Altered Interaction Between Plasminogen Activator Inhibitor Type 1 Activity and Sympathetic Nerve Activity With Aging

Abstract

The study population comprised 16 young healthy subjects (all men: aged between 21 and 37 years, mean age 26.1 years) and 10 aged subjects (9 men, 1 woman; aged between 46 and 71 years, mean age 56.9 years). All aged subjects Circ J 2008; 72: 458 -462 (Received July 11, 2007; revised manuscript received October 16, 2007; accepted November 1, 2007 Background It has been reported that sympathetic nerve activity (SNA) is associated with fibrinolysis, but the interaction between SNA and the fibrinolytic system with aging has not been elucidated in humans. The purpose of this study was to examine the effect of age-related SNA on the activity of plasminogen activator inhibitor type 1 (PAI-1) and tissue plasminogen activator (tPA) using muscle SNA (MSNA). Methods and ResultsThis study included 16 young subjects (mean age 26.1 years) and 10 aged subjects (mean age 56.9 years). Lower body negative pressure (LBNP) was performed at -40 mmHg for 30 min. LBNP significantly increased both tPA and PAI-1 activity (from 5.2±0.5 to 7.3±1.2 IU/ml and from 2.85±0.68 to 4.06± 0.73 U/ml, p<0.01, respectively) in the aged group. In the young group, tPA activity tended to increase, whereas PAI-1 activity was unchanged. There was a correlation between MSNA and PAI-1 activity in the aged group (r=0.47, p<0.01).Conclusions SNA in an aging subject leads to an increase in the activity of PAI-1, which indicates that an altered interaction between SNA and PAI-1 activity contributes to increased cardiovascular events in the elderly population. (Circ J 2008; 72: 458 -462)

Age-Induced Reduction in Mitochondrial Manganese Superoxide Dismutase Activity and Tolerance of Macrophages Against Apoptosis Induced by Oxidized Low Density Lipoprotein

“…[28][29][30][31] Here we showed that aging is associated with the reduction of activity of only one of the various antioxidant enzymes. In addition, we investigated the association of aging with the tolerance of macrophages against oxLDL.…”

V-Shaped Trough in Autonomic Activity Is a Possible Precursor of Life-Threatening Cardiac Events

“…32 Sympathetic activity may promote coagulation (via downregulation of the fibrinolytic system). 33 Schwartz et al demonstrated that autonomic stress could trigger lethal ventricular arrhythmias in dogs with myocardial infarction. 6 These findings indicate that the activation of the sympathetic nervous system may be one of the promoters of those acute events, although not a main cause.…”

Acute Palmar Digital Artery Occlusion Treated Using Endoscopic Ablation of the Thoracic Sympathetic Ganglia: Report of a Case

“…5) Otowa et al demonstrated that hyperactivity of sympathetic nerve system increased PAI-1 activity under hypovolemic state. 6) Considering that PAI-1 is negative regulator for thrombolysis, shutdown of sympathetic activity influences the thrombosis-thrombolysis balance and may shift to thrombolytic state in the occluded artery. Moreover, recent study demonstrated that sympathetic vasoconstriction persisted and restrained muscle blood flow under hypoxia .7) Therefore, immediate ablation of the thoracic sympathetic ganglia may be effective for patients with acute digital arterial occlusion.…”