Altered long- and short-range functional connectivity in the patients with end-stage renal disease: a resting-state functional MRI study

Zhang, Xiaodong; Wen, Jie; Xu, Qiang; Qi, Rongfeng; Chen, Huijuan; Kong, Xiang; Wei, Lu-De; Xu, Min; Zhang, Long Jiang; Lu, Guang Ming

doi:10.1007/s11011-015-9683-z

Cited by 19 publications

(9 citation statements)

References 44 publications

(66 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Therefore, the findings should be interpreted with caution and further study is needed to collect data from patients with chronic kidney disease (stage 4–5) without hemodialysis to be able to explore whether and how hemodialysis itself can affect the intrinsic functional connectivity. Fifth, previous revious studies indicated that abnormal long- and short-range functional connectivity density in physical disease [58,59], in the future study, we are planning to investigate the alternation of brain structural and functional hub in ESRD patients by recruiting a large sample. Lastly, due to the cross-sectional design of our study, we cannot address how the vulnerability of the patients progresses to symptom burden and if there is any possible link between the vulnerability and their risk of cognitive impairment.…”

Section: Discussionmentioning

confidence: 99%

Altered functional connectivity density in the brains of hemodialysis end-stage renal disease patients: An in vivo resting-state functional MRI study

Shi¹,

Tong²,

Zhang

et al. 2019

PLoS ONE

View full text Add to dashboard Cite

BackgroundEnd-stage renal disease (ESRD) patients usually suffer from a high prevalence of central nervous system abnormalities, including cognitive impairment and emotional disorders, which severely influence their quality of life. There have been many neuroimaging research developments in ESRD patients with brain function abnormalities; however, the dysfunction of the salience network (SN) of them has received little attention. The purpose of this study was to investigate the changes of global functional connectivity density (gFCD) in brains of ESRD patients undergoing hemodialysis using resting-state functional magnetic resonance imaging (re-fMRI).Methodsre-fMRI data were collected from 30 ESRD patients undergoing hemodialysis (14 men, 38.33±7.44 years old) and 30 matched healthy controls (13 men, 39.17±5.7 years old). Neuropsychological tests including the Montreal Cognitive Assessment (MoCA) and Beck Depression Inventory (BDI) were used to evaluate the neurocognitive and psychiatric conditions of the subjects. Blood biochemistry tests, including hemoglobin level, serum albumin level, blood urea level, serum phosphate, serum calcium, and parathyroid hormone level, and dialysis-related indicators, including blood pressure fluctuations in dialysis, single-pool Kt/V(spKt/V), and ultrafiltration volume of dialysis were obtained from the ESRD patients. A two-sample t-test was used to examine the group differences in gFCD between ESRD patients and healthy controls after controlling for age, gender and education.ResultsCompared with healthy controls, ESRD patients exhibited a significantly increased gFCD in the salience network, including the bilateral insula, and dorsal anterior cingulated cortex (dACC), and there was no significant correlation between gFCD and the structural mean grey matter volume in patients for every cluster in the brain regions showing significant different gFCD between the two groups. Furthermore, there were significant negative correlations between the degree of connectivity in the right insula and spKt/V.ConclusionOur findings revealed abnormal intrinsic dysconnectivity pattern of salience network-related regions in ESRD patients from the whole brain network perspective. The negative correlation between the right insula and spKt/V suggested that increased fractional removal of urea may reduce the pathological activity in the insula.

show abstract

Section: Discussionmentioning

confidence: 99%

Altered functional connectivity density in the brains of hemodialysis end-stage renal disease patients: An in vivo resting-state functional MRI study

Shi¹,

Tong²,

Zhang

et al. 2019

PLoS ONE

View full text Add to dashboard Cite

show abstract

“…Functional MRI showed reduced regional homogeneity in bilateral frontal, parietal and temporal regions of the brain in patients with end-stage kidney disease, which correlated with cognitive function tests. These changes were more prominent in haemodialysis patients compared to non-dialysed end-stage kidney disease patients and correlated with CI, pre-dialysis serum creatinine and duration of haemodialysis [45-46]. Another functional MRI study of the whole brain in haemodialysis patients showed bilateral activation of hippocampus suggesting activation of memory-relevant brain areas during dialysis [47].…”

