Altered glucose tolerance in carbon disulfiede exposed workers

Candura, F; Franco, Giuliano; Malamani, T; Piazza, Angelo

doi:10.1007/bf02629120

Cited by 12 publications

(7 citation statements)

References 4 publications

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“…The effect of CS 2 appeared to depend both on the intensity and duration of exposure. Although further studies are necessary to define the mechanisms involved in the pathogenesis of the subclinical impairment of carbohydrate metabolism, the authors suggested that CS 2 may exert a detrimental effect on zinc and pyridoxamine metabolism (Candura et al, 1979). The increased xanthurenic acid production in its turn may cause impaired insulin activity by the formation of a xanthurenic acid–insulin complex.…”

Section: Resultsmentioning

confidence: 99%

Occupational chemical exposure and diabetes mellitus risk

et al. 2016

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Diabetes mellitus (DM) is a group of metabolic diseases that may originate from an interaction between genetic and lifestyle risk factors. However, the possible role of occupational chemical exposures in the disease development and progression remains unclear. Therefore, this review aimed to provide a comprehensive evaluation of the relationship between occupational exposure to specific chemical substances or industrial activities and DM morbidity and mortality outcomes. Although some positive findings may support the diabetogenic role of certain pesticides and dioxins in different workplaces, the variable conditions of exposure, the lack of quantitative environmental or biological monitoring data and the different outcomes evaluated do not allow defining a specific exposure-disease causality. Therefore, further epidemiological studies will be necessary to adequately assess modes of action for different substances, dose-response relationships as well as individual susceptibility factors potentially affecting the exposure-disease continuum. Overall, this appears important to adequately assess, communicate and manage risks in occupational chemical exposure settings with the aim to protect workers and build healthier job conditions for diabetic employees.

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Section: Resultsmentioning

confidence: 99%

Occupational chemical exposure and diabetes mellitus risk

et al. 2016

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“…The noted increase in glycosylated haemoglobin, which is less aVected by diet intake, may support the theory that exposure to CS 2 could aVect glucose metabolism. In studies with workers exposed to CS 2 , a positive prednisolone glucose tolerance test 9 or increased blood glucose concentration and impaired glucose tolerance to oral cortisone 10 were reported. Recently, to the contrary, it has been reported that there was no association between blood glucose concentration and exposure to CS 2 .…”

Section: Discussionmentioning

confidence: 99%

“…2 Subclinical eVectssuch as reduction in the peripheral nerve conduction velocity, neurobehavioural and psychological changes-and increased subjective complaints have been detected with sensitive neurological and psychological techniques at various concentrations of CS 2 including low concentrations of CS 2 of 10-20 ppm or even <10 ppm. [3][4][5][6][7][8] EVects of CS 2 on liver functions 2 or the endocrine system have also been pointed out, including glucose metabolism 9 10 and functions of the adrenal, thyroid, gonad, and the hypothalamo-hypophysial axis. [11][12][13][14][15][16][17] However, few epidemiological studies were prospectively designed to examine the eVects of low level exposure to CS 2 on the nervous and endocrine systems.…”

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confidence: 99%

Cross sectional observation of the effects of carbon disulphide on the nervous system, endocrine system, and subjective symptoms in rayon manufacturing workers.

Takebayashi¹,

Omae²,

Ishizuka³

et al. 1998

Occup Environ Med

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Objectives-A prospective cohort study was initiated to clarify whether the current level of exposure to carbon disulphide (CS 2 ) is low enough to prevent occurrence of subclinical health impairments or to ameliorate health eVects due to past high exposure. This paper describes the eVects of exposure to CS 2 on the nervous and endocrine systems, and the subjective symptoms in a baseline observation. Methods-The eVects were evaluated of CS 2 on the median nerve conduction velocity, neurobehavioural and psychological tests, and subjective symptoms related to solvents in 432 male workers exposed to CS 2 and 402 reference workers from 11 rayon factories in Japan. Adjustment was made for potential confounding factors such as age or alcohol drinking. Exposure to CS 2 was either dichotomised or categorised into three groups by job type. Results-Reductions were observed in motor (-1.9 m/s) and sensory (-0.91 m/s for orthodromic and -1.1 m/s for antidromic) nerve conduction velocities in the workers exposed to CS 2 at the spinning and refining processes. Small but significant increases were found in self rated depression scale score and decrease in digit span (backward) in the workers exposed to CS 2 . Of 54 subjective symptoms many were increased-namely, heavy feeling in the head, light headedness, fainting after suddenly standing up, tremor, dullnes, and increased sensitivity of skin in the extremities, reduced grasping power, reduced sexual desire, and increased rough skin. The endocrinological indicator-the concentration of glycosylated haemoglobin-was also increased in the workers exposed to CS 2 . Conclusions-Subclinical eVects on the nervous system and on glucose metabolism were found in the workers exposed to CS 2 . One interpretation is that relatively higher exposure to CS 2 in the past may induce these, but the eVects are still not entirely ameliorated under the current exposure to CS 2 . Another possibility is that the current exposure to CS 2 may cause these positive findings. A follow up observation is necessary to clarify these questions. (Occup Environ Med 1998;55:473-479)

