Altered levels of brain neurotransmitter from new born rabbits with intrauterine restriction

Hernández‐Andrade, Edgar; Cortés-Camberos, A.J.; Díaz, N.F.; Flores‐Herrera, Héctor; García‐López, Guadalupe; González-Jiménez, Marco Antonio; Santamarı́a, Abel; Molina‐Hernández, Anayansí

doi:10.1016/j.neulet.2014.09.051

Cited by 15 publications

(19 citation statements)

References 39 publications

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“…Published by Elsevier Ltd. All rights reserved. data, excepting two recent studies in newborn rabbits (Hernandez-Andrade et al, 2015) and piglets . However, there is no information, to the best of our knowledge, linking occurrence of IUGR and changes in the neurotransmitters profile during prenatal stages.…”

Section: Introductionmentioning

confidence: 78%

“…However, there are observational evidences addressing that IUGR‐offspring, in spite of compensatory brain‐sparing, have short‐ and long‐term deficiencies at the limbic system, causing cognitive, emotional and interactive impairments (Geva et al, 2012; Miller et al, 2016). These alterations have been hypothesized to be mainly related to changes in the profile of neurotransmitters (catecholamines and indoleamines) at the limbic system (Bauer et al, 2003; Palmiter, 2007; Berumen et al, 2012), but there is a scarcity of data, excepting two recent studies in newborn rabbits (Hernandez‐Andrade et al, 2015) and piglets (Vazquez‐Gomez et al, 2016). However, there is no information, to the best of our knowledge, linking occurrence of IUGR and changes in the neurotransmitters profile during prenatal stages.…”

Section: Introductionmentioning

confidence: 99%

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Fetal growth‐retardation and brain‐sparing by malnutrition are associated to changes in neurotransmitters profile

García-Contreras¹,

Valent²,

Vázquez-Gómez³

et al. 2017

Intl J of Devlp Neuroscience

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The present study assesses possible changes in the levels of different neurotransmitters (catecholamines and indoleamines) in fetuses affected by nutrient shortage. Hence, we determined the concentration of catecholamines and indoleamines at the hypothalamus of 56 swine fetuses obtained at both 70 and 90days of pregnancy (n=33 and 23 fetuses, respectively). The degree of fetal development and the fetal sex affected the neurotransmitters profile at both stages. At Day 70, there were found higher mean concentrations of l-DOPA in both female and male fetuses with severe IUGR; male fetuses with severe IUGR also showed higher concentrations of TRP than normal male littermates. At Day 90 of pregnancy, the differences between sexes were more evident. There were no significant effects from either severe IUGR on the neurotransmitter profile in male fetuses. However, in the females, a lower body-weight was related to lower concentrations of l-DOPA and TRP and those female fetuses affected by severe IUGR evidenced lower HVA concentration. In conclusion, the fetal synthesis and use of neurotransmitters increase with time of pregnancy but, in case of IUGR, both catecholamines and indoleamines pathways are affected by sex-related effects.

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Section: Introductionmentioning

confidence: 78%

Section: Introductionmentioning

confidence: 99%

Fetal growth‐retardation and brain‐sparing by malnutrition are associated to changes in neurotransmitters profile

García-Contreras¹,

Valent²,

Vázquez-Gómez³

et al. 2017

Intl J of Devlp Neuroscience

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show abstract

“…Indoleamine neurotransmitters are mainly involved in perception of food availability and management of social interactions and behavior for food acquisition (Berumen et al, 2012). Previous studies in rodents have reported significant increases of 5-HT and its metabolite 5-HIAA in individuals affected by IUGR (Chanez et al, 1981;Jensen et al, 1996;Manjarréz et al, 1996Manjarréz et al, , 1988; however, a recent study in rabbits evidenced a lack of significant differences between control and IUGR individuals (Hernández-Andrade et al, 2015). We can hypothesize that divergences among studies may be related to species-specific effects, to differences in the brain structures where neurotransmitters are analyzed, to different age of the studied individuals or even to different methods to get the occurrence of IUGR.…”

Section: Discussionmentioning

confidence: 99%

“…Hence, there is a strong necessity for research in the area for the future development of diagnostic, preventive and therapeutic strategies to diminish the incidence and consequences of IUGR. However, there is a paucity of studies, except a recent experiment in rabbits (Hernández-Andrade et al, 2015), evaluating the profiles of different excitatory and inhibitory neurotransmitters at the limbic system, which play a major role in autonomic functions.…”

