primary Open-Angle Glaucoma

Wang

Tang

et al. 2020

Invest. Ophthalmol. Vis. Sci.

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“…Chen et al demonstrated that glaucoma patients displayed abnormal brain activity in the visual pathway 19. The dysfunction of the intra- and interconnectivity in the visual network and default model network has been observed in glaucoma patients 20. Structural magnetic resonance imaging (MRI) and DTI methods have been applied to detect the altered cerebral structure in visual cortices and visual pathway.…”

Section: Introductionmentioning

confidence: 99%

<p>Frequency-dependent neural activity in primary angle-closure glaucoma</p>

Jiang

Chen

Zuo

et al. 2019

NDT

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ObjectiveIn this study, we aimed to investigate the frequency-dependent spontaneous neural activity in primary angle-closure glaucoma (PACG) using the amplitude of low-frequency fluctuations (ALFF) method.Patients and methodsIn total, 52 PACG individuals (24 males and 28 females) and 52 normal-sighted controls (NS; 24 males and 28 females) who were closely matched in age, sex, and education underwent resting-state magnetic resonance imaging scans. A repeated-measures ANOVA and post hoc two-sample t-tests were conducted to analyze the different ALFF values in two different frequency bands (slow-4, 0.027–0.073 Hz and slow-5, 0.010–0.027 Hz) between the two groups. Pearson’s correlation analysis was conducted to reveal the relationship between the mean ALFF values and clinical variables in the PACG group.ResultsCompared to the NS group, the PACG group had high ALFF values in the right inferior occipital gyrus and low ALFF values in the left middle occipital gyrus, left precentral gyrus, and left postcentral gyrus in the slow-4 band. The PACG group had high ALFF values in the right inferior occipital gyrus and low ALFF values in the left inferior parietal lobule, left postcentral gyrus, and right precentral/postcentral gyrus in the slow-5 band. Specifically, we found that the abnormal ALFF values in the bilateral posterior cingulate gyrus and bilateral precuneus were higher in the slow-4 than in the slow-5 band, whereas ALFF in the bilateral frontal lobe, right fusiform, and right cerebellum posterior lobe were higher in the slow-5 than in the slow-4 band. The greater mean ALFF values of the right inferior occipital gyrus were associated with smaller retinal nerve fiber layer thickness and greater visual fields in PACG group in the slow-4 band.ConclusionOur results highlighted that individuals in the PACG group showed abnormal spontaneous neural activities in the visual cortices, sensorimotor cortices, frontal lobe, frontoparietal network, and default mode network at two frequency bands, which might indicate impaired vision and cognition and emotion function in PACG individuals. These findings offer important insight into the understanding of the neural mechanism of PACG.

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“…37 The same changes in brain function have been observed in eye diseases. Investigators illustrated that the FC of the cuneus decreased in glaucoma, 8,16,7,16 acute open globe injury, 17 and monocular blindness. 15 Consistent with these previous studies, in the present study, we detected a significant reduction in FC between the bilateral V1 and bilateral cuneus, indicating the severity of NVG and visual quality.…”

Section: Discussionmentioning

confidence: 99%

<p>Altered Intrinsic Functional Connectivity of the Primary Visual Cortex in Patients with Neovascular Glaucoma: A Resting-State Functional Magnetic Resonance Imaging Study</p>

Wu¹,

Wang²,

Zhu³

et al. 2020

NDT

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The purpose was to investigate the differences in spontaneous functional connectivity (FC) of the primary visual cortex (V1) between patients with neovascular glaucoma (NVG) and healthy controls (HCs) using resting-state functional magnetic resonance imaging data. Methods: A total of 18 patients with NVG (nine males and nine females) and 18 HCs with similar age and sex background were enrolled in the study and inspected using resting-state functional magnetic resonance imaging. The differences in FC of the V1 between the two groups were compared using the independent samples t-test. We used the receiver operating characteristic (ROC) curve to compare the average FC values of NVG subjects with those of HCs. Results: FC in the left V1 and right fusiform gyrus, bilateral cuneus, and left precuneus was significantly decreased in the NVG group compared with that reported in the HC group. Meanwhile, patients with NVG presented increased FC between the right V1 and bilateral middle frontal gyrus. However, they also exhibited declining FC between the right V1 and left precuneus, and bilateral cuneus. The ROC curve analysis of each brain region indicated that the accuracy of the area under the ROC curves regarding NVG was excellent. Conclusion: NVG involves aberrant FC in the V1 in different brain areas, including the visual-related and cognitive-related regions. These findings may assist in unveiling the underlying neural mechanisms of impaired visual function in NVG.

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Altered functional connectivity within and between the default model network and the visual network in primary open-angle glaucoma: a resting-state fMRI study

Cited by 31 publications

References 47 publications

Data-Driven Parcellation Approaches Based on Functional Connectivity of Visual Cortices in Primary Open-Angle Glaucoma

Data-Driven Parcellation Approaches Based on Functional Connectivity of Visual Cortices in Primary Open-Angle Glaucoma

<p>Frequency-dependent neural activity in primary angle-closure glaucoma</p>

<p>Altered Intrinsic Functional Connectivity of the Primary Visual Cortex in Patients with Neovascular Glaucoma: A Resting-State Functional Magnetic Resonance Imaging Study</p>

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