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“…It has been suggested that CS 2 exposure might affect glucose metabolism; positive results in a prednisolone glucose tolerance test 15) and high blood glucose levels and impaired glucose tolerance to oral cortisone 14) have been reported previously. However, it was more recently reported that no association was observed between blood glucose levels and CS 2 exposure 17,25) .…”

Section: Discussionmentioning

confidence: 99%

“…These discrepancies may be due to differences in various factors such as the degree of exposure, population studied or type of study conducted. Likewise, some authors have suggested that glucose metabolism could be impaired by CS 2 exposure 14,15) , but contradictory null results have also been reported as well 16,17) . In a baseline analysis of this study, glycosylated hemoglobin levels increased in a CS 2 -exposed group compared to a referent group 7) .…”

mentioning

confidence: 99%

Lack of Relationship between Occupational Exposure to Carbon Disulfide and Endocrine Dysfunction: A Six‐year Cohort Study of the Japanese Rayon Workers

Takebayashi

Nishiwaki

Nomiyama

et al. 2003

Journal of Occupational Health

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Lack of Relationship between Occupational Exposure to Carbon Disulfide and Endocrine Dysfunction: A Six-year Cohort Study of the Japanese Rayon Workers: Toru TAKEBAYASHI, et al. Department of Preventive Medicine and PublicHealth, School of Medicine, Keio UniversityObjectives-A six-year prospective cohort study was conducted to clarify whether the current carbon disulfide (CS 2 ) exposure level is low enough to prevent subclinical health impairment and/or to ameliorate health effects due to previous high exposure. This paper describes the follow-up results, exposure assessment, and effects on the endocrine system. Methods-The study subjects were 432 male workers exposed to CS 2 at one of the 11 rayon factories in Japan and 402 referent workers from the same factories, all of whom were examined in 1992-93. 251 CS 2 -exposed, 140 former-exposed and 359 referent workers participated in the follow-up survey (follow-up rate 89.9%) in 1998-99. Urinary 2-thiothiazolidine-4-carboxylic acid (TTCA) at the end of a shift as internal exposure index and the time-weighted average CS 2 concentration as external exposure index were measured twice a year from 1992-1993. By using various blood indices, we evaluated effects on thyroid, hypophysis, and gonad function, as well as effects on glucose metabolism. Information on potential confounding factors, such as age, smoking and alcohol drinking, were collected and adjusted for. ResultsWhen the individual exposure level was represented by arithmetic mean for TTCA and CS 2 concentration, Received July 31, 2002; Accepted Jan 24, 2003 Correspondence to: T. Takebayashi, Department of Preventive Medicine and Public Health, School of Medicine, Keio University, 35 Shinanomachi, Japan geometric means (SD) of CS 2 workers were 1.61 (1.91) mg/g.crea and 5.02 (1.84) ppm, respectively. There were no exposure-related differences in glucose metabolism or any of the endocrinological indices. Conclusions-No biologically significant effects of CS 2 were found on endocrine function in Japanese rayon manufacturing workers when the average internal and external exposure levels were maintained below the current occupational exposure limit. (J Occup Health 2003; 45: 111-118)

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Altered glucose tolerance in carbon disulfiede exposed workers

Cited by 12 publications

References 4 publications

Occupational chemical exposure and diabetes mellitus risk

Occupational chemical exposure and diabetes mellitus risk

Cross sectional observation of the effects of carbon disulphide on the nervous system, endocrine system, and subjective symptoms in rayon manufacturing workers.

Lack of Relationship between Occupational Exposure to Carbon Disulfide and Endocrine Dysfunction: A Six‐year Cohort Study of the Japanese Rayon Workers

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