Section: Introductionmentioning

confidence: 99%

Sex and intrauterine growth restriction modify brain neurotransmitters profile of newborn piglets

Vázquez-Gómez¹,

Valent²,

García-Contreras³

et al. 2016

Intl J of Devlp Neuroscience

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The current study aimed to determine, using a swine model of intrauterine growth restriction (IUGR), whether short- and long-term neurological deficiencies and interactive dysfunctions of Low Birth-Weight (LBW) offspring might be related to altered pattern of neurotransmitters. Hence, we compared the quantities of different neurotransmitters (catecholamines and indoleamines), which were determined by HPLC, at brain structures related to the limbic system (hippocampus and amygdala) in 14 LBW and 10 Normal Body-Weight (NBW) newborn piglets. The results showed, firstly, significant effects of sex on the NBW newborns, with females having higher dopamine (DA) concentrations than males. The IUGR processes affected DA metabolism, with LBW piglets having lower concentrations of noradrenaline at the hippocampus and higher concentrations of the DA metabolites, homovanillic acid (HVA), at both the hippocampus and the amygdala than NBW neonates. The effects of IUGR were modulated by sex; there were no significant differences between LBW and NBW females, but LBW males had higher HVA concentration at the amygdala and higher concentration of 5-hydroxyindoleacetic acid, the serotonin metabolite, at the hippocampus than NBW males. In conclusion, the present study shows that IUGR is mainly related to changes, modulated by sex, in the concentrations of catecholamine neurotransmitters, which are related to adaptation to physical activity and to essential cognitive functions such as learning, memory, reward-motivated behavior and stress.

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“…Of particular interest in relation to migraine, animal studies have shown alterations in neurotransmitter levels in various parts of the brain, with increased excitatory glutaminergic activity, and decreased inhibitory GABA-ergic activity [34], in addition to increased levels of dopamine, noradrenalin and serotonin [34–36]. Several lines of evidence suggest an imbalance of synaptic excitation-inhibition in migraine, resulting in a hyperexcitable state.…”

Section: Discussionmentioning

confidence: 99%

The effect of foetal growth restriction on the development of migraine and tension-type headache in adulthood. The HUNT Study

et al. 2017

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BackgroundThere is little knowledge about how factors early in life affect the development of migraine and tension-type headache. We aimed to examine whether growth restriction in utero is associated with development of migraine and frequent tension-type headache in adults.MethodsThe population-based Nord-Trøndelag Health Study (HUNT 3) contained a validated headache questionnaire, which differentiated between migraine and tension-type headache. These data were linked to information on weight and gestational age at birth from the Norwegian Medical Birth Registry. In total 4557 females and 2789 males, aged 19–41 years, were included in this registry-based study. Participants were categorized as appropriate for gestational age (AGA, 10th-90th percentile), small for gestational age (SGA, 3rd-10th percentile) or very small for gestational age (VSGA, < 3rd percentile). Logistic regression was used to calculate odds ratios (OR) with 95% confidence intervals (CI) for migraine and tension-type headache, with exposure being growth restriction at birth.ResultsThe effect of growth restriction on migraine was modified by sex, with a significant association in males (p<0.001), but not in females (p = 0.20). In particular, males born VSGA were at increased risk of developing migraine (OR 2.73, 95% CI 1.63–4.58, p<0.001), with an intermediate risk among those born SGA (OR 1.50, 95% CI 0.96–2.35, p = 0.08) compared to those born AGA. There was no significant association between growth restriction and frequent TTH (p = 0.051).ConclusionGrowth restriction was associated with increased risk of migraine in adulthood among males, but not among females. This suggests that migraine might, in part, be influenced by early life events, and that males seem to be particularly vulnerable.

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Altered levels of brain neurotransmitter from new born rabbits with intrauterine restriction

Cited by 15 publications

References 39 publications

Fetal growth‐retardation and brain‐sparing by malnutrition are associated to changes in neurotransmitters profile

Fetal growth‐retardation and brain‐sparing by malnutrition are associated to changes in neurotransmitters profile

Sex and intrauterine growth restriction modify brain neurotransmitters profile of newborn piglets

The effect of foetal growth restriction on the development of migraine and tension-type headache in adulthood. The HUNT Study

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