Altered immune response in mallard ducklings exposed to lead through maternal transfer in the wild

Vallverdú-Coll, Núria; López-Antia, Ana; Martínez-Haro, Mónica; Ortiz‐Santaliestra, Manuel E.; Mateo, Rafael

doi:10.1016/j.envpol.2015.06.014

Cited by 46 publications

(28 citation statements)

References 43 publications

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“…Cohort sibling nestlings are particularly useful to address this question for a number of reasons. First, they are unlikely to be poisoned by endogenous lead, since they have not lived for long enough to incorporate substantial lead into their bodies (the exception to this is that female birds can deposit lead in their eggs, but such lead is unlikely to be present in blood of the older nestlings we studied here; Blanco et al ., ; Vallverdú‐Coll et al ., ; Golden, Warner & Coffey, ). Second, nestling raptors have almost no access to water and thus drinking poisoned water is an unlikely route of exposure for birds of this age.…”

Section: Introductionmentioning

confidence: 99%

Origins of lead in populations of raptors

Katzner

Stuber

Slabe

et al. 2017

Animal Conservation

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Although poisoning from anthropogenically derived lead threatens wildlife of many species, routes of lead exposure are unclear and rarely empirically tested. We used blood lead concentration and isotope ratio ( 207 Pb/ 206 Pb) data from populations of four species of raptors from across North America to test hypotheses associated with lead exposure via inhalation versus ingestion. Mean variation in blood lead concentration among cohort siblings was non-zero at nests of ferruginous hawks Buteo regalis and osprey Pandion haliaetus (P < 0.001 and P < 0.001), indicating exposure via episodic ingestion. However, within-nest variation in blood lead concentration was not significantly different from zero among cohort siblings at nests of bald eagles Haliaeetus leucocephalus and golden eagles Aquila chrysaetos (P = 0.014 and P = 0.023), consistent with exposure via continuous inhalation. Isotope ratio data corroborated the lead concentration data and within-nest average and variance of blood lead concentrations were positively correlated (r = 0.70 to 0.94), indicating episodic ingestion. This study provides some of the first empirical population-level data to evaluate mechanisms of lead exposure and demonstrates the importance of lead ingestion to avian predators and scavengers.

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Section: Introductionmentioning

confidence: 99%

Origins of lead in populations of raptors

Katzner

Stuber

Slabe

et al. 2017

Animal Conservation

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“…Data indicate that levels of lead (Pb) lower than the current regulations in drinking water may still lead to immune effects (Iavicoli, Carelli, Stanek, Castellino, & Calabrese, 2006). Pb shot is commonly ingested by wildlife, leading to developmental exposure by transfer through the placenta and lethal and immunotoxic effects in the offspring (Vallverdu-Coll, Lopez-Antia, Martinez-Haro, Ortiz-Santaliestra, & Mateo, 2015). Specifically, cellular immune function, as measured by response to the PHA skin test at 2 weeks of age in mallard ducklings, was negatively associated with Pb content in the eggshell.…”

Section: Immunomodulationmentioning

confidence: 99%

Environmental exposures during pregnancy: Mechanistic effects on immunity

Rychlik

Sillé

2019

Birth Defects Research

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In human studies, it is well established that exposures during embryonic and fetal development periods can influence immune health. Coupled with genetic predisposition, these exposures can alter lifetime chronic and infectious disease trajectory, and, ultimately, life expectancy. Fortunately, as research advances, mechanisms governing long‐term effects of prenatal exposures are coming to light and providing the opportunity for intervention and risk reduction. For instance, human association studies have provided a foundation for the association of prenatal exposure to particulate matter with early immunosuppression and later allergic disease in the offspring. Only recently, the mechanisms mediating this response have been revealed and there is much we have yet to discover. Although cellular immune response is understood for many exposure scenarios, molecular pathways are still unidentified. This review will provide commentary and synthesis of the current literature regarding environmental exposures during pregnancy and mechanisms determining immune outcomes. Shared mechanistic features and current gaps in the state of the science are identified and discussed. To such purpose, we address exposures by their immune effect type: immunosuppression, autoimmunity, inflammation and tissue damage, hypersensitivity, and general immunomodulation.

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“…Whilst research focus on wildlife lead impacts has mainly been on acute poisoning leading to death, chronic low-level exposure to lead may be at least as significant demographically. Although much less is known about sub-lethal impacts on wildlife (compared to humans), recent studies indicate a range of potentially significant effects, including, inter alia, sperm motility; immune responses; reduced egg production, hatching rates and duckling survival rates; power-line collision rates; bone mineralization; and movement behaviour (Edens and Garlich 1983;Kelly and Kelly 2005;Gangoso et al 2009;Hunt 2012;Vallverdú-Coll et al 2015, 2016Newth et al 2016;Ecke et al 2017). Such adverse physiological outcomes for individuals have potential to negatively affect populations through demographic impacts on productivity and survival, and thus conflict with the Addis Ababa Principle of avoiding or minimising adverse impacts on ecosystem services, structure and functions as well as other components of ecosystems.…”

Section: Lead Effects On Populations and Biodiversitymentioning

confidence: 99%

Hunting with lead ammunition is not sustainable: European perspectives

Kanstrup

Swift²,

Stroud

et al. 2018

Ambio

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Much evidence demonstrates the adverse effects of lead ammunition on wildlife, their habitats and human health, and confirms that the use of such ammunition has no place within sustainable hunting. We identify the provisions that define sustainable hunting according to European law and international treaties, together with their guidance documents. We accept the substantial evidence for lead's actual and potential effects on wildlife, habitats and health as persuasive and assess how these effects relate to stated provisions for sustainability and hunting. We evaluate how continued use of lead ammunition negatively affects international efforts to halt loss of biodiversity, sustain wildlife populations and conserve their habitats. We highlight the indiscriminate and avoidable health and welfare impacts for large numbers of exposed wild animals as ethically unsustainable. In societal terms, continued use of lead ammunition undermines public perceptions of hunting. Given the existence of acceptable, non-toxic alternatives for lead ammunition, we conclude that hunting with lead ammunition cannot be justified under established principles of public/international policy and is not sustainable. Changing from lead ammunition to non-toxic alternatives will bring significant nature conservation and human health gains, and from the hunter's perspective will enhance societal acceptance of hunting. Change will create opportunities for improved constructive dialogue between hunting stakeholders and others engaged with enhancing biodiversity and nature conservation objectives.

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Altered immune response in mallard ducklings exposed to lead through maternal transfer in the wild

Cited by 46 publications

References 43 publications

Origins of lead in populations of raptors

Origins of lead in populations of raptors

Environmental exposures during pregnancy: Mechanistic effects on immunity

Hunting with lead ammunition is not sustainable: European perspectives

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