Altered HDL metabolism in metabolic disorders: insights into the therapeutic potential of HDL

Hui, Nicholas; Barter, Philip J.; Rye, Kerry‐Anne

doi:10.1042/cs20190873

Cited by 28 publications

(25 citation statements)

References 128 publications

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“…On the other hand, HDL-C is a well-known protective factor for CVDs and exerts anti-inflammatory capacity in chronic diseases. [34,35] A recent study reported that the level of HDL-C was low in critically ill patients, which was significantly associated with disease severity. [36] Meanwhile, decreased level of HDL-C was found in patients with sepsis, which increased the risk of acute multiple organ failure and mortality in these patients.…”

Section: Discussionmentioning

confidence: 99%

Association Analysis of Hyperlipidemia with the 28-Day All-Cause Mortality of COVID-19 in Hospitalized Patients

Bin,

Jianghua,

Wenxin

et al. 2021

Chinese Medical Sciences Journal

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Objective This study aimed to determine the association of hyperlipidemia with clinical endpoints among hospitalized patients with COVID-19, especially those with pre-existing cardiovascular diseases (CVDs) and diabetes. Methods This multicenter retrospective cohort study included all patients who were hospitalized due to COVID-19 from 21 hospitals in Hubei Province, China between December 31, 2019 and April 21, 2020. Patients who were aged < 18 or ≥ 85, in pregnancy, with acute lethal organ injury (e.g., acute myocardial infarction, severe acute pancreatitis, or acute stroke), hypothyroidism, malignant diseases, severe malnutrition, and those with normal lipid profile undertaking lipid-lowering medicines (e.g., statin, niacin, fenofibrate, or gemfibrozil, ezetimibe) were excluded. Propensity score-matching (PSM) analyses at 1:1 ratio were performed to minimize baseline differences between patient groups of hyperlipidemia and non-hyperlipidemia. PSM analysis with the same strategies were further conducted for the parameters of hyperlipidemia in patients with increased triglyceride (TG), increased low-density lipoprotein cholesterol (LDL-C), and decreased high-density lipoprotein cholesterol (HDL-C). Mixed-effect Cox model analysis were used to investigate the associations between the 28-days all cause deaths of COVID-19 patients with hyperlipidemia and the abnormalities of lipid parameters. The results were verified in male, female patients, and in patients with pre-existing CVDs and type 2 diabetes. Results Of 10,945 inpatients confirmed as COVID-19, there were 9822 inpatients included in the study, comprising 3,513 (35.8%) cases without hyperlipidemia and 6,309 (64.2%) cases with hyperlipidemia. Based on a mixed-effect Cox model after PSM at 1:1 ratio, hyperlipidemia was not associated with increased or decreased 28-day all-cause death (adjusted HR, 1.17 [95% CI, 0.95-1.44], P =0.151). We found that the parameters of hyperlipidemia were not associated

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Section: Discussionmentioning

confidence: 99%

Association Analysis of Hyperlipidemia with the 28-Day All-Cause Mortality of COVID-19 in Hospitalized Patients

Bin,

Jianghua,

Wenxin

et al. 2021

Chinese Medical Sciences Journal

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“…As mentioned above, an increased TGto-CE ratio changes hydrophobic core fluidity and HDL functionality. In particular, these changes in HDL lipid composition affect apolipoprotein quality and quantity, determining a decrease of Apo-AI and Apo-AII levels [66] and altered HDL functionality by decreasing HDL-induced eNOS activation [67], HDL susceptibility to oxidation [18], and their antioxidant activity [68]. Indeed, HDL metabolism is substantially altered in dyslipidemic states.…”

