2010
DOI: 10.1097/meg.0b013e32833b4b03
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Altered intestinal function precedes the appearance of bacterial DNA in serum and ascites in patients with cirrhosis: a pilot study

Abstract: Increased intestinal permeability and abnormal motility were frequent without evidence of bacterial translocation in cirrhosis even without ascites. They are likely to be facilitators for bacterial translocation and thus precede it.

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Cited by 44 publications
(37 citation statements)
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“…Studies using sugar as a differential marker in absorption tests, combining an oligosaccharide and a monosaccharide, such as in lactulose/mannitol (L/M) and saccharose/mannitol, revealed increased intestinal permeability in patients with liver cirrhosis 6,15,5759,8596…”
Section: Analytic Methods To Determine Intestinal Permeabilitymentioning
confidence: 99%
See 3 more Smart Citations
“…Studies using sugar as a differential marker in absorption tests, combining an oligosaccharide and a monosaccharide, such as in lactulose/mannitol (L/M) and saccharose/mannitol, revealed increased intestinal permeability in patients with liver cirrhosis 6,15,5759,8596…”
Section: Analytic Methods To Determine Intestinal Permeabilitymentioning
confidence: 99%
“…Increased intestinal permeability may precede and promote translocation of bacteria,6 endotoxins (such as lipopolysac-charides), and pathogen-associated molecules into the portal venous system and extraintestinal sites.…”
Section: Consequences Of Increased Intestinal Permeabilitymentioning
confidence: 99%
See 2 more Smart Citations
“…There is another study from Latin America [15] that reports delayed OCTT in Brazilian patients with nonalcoholic cirrhosis of Child-Pugh class B. The potential primary role of prolonged small intestinal transit as for BT in patients with cirrhosis can be extrapolated from a pilot trial in the UK showing that it precedes the appearance of bacterial DNA in serum and ascites [16]. …”
Section: Small Intestinal Dysmotilitymentioning
confidence: 99%