Section: Discussionmentioning

confidence: 99%

Cognitive Function Declines Significantly during Haemodialysis in a Majority of Patients: A Call for Further Research

et al. 2018

View full text Add to dashboard Cite

Introduction: Cognitive impairment (CI) is very common condition that occurs in haemodialysis patients and it is associated with reduced functional capacity and mortality. We assessed the change in cognitive function during haemodialysis and associated risk factors. Methods: All patients ≥50 years, on haemodialysis for ≥3 months, no dementia from 2 dialysis centres were selected. Cognition was assessed before and after a haemodialysis session using parallel versions of the Montreal Cognitive Assessment (MOCA) tool. Multiple regression was used to examine potential confounders. Results: Eight-two patients completed both tests – median age 73 (52–91) years, 59% male, dialysis vintage 41 (3–88) months. Sixty-two (76%) had CI at baseline. Cognition declined over dialysis (MOCA 21 ± 4.8 to 19.1 ± 4.1, p < 0.001) and domains affected were attention, language, abstraction and delayed recall. Age and dialysis vintage were independently associated with decline. Conclusion: Cognitive function declines over a haemodialysis session and this has significant clinical implications over health literacy, self-management and tasks like driving. More research is needed to find the cause for this decline in cognition.

show abstract

“…The cingulate gyrus is a key brain structure that regulates emotional information, learning, and memory (4). Using functional magnetic resonance imaging (fMRI), a few studies have revealed that the abnormal function of the cingulate gyrus may play a significant role in cognitive dysfunction in ESRD patients (5,6). The amplitude of low-frequency fluctuations (ALFF) in fMRI reflects the energy of signal fluctuations in the low-frequency range (0.01-0.1 Hz) at the voxel level in blood oxygen level-dependent functional magnetic resonance imaging (BOLD-fMRI) (7).…”

Section: Introductionmentioning

confidence: 99%

The relationship between abnormal cortical activity in the anterior cingulate gyrus and cognitive dysfunction in patients with end- stage renal disease: a fMRI study on the amplitude of low- frequency fluctuations

Gu¹,

Lu²,

Zhou

et al. 2020

Ann Palliat Med

View full text Add to dashboard Cite

Background: End-stage renal disease (ESRD) patients often have cognitive dysfunction. The abnormal changes in the brains of ESRD patients are difficult to detect with routine imaging examination. Cognitive performance scales are also not an ideal tool because assessments using these scales can be subjective and might be difficult to administer in some ESRD patients. Functional magnetic resonance has the advantages of non-radiation, multidirectional imaging, good repeatability. Using resting-state functional magnetic resonance imaging (rs-fMRI) and an amplitude of low-frequency fluctuation (ALFF) algorithm, this study characterized spontaneous brain activity and explored its relationship with cognitive function in ESRD patients. The aim of this study was to provide objective functional imaging evidence to reveal the pathophysiological mechanism of cognitive dysfunction in ESRD patients. Methods: This study recruited 35 ESRD patients and 25 healthy controls (HC) who were matched to the ESRD group by age, sex, and years of education. All study subjects were examined by Montreal Cognitive Assessment (MoCA) and rs-fMRI. Data Processing & Analysis of Brain Imaging (DPABI) V4.3 software was used to preprocess the data to obtain ALFF maps. The ALFF value of the cingulate gyrus was compared between the ESRD and HC groups. Subsequently, the correlation between the ALFF value of the cingulate gyrus and the MoCA score was analyzed in ESRD patients. Results: Compared with the HC group, the ESRD group had a significantly lower MoCA score (P<0.05). The ALFF values of the anterior and middle cingulate gyri were significantly lower in the ESRD patients (Gaussian random field (GRF) corrected, voxel-level significance: P<0.001, cluster-level significance: P<0.05). No increased ALFF was observed in any brain regions. The ALFF values of the bilateral anterior cingulate gyri were positively correlated with the MoCA scores (r=0.768, 0.625, GRF corrected, voxel-level significance: P<0.01, cluster-level significance: P<0.05).Conclusions: Patients with ESRD showed impaired spontaneous brain activity in the bilateral anterior and middle cingulate gyri, suggesting that ALFF of the anterior cingulate gyrus may be an imaging indicator of cognitive dysfunction in ESRD patients.

show abstract

Altered long- and short-range functional connectivity in the patients with end-stage renal disease: a resting-state functional MRI study

Cited by 19 publications

References 44 publications

Altered functional connectivity density in the brains of hemodialysis end-stage renal disease patients: An in vivo resting-state functional MRI study

Altered functional connectivity density in the brains of hemodialysis end-stage renal disease patients: An in vivo resting-state functional MRI study

Cognitive Function Declines Significantly during Haemodialysis in a Majority of Patients: A Call for Further Research

The relationship between abnormal cortical activity in the anterior cingulate gyrus and cognitive dysfunction in patients with end- stage renal disease: a fMRI study on the amplitude of low- frequency fluctuations

Contact Info

Product

Resources

About