Section: Obesitymentioning

confidence: 99%

HDL Dysfunctionality: Clinical Relevance of Quality Rather Than Quantity

et al. 2021

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High-density lipoproteins (HDLs) represent a class of lipoproteins very heterogeneous in structure, composition, and biological functions, which carry out reverse cholesterol transport, antioxidant, anti-inflammatory, antithrombotic, and vasodilator actions. Despite the evidence suggesting a clear inverse relationship between HDL cholesterol (HDL-c) concentration and the risk for cardiovascular disease, plasma HDL cholesterol levels do not predict the functionality and composition of HDLs. The importance of defining both the amount of cholesterol transported and lipoprotein functionality has recently been highlighted. Indeed, different clinical conditions such as obesity, diabetes mellitus type 2 (T2DM), and cardiovascular disease (CVD) can alter the HDL functionality, converting normal HDLs into dysfunctional ones, undergoing structural changes, and exhibiting proinflammatory, pro-oxidant, prothrombotic, and proapoptotic properties. The aim of the current review is to summarize the actual knowledge concerning the physical–chemical alteration of HDLs related to their functions, which have been found to be relevant in several pathological conditions associated with systemic inflammation and oxidative stress.

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“…HDL-C is a highly effective biomarker, which is considered to be inversely correlated with the risk of cardiovascular diseases and plays a crucial role in predicting adverse results [ 14 – 17 ]. However, as reported in the relevant literature, the classic HDL-C theory defined as the notion that intervention to increase HDL-C concentrations will vastly lessen the occurrence of adverse events is now being questioned [ 1 , 15 , 16 , 18 , 19 ].…”

Section: Introductionmentioning

confidence: 99%

The relationship between high-density lipoprotein cholesterol (HDL-C) and glycosylated hemoglobin in diabetic patients aged 20 or above: a cross-sectional study

Huang

Lei

2021

BMC Endocr Disord

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Aim The incidence rate of diabetes is increasing year by year, seriously threatening human health. As a predictor of glycemic control, glycated hemoglobin is reported to be related to various complications and prognoses of diabetes. Besides, HDL-C dyslipidemia is a component of metabolic syndrome and may be related to various cardiovascular and cerebrovascular diseases. The principal objective of this project was to investigate the relationship between HDL-C and glycosylated hemoglobin in adult diabetic patients. Methods A total of 3171 adult diabetic patients aged 20 years and above were included in the present study from the National Health and Nutrition Examination Survey (NHANES). HDL-C and glycosylated hemoglobin were regarded as independent and dependent variables, respectively. EmpowerStats software and R (version 3.4.3) were used to examine the association between HDL-C and glycosylated hemoglobin. Results HDL-C was inversely associated with glycohemoglobin after adjusting for other covariates (β = − 0.004, 95% CI:− 0.008 to − 0.000, p = 0.044). Race/ethnicity and age were considered the most prominent interactive factors that affect the relationship between HDL and glycosylated hemoglobin by the interaction analysis. A U-shaped association was detected between HDL-C and glycosylated hemoglobin for people of other race/ethnicity or aged 60 and above, which had an inflection point of HDL-C at 60 mg/dL. In contrast, we observed an inverted U-shaped distribution between HDL-C and glycosylated hemoglobin in people under 40 with point of inflection located at 60 mg/dL as well. Conclusions HDL-C in diabetic patients is inversely associated with glycosylated hemoglobin and may be relevant to glycemic control. However, a U-shaped relationship was also observed in a certain kind of people, which implied that, though HDL-C is considered as metabolism and anti-atherogenic property, for diabetics, it is not the higher, the better.

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Altered HDL metabolism in metabolic disorders: insights into the therapeutic potential of HDL

Cited by 28 publications

References 128 publications

Association Analysis of Hyperlipidemia with the 28-Day All-Cause Mortality of COVID-19 in Hospitalized Patients

Association Analysis of Hyperlipidemia with the 28-Day All-Cause Mortality of COVID-19 in Hospitalized Patients

HDL Dysfunctionality: Clinical Relevance of Quality Rather Than Quantity

The relationship between high-density lipoprotein cholesterol (HDL-C) and glycosylated hemoglobin in diabetic patients aged 20 or above: a cross-sectional study

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