Altered glucose metabolism and the invasive tumor phenotype

Ra, Gatenby

doi:10.3892/ijo.8.3.597

Cited by 5 publications

(3 citation statements)

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“…A common feature of cancer cells is their altered glucose metabolism [48,49]. Unlike non-neoplastic cells that rely on oxidative phosphorylation to generate the energy needed for cellular processes, cancer cells can shift their metabolism from respiration towards glycolysis producing lactic acid.…”

Section: Cell Metabolic Plasticitymentioning

confidence: 99%

The biology and mathematical modelling of glioma invasion: a review

Alfonso

Talkenberger

Seifert

et al. 2017

J. R. Soc. Interface.

187

163

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Adult gliomas are aggressive brain tumours associated with low patient survival rates and limited life expectancy. The most important hallmark of this type of tumour is its invasive behaviour, characterized by a markedly phenotypic plasticity, infiltrative tumour morphologies and the ability of malignant progression from low-to high-grade tumour types. Indeed, the widespread infiltration of healthy brain tissue by glioma cells is largely responsible for poor prognosis and the difficulty of finding curative therapies. Meanwhile, mathematical models have been established to analyse potential mechanisms of glioma invasion. In this review, we start with a brief introduction to current biological knowledge about glioma invasion, and then critically review and highlight future challenges for mathematical models of glioma invasion.

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Section: Cell Metabolic Plasticitymentioning

confidence: 99%

The biology and mathematical modelling of glioma invasion: a review

Alfonso

Talkenberger

Seifert

et al. 2017

J. R. Soc. Interface.

187

163

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“…First of all, it allows the generation of side products by removing intermediates from the citric cycle [ 21 ]. Secondly, the production of lactate itself provides a powerful tool for cancer cells: The secretion of lactate to the surrounding tissue leads to an acidification, to which most host cells cannot adapt and therefore die [ 22 , 23 ]. Additionally, an angiogenetic effect of lactate has been shown recently [ 24 ].…”

Section: Targets For Cancer Stratification By Molecular Imagingmentioning

confidence: 99%

Cancer Stratification by Molecular Imaging

Weber

Haberkorn

Mier

2015

IJMS

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The lack of specificity of traditional cytotoxic drugs has triggered the development of anticancer agents that selectively address specific molecular targets. An intrinsic property of these specialized drugs is their limited applicability for specific patient subgroups. Consequently, the generation of information about tumor characteristics is the key to exploit the potential of these drugs. Currently, cancer stratification relies on three approaches: Gene expression analysis and cancer proteomics, immunohistochemistry and molecular imaging. In order to enable the precise localization of functionally expressed targets, molecular imaging combines highly selective biomarkers and intense signal sources. Thus, cancer stratification and localization are performed simultaneously. Many cancer types are characterized by altered receptor expression, such as somatostatin receptors, folate receptors or Her2 (human epidermal growth factor receptor 2). Similar correlations are also known for a multitude of transporters, such as glucose transporters, amino acid transporters or hNIS (human sodium iodide symporter), as well as cell specific proteins, such as the prostate specific membrane antigen, integrins, and CD20. This review provides a comprehensive description of the methods, targets and agents used in molecular imaging, to outline their application for cancer stratification. Emphasis is placed on radiotracers which are used to identify altered expression patterns of cancer associated markers.

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“…Because the tumor consumes more nutrients than normal cells (Gatenby 1996), it is expected that the concentration gradients in the continuous-flow coculture environment will affect the MTS growth. We used the same chip and in Sect 3.2.…”

Section: Mts Growthmentioning

confidence: 99%

Microfluidic effects of transporting signaling components in cell coculture chips

2008

Microfluid Nanofluid

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A theoretical model has been developed to investigate the microfluidic transport of the signaling chemicals in the cell coculture chips. Using an epidermal growth factor (EGF)-like growth factor as the sample chemical, the effects of velocities and channel geometry were studied for the continuous-flow microchannel bioreactors. It is found that different perfusion velocities must be applied in the parallel channels to facilitate the communication, i.e., transport of the signaling component, between the coculture channels. Such communication occurs in a unidirectional way because the signaling chemicals can only flow from the high velocity area to the low velocity area. Moreover, the effect of the transport of the signaling component between the coculture channels on the growth of the monolayer cells and the multicellular tumor spheroid (MTS) in the continuous-flow coculture environment were simulated using 3D models. The numerical results demonstrated that the concentration gradients will induce the heterogeneous growth of the cells and the MTSs, which should be taken into account in designing the continuous-flow perfusion bioreactor for the cell coculture research.

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Altered glucose metabolism and the invasive tumor phenotype

Cited by 5 publications

References 0 publications

The biology and mathematical modelling of glioma invasion: a review

The biology and mathematical modelling of glioma invasion: a review

Cancer Stratification by Molecular Imaging

Microfluidic effects of transporting signaling components in cell coculture chips

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