Altered large-scale internetwork functional connectivity in patients with vestibular migraine and migraine without aura

Zhang, Bing; Wu, Dongpeng; Guo, Yang; Yan, Wenjing; Liu, Xuejun; Yang, Zhen; Deng, Jin; Wang, Haiping

doi:10.1016/j.neulet.2023.137123

Cited by 8 publications

(7 citation statements)

References 32 publications

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“…High and low DC values in specific brain areas correspond to increased and decreased global connectivity, respectively (Zuo et al, 2012). In contrast to previous resting-state fMRI investigations that concentrated on regional functional measurements, i.e., ReHo (Li et al, 2023), ALFF (Liu et al, 2020;Li et al, 2023), ICA (Li et al, 2022;Chen et al, 2023), seed-based FC (Wang et al, 2023), and large-scale brain network analysis (Zhang et al, 2023), the index of voxel-wise DC can highlight the influence and significance of a given network at the voxel level and indicate the hub features of the functional brain network. This method has been extensively applied to survey DC abnormalities in relation to conditions such as trigeminal neuralgia (Liu et al, 2022;Ge et al, 2023), migraine (Zhang et al, 2017;Lee et al, 2019), and neuropathic pain (Zhang et al, 2022).…”

Section: Introductionmentioning

confidence: 95%

Brain functional connectivity patterns associated with symptoms of vestibular migraine

Zhe,

Zhang,

Tang

et al. 2023

Front. Neurosci.

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BackgroundSeveral functional magnetic resonance imaging (fMRI) investigations of patients with vestibular migraine (VM) have revealed abnormal functionality in different networks, indicating that VM is related to alterations in brain function. We sought to investigate the resting-state functional connectivity (FC) patterns during the interictal period in VM by combining data-driven voxel-wise degree centrality (DC) calculations and seed-based FC analyses, and thereby determine the associations between cerebral function and clinical symptoms.MethodsThirty-eight patients with VM and 33 matched normal controls were recruited. DC was calculated and compared between the groups, and the FC of locations showing DC alterations was further tested using a seed-based technique. The participants’ clinical indicators were correlated with the DC and FC values of the brain areas.ResultsIn contrast to the control group, the VM group showed considerably lower DC values in the bilateral medial prefrontal cortex (mPFC) and significantly higher DC values in the right occipital lobe. In the seed-based FC analyses, patients with VM demonstrated fewer connections of the bilateral mPFC with the bilateral posterior cingulate cortex, right parahippocampus, right cerebellar posterior lobe, bilateral cuneus, and left precuneus. In addition, clinical data from patients, such as pain intensity, episode frequency, and the Dizziness Handicap Inventory score, were negatively related to these FC and DC impairments.ConclusionOur findings showed changes in the default mode network and visual cortex in patients with VM, providing further insights into the complexity of the mechanisms underlying VM.

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Section: Introductionmentioning

confidence: 95%

Brain functional connectivity patterns associated with symptoms of vestibular migraine

Zhe,

Zhang,

Tang

et al. 2023

Front. Neurosci.

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“…Based on blood oxygen level-dependent (BOLD), the resting-state fMRI reflected inherent abnormality and revealed more fundamental brain functional alterations in patients with neurological and psychotic disorders [ 71 – 73 ]. Using resting-state fMRI technique, previous studies have reported the intrinsic abnormalities in brain functional activity in patients with VM, which involve many brain regions and networks [ 10 , 18 – 27 ]. The FC analyses in the current study revealed significant increased FC between right PreCG and left PostCG in patients with VM, indicating enhanced functional interactions between motor and somatosensory networks (namely, within sensorimotor network).…”

Section: Discussionmentioning

confidence: 99%

“…Thus, resting-state fMRI is much easier to carry out and has been increasingly used in recent VM studies. Previous resting-state fMRI studies on VM mainly adopted analytic methods of amplitude of low-frequency fluctuation (ALFF), fractional ALFF (fALFF), regional homogeneity (ReHo), functional connectivity (FC), data-driven voxel-wise degree centrality (DC), independent component analysis (ICA), functional network connectivity (FNC), dynamic ALFF and ReHo, and dynamic FNC, etc [18][19][20][21][22][23][24][25][26][27]. .…”

Section: Introductionmentioning

confidence: 99%

“…It is apparent that neuroimaging studies using techniques of high-resolution T1WI, 18 F-fluorodeoxy glucose PET, task-state fMRI and resting-state fMRI to explore brain alterations in patients with VM have shown that multiple brain regions and networks involved in the pathological mechanism of VM, both structurally and functionally [9][10][11][12][13][14][15][16][17][18][19][20][21][22][23][24][25][26][27]. Undeniably, these neuroimaging studies extensively contributed to elucidate the complex mechanisms underpinning the pathophysiology of VM.…”

