Altered Levels of Sphingosine and Sphinganine in Psoriatic Epidermis

Moon, Sung-Hyuk; Kim, Ju‐Young; Song, Eun-Hwa; Shin, Min Kyung; Cho, Yunhi; Kim, Nack-In

doi:10.5021/ad.2013.25.3.321

Cited by 32 publications

(28 citation statements)

References 26 publications

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“…Even though there are no data available on increased ceramidase activity in psoriatic patients, Moon et al [35] described a highly significant positive correlation between the % change of ceramidase activity in the lesional skin of psoriatic patients and PASI score.…”

Section: Discussionmentioning

confidence: 99%

Increase in circulating sphingosine-1-phosphate and decrease in ceramide levels in psoriatic patients

et al. 2016

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Psoriasis is characterized by hyperproliferation, deregulated differentiation and impaired apoptosis of keratinocytes. Mechanisms of lipid profile disturbances and metabolic syndrome in the psoriatic patients are still not fully understood. Sphingolipids, namely ceramides (CER) and sphingosine-1-phosphate (S1P) are signal molecules which can regulate cell growth, apoptosis and immune reactions. The aim of the study was to evaluate circulating CER and S1P levels in plaque-type psoriasis and their associations with the disease activity, inflammatory or metabolic markers and the presence of psoriatic comorbidities. Eighty-five patients with exacerbated plaque-type psoriasis and thirty-two healthy controls were enrolled. Serum CER and S1P concentrations before the treatment were examined. General patient characteristics included: PASI (Psoriasis Area and Severity Index), BMI (Body Mass Index), inflammatory and biochemical markers, lipid profile and presence of psoriatic comorbidities. Total serum concentration of CER was significantly decreased (p = 0.02) and concomitantly S1P levels significantly increased (p = 0.002) in psoriatic patients compared to the healthy control group. Among patients with psoriasis no significant correlations with the disease activity and inflammation markers were observed and only patients with psoriatic arthritis had significantly higher CER total concentration. Serum sphingolipid disturbances in psoriatic patients were observed. Decreased total CER and increased S1P serum levels may reflect their epidermal altered composition and metabolism. Patients with psoriatic arthritis have higher CER levels than psoriasis with skin involvement only. It might provide additional predictive value for psoriatic arthritis and may convey higher risk of metabolic and cardiovascular disease development in this group of patients.

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Section: Discussionmentioning

confidence: 99%

Increase in circulating sphingosine-1-phosphate and decrease in ceramide levels in psoriatic patients

et al. 2016

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“…Z kolei S1P jest antagonistą ceramidów, reguluje odpowiedź immunologiczną i angiogenezę [21,22]. Wykazano zmniejszoną ilość CER w skórze zmienionej łuszczycowo w porównaniu z niezajętą chorobą oraz zwiększoną ilość sfingozyny, prekursora S1P [23,24]. U myszy pozbawionych enzymu palmitoilotransferazy serynowej (serine palmitoyltransferase -SPT), biorącego udział w syntezie CER, wystąpiły zmiany łuszczy-copodobne potwierdzone histopatologicznie [25].…”

Section: Serum Lipids Cholesterols Triglycerides and Apolipoproteinsunclassified

“…S1P is an antagonist of ceramides, regulating immune response and angiogenesis [21,22]. A reduced amount of CER in psoriatic skin, compared to unaffected skin, and an increased amount of sphingosine, a precursor of S1P, have been demonstrated [23,24]. Mice deficient in serine palmitoyltransferase (SPT) enzyme involved in CER synthesis, have been found to develop histopathologically verified psoriasis-like lesions [25].…”

Section: Lipidy W Naskórkumentioning

confidence: 99%

The role of lipids in psoriasis

Baran¹,

Kiluk²,

Myśliwiec³

et al. 2017

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Psoriasis, affecting 2-4% of the world's population, is a chronic recurrent inflammatory skin disease. Its multifactorial aetiopathogenesis consists of, for example, abnormal epidermal proliferation, immune disturbances, and genetic, psychosomatic, environmental and hormonal factors. Psoriasis is also considered to be a systemic disorder closely associated with cardiovascular diseases, atherosclerosis, diabetes mellitus, obesity or metabolic syndrome. Lipids have a variety of biological functions. They participate not only in energy storage and expenditure or the formation of cell membranes, but also in inflammatory and metabolic signalling pathways. Disturbances in their homeostasis lead to the development of immunometabolic disorders, including psoriasis. Based on the available literature, this article presents selected molecular and clinical aspects involved in the multidirectional effect of lipids on psoriasis.streszczenie Łuszczyca, która występuje u 2-4% populacji na świecie, jest przewlekłą i nawrotową chorobą zapalną skóry. Na jej wieloczynnikową etiopatogenezę składają się m.in. nieprawidłowa proliferacja naskórka, zaburzenia immunologiczne, czynniki genetyczne, psychosomatyczne, środowiskowe i hormonalne. Łuszczyca jest również uznawana za schorzenie ogólnoustrojowe, związane z chorobami układu sercowo--naczyniowego, miażdżycą, cukrzycą, otyłością i zespołem metabolicznym. Lipidy pełnią wiele biologicznych funkcji, biorą udział nie tylko w magazynowaniu i wydatkowaniu energii, tworzeniu błon komórko-wych, lecz także w zapalnych i metabolicznych szlakach sygnałowych. Zaburzenia ich homeostazy powodują rozwój schorzeń immunometabolicznych, w tym łuszczycy. W niniejszej pracy przedstawiono na podstawie dostępnego piśmiennictwa wybrane aspekty molekularne i kliniczne wielokierunkowego wpływu lipidów na łuszczycę.

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“…Not only the ceramide profiles but also the levels of sphingoid bases were changed in the psoriatic epidermis. Sung and colleagues reported that levels of sphingosine and sphinganine were increased in the psoriatic epidermis and increased expression of ceramidase was positively correlated with the clinical severity of psoriasis[9]. These studies suggest that the alteration of SC lipids could, at least partially, be linked to the decreased skin barrier function in the skin of psoriasis patients.…”

Section: Lipidomics In Skin Diseasesmentioning

confidence: 99%

Lipidomic analysis of epidermal lipids: a tool to predict progression of inflammatory skin disease in humans

Ganguli‐Indra

Indra

2016

Expert Review of Proteomics

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Introduction Lipidomics is the large-scale profiling and characterization of lipid species in a biological system using mass spectrometry. The skin barrier is mainly comprised of corneocytes and a lipid-enriched extracellular matrix. The major skin lipids are ceramides, cholesterol and free fatty acids. Lipid compositions are altered in inflammatory skin disorders with disrupted skin barrier such as atopic dermatitis (AD). Areas covered Here we discuss some of the recent applications of lipidomics in human skin biology and in inflammatory skin diseases such as AD, psoriasis and Netherton syndrome. We also review applications of lipidomics in human skin equivalent and in pre-clinical animal models of skin diseases to gain insight into the pathogenesis of the skin disease. Expert commentary Skin lipidomics analysis could be a fast, reliable and noninvasive tool to characterize the skin lipid profile and to monitor the progression of inflammatory skin diseases such as AD.

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Altered Levels of Sphingosine and Sphinganine in Psoriatic Epidermis

Cited by 32 publications

References 26 publications

Increase in circulating sphingosine-1-phosphate and decrease in ceramide levels in psoriatic patients

Increase in circulating sphingosine-1-phosphate and decrease in ceramide levels in psoriatic patients

The role of lipids in psoriasis

Lipidomic analysis of epidermal lipids: a tool to predict progression of inflammatory skin disease in humans

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