1992
DOI: 10.1089/vim.1992.5.201
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Altered Macrophage Antigen-Presenting Cell Function Following Friend Leukemia Virus Infection

Abstract: To investigate the mechanism by which Friend leukemia virus (FV) causes immunosuppression, the ability of peritoneal macrophages to mediate antigen-specific T-cell activation following FV infection was examined. Decreased IL-2 production was observed when antigen-primed T cells were cultured with antigen-pulsed macrophages from mice infected with FV, compared to T cells cultured with macrophages from control mice. Macrophages from FV-infected mice demonstrated decreased phagocytic and pinocytic activity, sugge… Show more

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Cited by 5 publications
(4 citation statements)
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“…Bendinelli and coworkers (10) have shown that mice develop an enhanced antibody response to sheep red blood cells (SRBC) when injected with the appropriate number of syngeneic macrophages together with antigen. Positive identification of infected macrophages and altered macrophage antigenpresenting cell function following a Friend leukaemia virus (FV) infection have been reported (31). Our findings diverge from these reports.…”
Section: Discussioncontrasting
confidence: 99%
“…Bendinelli and coworkers (10) have shown that mice develop an enhanced antibody response to sheep red blood cells (SRBC) when injected with the appropriate number of syngeneic macrophages together with antigen. Positive identification of infected macrophages and altered macrophage antigenpresenting cell function following a Friend leukaemia virus (FV) infection have been reported (31). Our findings diverge from these reports.…”
Section: Discussioncontrasting
confidence: 99%
“…FV is an immunosuppressive retroviral complex that induces lethal disease in adult immunocompetent mice [18][19][20] . It comprises a replication-competent nonpathogenic helper virus, F-MuLV, and a replication-defective but pathogenic spleen focus-forming virus, SFFV (ref.…”
mentioning
confidence: 99%
“…Binding of the Ly-49A receptor on NK cells to H-2D d molecules can induce global down-regulation of NK cell-mediated killing (71), and decreased NK activity has been associated with FV infection (63). FV-immunosuppressed mice also have been reported to have impaired antigen presentation by macrophages (72). Important to note, susceptibility to immunosuppression does not preclude successful treatment by immunotherapy (58) or protection by vaccination (42).…”
mentioning
confidence: 99%