Section: Introductionmentioning

confidence: 99%

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Aberrant cerebral blood flow and functional connectivity in patients with vestibular migraine: a resting-state ASL and fMRI study

Chen,

Liu,

Lin

et al. 2024

J Headache Pain

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Background Prior neuroimaging studies on vestibular migraine (VM) have extensively certified the functional and structural alterations in multiple brain regions and networks. However, few studies have assessed the cerebral blood flow (CBF) in VM patients using arterial spin labeling (ASL). The present study aimed to investigate CBF and functional connectivity (FC) alterations in VM patients during interictal periods. Methods We evaluated 52 VM patients and 46 healthy controls (HC) who received resting-state pseudo-continuous ASL and functional magnetic resonance imaging (fMRI) scanning. Comparisons of voxel-based CBF and seed-based FC were performed between the two groups. Brain regions showed significant group differences in CBF analyses were chosen as seeds in FC analyses. Additionally, the associations between abnormal imaging results and clinical features were explored. Results Compared with HC, VM patients showed higher normalized CBF in the right precentral gyrus (PreCG), left postcentral gyrus (PostCG), left superior frontal gyrus and bilateral insular (p < 0.05, FDR corrected). Furthermore, VM patients exhibited increased FC between the right PreCG and areas of the left PostCG, left cuneus and right lingual gyrus (p < 0.05, FDR corrected). In addition, we observed decreased FC between the left insular and regions of the left thalamus and right anterior cingulate cortex, as well as increased FC between the left insular and right fusiform gyrus in VM patients (p < 0.05, FDR corrected). Moreover, these variations in brain perfusion and FC were significantly correlated with multiple clinical features including frequency of migraine symptoms, frequency of vestibular symptoms and disease duration of VM (all p < 0.05). Conclusions Patients with VM during interictal period showed hyperperfusion and abnormal resting-state FC in brain regions potentially contributed to disrupted multi-sensory and autonomic processing, as well as impaired ocular motor control, pain modulation and emotional regulation. Our study provided novel insights into the complex neuropathology of VM from a CBF perspective.

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“…By examining FC using a seed-based approach, Chen et al showed abnormal functional coupling with the thalamus and parietal operculum cortex in VM patients relative to HC [11,12]. Furthermore, atypical FC within or between resting-state networks, including the visual, auditory, sensorimotor network, as well as salience, executive and default mode network has been observed in resting-state fMRI studies on VM [13][14][15].…”

Section: Introductionmentioning

confidence: 99%

Dynamics and concordance alterations of regional brain function indices in vestibular migraine: a restingstate fMRI study

Xiong,

Dai,

Chen

et al. 2023

Preprint

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Background Prior MRI studies on vestibular migraine (VM) have revealed abnormalities in static regional intrinsic brain activity (iBA) and dynamic functional connectivity between brain regions or networks. However, the temporal variation and concordance of regional iBA measures remain to be explored. Methods 57 VM patients during the interictal period were compared to 88 healthy controls (HC) in this resting-state functional magnetic resonance imaging (fMRI) study. The dynamics and concordance of regional iBA indices, including amplitude of low-frequency fluctuations (ALFF) and regional homogeneity (ReHo), were examined by utilizing sliding time-window analysis. Partial correlation analyses were performed between clinical parameters and resting-state fMRI indices in brain areas showing significant group differences. Results The VM group showed increased ALFF and ReHo dynamics, as well as increased temporal concordance between ALFF and ReHo in the bilateral paracentral lobule and supplementary motor area relative to the HC group. We also found decreased ReHo dynamics in the right temporal pole, and decreased ALFF dynamics in the right cerebellum posterior lobe, bilateral angular gyrus and middle occipital gyrus (MOG) in the VM group compared with the HC group. Moreover, a positive correlation was observed between ALFF dynamics in the left MOG and vertigo disease duration across all VM patients. Conclusion Temporal dynamics and concordance of regional iBA indices were altered in the motor cortex, cerebellum, occipital and temporoparietal cortex, which may contribute to disrupted multisensory processing and vestibular control in patients with VM. ALFF dynamics in the left MOG may be useful biomarker for evaluating vertigo burden in this disorder.

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Altered large-scale internetwork functional connectivity in patients with vestibular migraine and migraine without aura

Cited by 8 publications

References 32 publications

Brain functional connectivity patterns associated with symptoms of vestibular migraine

Brain functional connectivity patterns associated with symptoms of vestibular migraine

Aberrant cerebral blood flow and functional connectivity in patients with vestibular migraine: a resting-state ASL and fMRI study

Dynamics and concordance alterations of regional brain function indices in vestibular migraine: a restingstate fMRI study

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