Altered gut microbiota and its metabolites correlate with plasma cytokines in schizophrenia inpatients with aggression

Deng, Hongxin; He, Lei; Wang, Chong; Zhang, Teng; Guo, Hua; Zhang, Hongwei; Song, Yanning; Chen, Bangtao

doi:10.1186/s12888-022-04255-w

Cited by 21 publications

(8 citation statements)

References 40 publications

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“…Accumulating evidence suggested the engagement of gut microbiota in neuropsychological diseases [37][38][39]. One previous study reported dramatically reduced alpha and beta diversities in AIS patients with an unfavorable outcome [40], while another study exhibited high similarities for both alpha and beta diversities between ischemic stroke patients and healthy individuals [13].…”

Section: Discussionmentioning

confidence: 99%

Association Analysis of Gut Microbiota and Prognosis of Patients with Acute Ischemic Stroke in Basal Ganglia Region

Shi,

Zhao,

Chen

et al. 2023

Microorganisms

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Previous studies have implied the potential impact of gut microbiota on acute ischemic stroke (AIS), but the relationships of gut microbiota with basal ganglia region infarction (BGRI) and the predictive power of gut microbiota in BGRI prognosis is unclear. The aim of this study was to ascertain characteristic taxa of BGRI patients with different functional outcomes and identify their predictive value. Fecal samples of 65 BGRI patients were collected at admission and analyzed with 16s rRNA gene sequencing. Three-month functional outcomes of BGRI were evaluated using modified Rankin Scale (mRS), and patients with mRS score of 0–1 were assigned to good-BGRI group while others were assigned to poor-BGRI group. We further identified characteristic microbiota using linear discriminant analysis effect size, and receiver operating characteristic (ROC) curve was used to determine the predictive value of differential bacteria. According to the mRS score assessed after 3 months of stroke onset, 22 patients were assigned to poor-BGRI group, while 43 patients were assigned to good-BGRI group. Short chain fatty acids-producing bacteria, Romboutsia and Fusicatenibacter, were characteristic microbiota of the good-BGRI group, while pro-inflammatory taxa, Acetanaerobacterium, were characteristic microbiota of the poor-BGRI group. Furthermore, the differential bacteria showed extensive associations with clinical indices. ROC curves, separately plotted based on Romboutsia and Fusicatenibacter, achieved area under the curve values of 0.7193 and 0.6839, respectively. This study identified the efficient discriminative power of characteristic microbiota in BGRI patients with different outcomes and provided novel insights into the associations of gut microbiota with related risk factors.

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Section: Discussionmentioning

confidence: 99%

Association Analysis of Gut Microbiota and Prognosis of Patients with Acute Ischemic Stroke in Basal Ganglia Region

Shi,

Zhao,

Chen

et al. 2023

Microorganisms

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“…SCFAs can provide 70% energy fuel for the intestinal epithelial cells to maintain the integrity of intestinal barrier (11). Published studies showed the leaky gut with intestinal barrier dysfunction causing the increase of pathogen-associated molecular patterns (PAMP) in blood to further deteriorate inflammatory response was attributed to the reduction of fecal SCFAs (11,12). Besides, SCFAs can serve to modulate the leukocytes-induced inflammation in different diseases through their special receptor GPR41, 43 and 109A (13, 14).…”

Section: Introductionmentioning

confidence: 99%

The reduced SCFA-producing gut microbes are involved in the inflammatory activation in Kawasaki disease

et al. 2023

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Kawasaki disease (KD), an acute febrile systemic vasculitis in children, has become the leading cause of acquired heart disease in developed countries. Recently, the altered gut microbiota was found in KD patients during the acute phase. However, little is known about its characteristics and role in the pathogenesis of KD. In our study, an altered gut microbiota composition featured by the reduction in SCFAs-producing bacteria was demonstrated in the KD mouse model. Next, probiotic Clostridium butyricum (C. butyricum) and antibiotic cocktails were respectively employed to modulate gut microbiota. The use of C. butyricum significantly increased the abundance of SCFAs-producing bacteria and attenuated the coronary lesions with reduced inflammatory markers IL-1β and IL-6, but antibiotics depleting gut bacteria oppositely deteriorated the inflammation response. The gut leakage induced by dysbiosis to deteriorate the host’s inflammation was confirmed by the decreased intestinal barrier proteins Claudin-1, Jam-1, Occludin, and ZO-1, and increased plasma D-lactate level in KD mice. Mechanistically, SCFAs, the major beneficial metabolites of gut microbes to maintain the intestinal barrier integrity and inhibit inflammation, was also found decreased, especially butyrate, acetate and propionate, in KD mice by gas chromatography-mass spectrometry (GC-MS). Moreover, the reduced expression of SCFAs transporters, monocarboxylate transporter 1 (MCT-1) and sodium-dependent monocarboxylate transporter 1 (SMCT-1), was also shown in KD mice by western blot and RT-qPCR analyses. As expected, the decrease of fecal SCFAs production and barrier dysfunction were improved by oral C. butyricum treatment but was deteriorated by antibiotics. In vitro, butyrate, not acetate or propionate, increased the expression of phosphatase MKP-1 to dephosphorylate activated JNK, ERK1/2 and p38 MAPK against excessive inflammation in RAW264.7 macrophages. It suggests a new insight into probiotics and their metabolites supplements to treat KD.

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“…Intestinal dysbiosis induced by antibiotic treatment is not commonly used. Still, this type of second insult is worth investigating because there is growing evidence that the mammalian digestive tract microbiome affects host physiology, modulates immunity, development, and nutrient uptake [ 75 , 76 ], and that its disruption affects not only physical but also mental health [ 8 ] due to the dysregulation of the gut-microbiome-brain axis [ 3 , 5 , 11 , [77] , [78] , [79] , [80] , [81] ].…”

Section: Introductionmentioning

confidence: 99%

The influence of antibiotic treatment on the behavior and gut microbiome of adult rats neonatally insulted with lipopolysaccharide

Tejkalová¹,

Jakob²,

Kvasnová³

et al. 2023

Heliyon

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Altered gut microbiota and its metabolites correlate with plasma cytokines in schizophrenia inpatients with aggression

Cited by 21 publications

References 40 publications

Association Analysis of Gut Microbiota and Prognosis of Patients with Acute Ischemic Stroke in Basal Ganglia Region

Association Analysis of Gut Microbiota and Prognosis of Patients with Acute Ischemic Stroke in Basal Ganglia Region

The reduced SCFA-producing gut microbes are involved in the inflammatory activation in Kawasaki disease

The influence of antibiotic treatment on the behavior and gut microbiome of adult rats neonatally insulted with lipopolysaccharide

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