2004
DOI: 10.1203/01.pdr.0000136276.52104.61
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Altered Lung Development after Prenatal Nicotine Exposure in Young Lambs

Abstract: There is compelling evidence that prenatal nicotine exposure permanently alters lung development and airway function. The aim of this study was to determine how prenatal nicotine exposure alters proximal and distal airway function. Thirteen lambs were continuously exposed during the last fetal trimester to low-dose nicotine (LN) and 12 to a moderate dose (MN) (maternal s.c. dose: 0.5 and 1.5 mg/kg/d, respectively). Ten lambs served as controls (C). Proximal airway function was measured by lung mechanics. A mul… Show more

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Cited by 38 publications
(33 citation statements)
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“…The maternal rat plasma concentrations of low nicotine 0.5-0.75 mg/kg/day and moderate nicotine 1.5 mg/kg/ day doses correspond to those observed in human light smokers smoking (˂10 cigarettes/d) (approximately 20 cigarettes /d), respectively [9].…”
Section: Electron Microscope Examinationsupporting
confidence: 52%
“…The maternal rat plasma concentrations of low nicotine 0.5-0.75 mg/kg/day and moderate nicotine 1.5 mg/kg/ day doses correspond to those observed in human light smokers smoking (˂10 cigarettes/d) (approximately 20 cigarettes /d), respectively [9].…”
Section: Electron Microscope Examinationsupporting
confidence: 52%
“…Epithelial cells directly exposed to smoke may experience nicotine levels that are 5-10-fold greater (40). Exposure to cigarette smoke during pregnancy adversely affects lung development as manifested by altered pulmonary function (41), increased respiratory illness (42), significantly reduced branching morphogenesis (43), and permanent airway obstruction in the proximal lung (44). Nicotine crosses the placenta and directly affects lung development in utero via an interaction with nAChRs in the developing and postnatal lung.…”
Section: Discussionmentioning
confidence: 99%
“…NRT use during pregnancy and breast-feeding when the neonate lungs are still developing should be avoided (Alm, Lagercrantz, & Wennergren, 2006). Prenatal nicotine exposure can permanently alter lung development and airway function (Sandberg, Poole, Hamdan, Arbogast, & Sundell, 2004). Prenatal and postnatal nicotine exposure have been causally implicated in Sudden Infant Death Syndrome (SIDS) (Cohen et al, 2002;Huang, Wang, Dergacheva, & Mendelowitz, 2005;McMartin et al, 2002;Milerad, Vege, Opdal, & Rognum, 1998; US Department of Health and Human Services, 2006).…”
Section: Nicotine In Pregnancy and Childhoodmentioning
confidence: 99%