Altered gut microbiome after bariatric surgery and its association with metabolic benefits: A systematic review

Davies, Naomi; O’Sullivan, Justin M.; Plank, Lindsay D.; Murphy, Rinki

doi:10.1016/j.soard.2019.01.033

Cited by 69 publications

(63 citation statements)

References 44 publications

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“…The taxonomic composition of the gut microbial population is significantly impacted following weight loss surgery ( Table 2). The most common change reported by the majority of animal [69] and human studies [30,[70][71][72][73] is a relative decrease in the abundance of Firmicutes and an increase in Bacteroidetes, Proteobacteria, and its class Gammaproteobacteria (order Enterobacteriales, family Enterobacteriaceae, genus Escherichia). Notably, the GM profile differs significantly between rodents and humans [14].…”

Section: Taxonomical and Functional Alterationsmentioning

confidence: 99%

“…Functional alterations of GM following BS were also explored by a few small-scale studies [62,73,77]. Recent data showed that surgery-related taxonomical changes shaped the functional capacity of microbial populations mostly in the first three months postoperatively [78] and this effect was sustained up to nine years [59].…”

Section: Taxonomical and Functional Alterationsmentioning

confidence: 99%

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Bariatric Surgery in Obesity: Effects on Gut Microbiota and Micronutrient Status

et al. 2020

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Obesity is associated with reduced gut microbial diversity and a high rate of micronutrient deficiency. Bariatric surgery, the therapy of choice for severe obesity, produces sustained weight loss and improvements in obesity-related comorbidities. Also, it significantly alters the gut microbiota (GM) composition and function, which might have an important impact on the micronutrient status as GM is able to synthesize certain vitamins, such as riboflavin, folate, B12, or vitamin K2. However, recent data have reported that GM is not fully restored after bariatric surgery; therefore, manipulation of GM through probiotics represents a promising therapeutic approach in bariatric patients. In this review, we discuss the latest evidence concerning the relationship between obesity, GM and micronutrients, the impact of bariatric surgery on GM in relation with micronutrients equilibrium, and the importance of the probiotics’ supplementation in obese patients submitted to surgical treatment.

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Section: Taxonomical and Functional Alterationsmentioning

confidence: 99%

Section: Taxonomical and Functional Alterationsmentioning

confidence: 99%

Bariatric Surgery in Obesity: Effects on Gut Microbiota and Micronutrient Status

et al. 2020

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“…Bariatric surgery modifies GM composition in the short- [49][50][51] , mid- 44,48,52 and long-term, up to 9 years 8,42 . These bacterial compositional changes have been extensively reviewed in the literature [53][54][55][56] . Interestingly, several bacterial and metabolic signatures have been consistently described, and are described here in Table 1, whereas some bacterial changes have been further associated with clinical parameters, as illustrated in Table 2.…”

Section: Post-bs Evolution Of Gut Microbiota Compositionmentioning

confidence: 99%

Gut Microbiota Dysbiosis in Human Obesity: Impact of Bariatric Surgery

2019

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Purpose of the review: We herein summarize what is currently described in terms of Gut microbiota (GM) dysbiosis modification post-Bariatric surgery (BS) and their link with BSinduced clinical improvement. Noteworthy, we discuss how the major inter-individual variability in terms of GM changes could impact the variable clinical improvements seen in patients. Recent findings: The persisting increase in severe obesity prevalence has led to the subsequent burst in BS number. Indeed, it is to date the best treatment option to induce major and sustainable weight loss and metabolic improvement in these patients. During obesity, the gut microbiota (GM) displays distinctive features such as low microbial gene richness and compositional and functional alterations (termed dysbiosis) which have been associated with low-grade inflammation, increased body weight and fat mass, as well as type-2 diabetes. Interestingly, GM changes post-BS is currently being proposed as one the many mechanism explaining BS beneficial clinical outcomes. Summary: BS enables partial rescue of GM dysbiosis observed during obesity. Some of the GM characteristics modified post-BS (composition in terms of bacteria or functions) are linked to BS beneficial outcomes such as weight loss or metabolic improvements. Nevertheless the changes in GM post-BS display major variability from one patient to the other. Thus further large sample size studies associated with GM transfer studies in animals are still needed to completely decipher the role of GM in the clinical improvements observed post-surgery.

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“…[10] Following bariatric surgery, increased gut microbial diversity and gene richness have been reported. [20][21][22][23][24][25] While the connection between the gut microbiome and sarcoidosis is developing, their relationship may have contributed to the resolution of sarcoidosis following bariatric surgery reported here.…”

Section: Discussionmentioning

confidence: 99%

Improvement of pulmonary sarcoidosis following sleeve gastrectomy

Hassell¹,

Grzeszczak²,

Adams³

et al. 2019

CRIM

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Pulmonary sarcoidosis is unlikely to resolve if it persists for greater than five years. A growing body of literature supports the involvement of the microbiome in sarcoidosis and a role for sex hormones in pulmonary fibrosis. Additionally, obesity is a risk factor for the development of sarcoidosis. Bariatric surgery is an effective treatment for obesity and can lead to microbial and endocrine changes. Here, we report the clinical improvement of longstanding pulmonary sarcoidosis following sleeve gastrectomy.

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Altered gut microbiome after bariatric surgery and its association with metabolic benefits: A systematic review

Cited by 69 publications

References 44 publications

Bariatric Surgery in Obesity: Effects on Gut Microbiota and Micronutrient Status

Bariatric Surgery in Obesity: Effects on Gut Microbiota and Micronutrient Status

Gut Microbiota Dysbiosis in Human Obesity: Impact of Bariatric Surgery

Improvement of pulmonary sarcoidosis following sleeve gastrectomy

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