Altered Intra- and Inter-Regional Synchronization of Superior Temporal Cortex in Deaf People

Li, Yanyan; Booth, James R.; Peng, Danling; Zang, Yu‐Feng; Li, Junhong; Chen, Yan; Ding, Guiguang

doi:10.1093/cercor/bhs185

Cited by 39 publications

(47 citation statements)

References 81 publications

(104 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Such negative findings may be due to the fact that all UHL patients in current study were postlingual deaf. Previous study revealed that the age of the onset of deafness was critical to cortical plasticity [7,51]. Hence, we inferred that the plastic changes within auditory cortex of acquired UHL patients might be too mild to be significant statistically.…”

Section: Altered Whole-range Nfcs In Uhlmentioning

confidence: 80%

WITHDRAWN: Altered long- and short-range functional connectivity in patients with long-term unilateral hearing loss

Zhang¹,

Mao²,

Feng³

et al. 2017

Oncotarget

View full text Add to dashboard Cite

Functionally cross-modal reorganization in the sensory cortex and changes in cognitive processing areas of the brain have been described in patients with bilateral hearing impairments. However, it remains unclear whether long-term unilateral hearing loss (UHL) would similarly influence the higher-order functional networks in addition to the primary sensory networks. In this study, we collected restingstate fMRI data in 21 right-sided UHL patients caused by acoustic neuromas and 21 healthy controls. Whole-brain functional networks were constructed by measuring the temporal correlations of every pairs of brain voxels. We further computed wholerange, short-range and long-range normalized functional connectivity strength (nFCS) for each voxel in the brain. Nonparametric permutation tests were used to detect between-group differences in these nFCS metrics and to further systematically investigate the relationship between these differences and clinical variables in UHL patients. Compared to healthy controls, the UHL patients showed an increased nFCS mainly in anterior cingulate cortex and dorsal medial prefrontal cortex, and these changes resulted from both short-range and long-range nFCS. The UHL patients also showed decreased whole-range nFCS in visual cortex, resulting from short-range functional changes. Additionally, the UHL patients showed decreased long-range nFCS in the orbital frontal cortex. Together, we observed significantly altered nFCS mainly involving in the default-mode, ventral attention, limbic and visual networks. Our study provides empirical evidence for distance-dependent alteration of functional connectivity in long-term UHL, which may implicate the functionally cross-modal reorganization of the brain involving in primary sensory and higher-order functional networks in long-term UHL.

show abstract

Section: Altered Whole-range Nfcs In Uhlmentioning

confidence: 80%

WITHDRAWN: Altered long- and short-range functional connectivity in patients with long-term unilateral hearing loss

Zhang¹,

Mao²,

Feng³

et al. 2017

Oncotarget

View full text Add to dashboard Cite

show abstract

“…ReHo abnormalities may reflect abnormal local neuronal activity. A lower ReHo may represent local intraregional reduced neuron activity or regular disorder [ 7 ], which can strongly affect the brain neurons involved in information processing, as demonstrated in acquired deafness [ 10 ] and severe depression [ 11 ]. Enhanced ReHo reflects neuron activity in the region of the brain by increased time synchronization and strengthened brain function [ 12 ].…”

Section: Discussionmentioning

confidence: 99%

Alteration of Regional Homogeneity within the Sensorimotor Network after Spinal Cord Decompression in Cervical Spondylotic Myelopathy: A Resting-State fMRI Study

Tan

Zhou

et al. 2015

BioMed Research International

View full text Add to dashboard Cite

There is a lack of longitudinal research to evaluate the function of neurons' adaptive changes within the sensorimotor network (SMN) following recovery after cervical cord decompression. Regional homogeneity (ReHo) may provide information that is critical to fully understand CSM-related functional neural synchrony alterations. The purpose of this study was to assess the ReHo alterations of resting state-functional MRI (rs-fMRI) within pre- and postdecompression CSM and healthy controls (HC) and its correlations with clinical indices. Predecompression CSM demonstrated a significantly lower ReHo in the left primary sensory cortex and primary motor cortex (PostG/PreG) but enhanced ReHo in the right superior parietal lobule (SPL) compared with HC. In comparison with predecompression CSM, the postdecompression CSM showed increased ReHo in the left PostG/PreG but significantly lower ReHo in the right SPL compared with HC patients. Abnormal ReHo regions in pre- or postdecompression CSM showed no significant correlation with the Japanese Orthopaedic Association (JOA) scores, Neck Disability Index (NDI) scores, and disease duration (P > 0.05). This result demonstrated disrupted regional homogeneity within SMN in CSM. This adaptive change in the brain may favor the preservation of sensorimotor networks before and after cervical cord decompression and clinical symptoms independent of ReHo within SMN.

show abstract

“…Greater language competence was associated with higher integration within nodes of the frontotemporal network. Better language function measured by story writing and a standardized test of Mandarin was associated with higher connectivity within the temporal nodes of the frontotemporal network (e.g., ReHo within right superior temporal gyrus [STG], and inter-and intrahemispheric connectivity of the right STG) in congenitally and acquired deaf individuals (Li et al, 2012b). Higher verbal IQ scores were associated with higher connectivity within the IFG in patients with epilepsy with left-sided, but not right-sided, seizure focus (Pravatà et al, 2011).…”

Section: Languagementioning

confidence: 99%

Phenotypic Variability in Resting-State Functional Connectivity: Current Status

2013

View full text Add to dashboard Cite

We reviewed the extant literature with the goal of assessing the extent to which resting-state functional connectivity is associated with phenotypic variability in healthy and disordered populations. A large corpus of work has accumulated to date (125 studies), supporting the association between intrinsic functional connectivity and individual differences in a wide range of domains-not only in cognitive, perceptual, motoric, and linguistic performance, but also in behavioral traits (e.g., impulsiveness, risky decision making, personality, and empathy) and states (e.g., anxiety and psychiatric symptoms) that are distinguished by cognitive and affective functioning, and in neurological conditions with cognitive and motor sequelae. Further, intrinsic functional connectivity is sensitive to remote (e.g., early-life stress) and enduring (e.g., duration of symptoms) life experience, and it exhibits plasticity in response to recent experience (e.g., learning and adaptation) and pharmacological treatment. The most pervasive associations were observed with the default network; associations were also widespread between the cingulo-opercular network and both cognitive and affective behaviors, while the frontoparietal network was associated primarily with cognitive functions. Associations of somatomotor, frontotemporal, auditory, and amygdala networks were relatively restricted to the behaviors linked to their respective putative functions. Surprisingly, visual network associations went beyond visual function to include a variety of behavioral traits distinguished by affective function. Together, the reviewed evidence sets the stage for testing causal hypothesis about the functional role of intrinsic connectivity and augments its potential as a biomarker for healthy and disordered brain function.

show abstract

Altered Intra- and Inter-Regional Synchronization of Superior Temporal Cortex in Deaf People

Cited by 39 publications

References 81 publications

WITHDRAWN: Altered long- and short-range functional connectivity in patients with long-term unilateral hearing loss

WITHDRAWN: Altered long- and short-range functional connectivity in patients with long-term unilateral hearing loss

Alteration of Regional Homogeneity within the Sensorimotor Network after Spinal Cord Decompression in Cervical Spondylotic Myelopathy: A Resting-State fMRI Study

Phenotypic Variability in Resting-State Functional Connectivity: Current Status

Contact Info

Product

Resources

About