Altered metabolism of copper, zinc, and magnesium is associated with increased levels of glycated hemoglobin in patients with diabetes mellitus

Viktorínová, Alena; Tǒserová, Eva; Križko, M; Ďuračková, Zdeňka

doi:10.1016/j.metabol.2009.04.035

Cited by 179 publications

(148 citation statements)

References 29 publications

Supporting

Mentioning

120

Contrasting

Unclassified

Order By: Relevance

“…Previous researchers have suggested an interrelationship between diabetes and various micronutrients, including Mg, Cr, Fe, Zn, Cu, etc. Moreover, several studies have shown an increased lipid peroxidation in clinical and experimental diabetes (Niskanen et al 1995;Kakar et al 1998;Viktorínová et al 2009). However, nearly of all these studies are separate studies demonstrating the effects of diabetes on oxidative stress or metabolism of some elements.…”

Section: Discussionmentioning

confidence: 99%

“…However, it is not completely understood how hyperglycemia leads to increase in oxidative stress Zheng et al 2008;Wei et al 2009). The contribution of other factors, including the alternations in the homeostasis ions of some trace and transition elements as Fe and Cu on the occurrence and progression of the disease is still being discussed in literature (Eaton and Qian 2002;Viktorínová et al 2009). In the presence of certain metals (particularly iron or copper ions), a hydroxyl radical, which is the most powerful ROS, can be produced via the Fenton or the metal-catalyzed HaberWeiss reaction (Repetto et al 2010).…”

mentioning

confidence: 99%

See 1 more Smart Citation

Evaluation of trace elements and oxidative stress levels in the liver and kidney of streptozotocin-induced experimental diabetic rat model

Özçelik¹,

Tunçdemi̇r²,

Öztürk³

et al. 2012

gpb

View full text Add to dashboard Cite

Abstract. In this study, we aimed to investage the relationship among trace elements (Cu, Fe, Zn and Mg) on oxidative and anti-oxidative substances in liver and kidneys tissues in streptozotocin (STZ) diabetic rat model. The mean levels of Fe and Cu were found significantly higher in the liver and kidneys of the diabetic rats, in comparison to the control rats. On the other hand, the mean levels of Zn and Mg in the liver and kidneys of the diabetic rats were significantly lower than in the control rats.The liver and kidneys malonaldehyde (MDA) levels of the experimental group were found to be higher than in the control group (p < 0.001; p < 0.01, respectively) after 4 weeks of the experimental period. Superoxide dismutase (SOD) activities and glutathione (GSH) levels in the liver tissue of STZ-induced diabetic rats were found to be lower in the experimental group than in the control group (p < 0.01). SOD activity and GSH concentration in kidneys of the diabetic rats were significantly diminished with respect to the control group (p < 0.01). In conclusion, the present results indicate that the increase of Fe and Cu together with decreas of Zn and Mg concentration in liver and kidney of STZ-induced diabetic rats may be involved in disturbances of oxidative balance in both the tissues. Therefore, these findings may contribute to explain the role of impaired ion metabolism of some elements in the progression of diabetic oxidative complications.

show abstract

Section: Discussionmentioning

confidence: 99%

mentioning

confidence: 99%

Evaluation of trace elements and oxidative stress levels in the liver and kidney of streptozotocin-induced experimental diabetic rat model

Özçelik¹,

Tunçdemi̇r²,

Öztürk³

et al. 2012

gpb

View full text Add to dashboard Cite

show abstract

“…It plays an important role in the activities of various enzymes which are involved in glucose oxidation, and it may play a role in the release of insulin [17][18][19]. It is mainly intracellular and its uptake is stimulated by insulin [19,20].…”

Section: Discussionmentioning

confidence: 99%

Trace Elements in Diabetes Mellitus

Praveeena¹,

Pasula²,

K³

2013

JCDR

View full text Add to dashboard Cite

Introduction: Diabetes Mellitus is the commonest major metabolic disease and most prevalent diseases worldwide. Its related morbidity is due to its micro and macro angiopathic complications. Aim:The aim of this study was to measure and compare the serum levels of zinc and magnesium in normal individuals and in diabetic patients.Method: Analysis of minerals was done in plasma by using a Varian Spectra AA 220 model atomic absorption spectrophotometer. Result:Our observations showed a definite lowering of serum magnesium (p<0.001) and serum zinc levels (p<0.001) were significant in diabetic group. Conclusion:The cause of diabetic hypomagnesaemia is multifactorial. An altered metabolism, a poor glycaemic control and osmotic diuresis may be contributory factors. Decreased serum zinc levels in diabetes may be caused by an increase in urinary loss. These decreased levels of trace elements cause disturbances in glucose transport across cell membrane lead to insufficient formation and secretion of insulin by pancreas which compromise in the antioxidant defense mechanisms.

show abstract

“…Viktorínová et al 24) reported that there no significant differences in the plasma concentrations of Cu, Zn and Mg between type 1 (n=11) and type 2 (n=25) diabetic patients. Furthermore, they reported no differences in those elements in between type 2 patients taking insulin and taking oral antidiabetic agents.…”

Section: Discussionmentioning

confidence: 96%

Essential and Non-essential Elements in Scalp Hair of Diabetics: Correlations with Glycated Hemoglobin (HbA1c)

Hotta

Fujino

Kimura

et al. 2018

Biological & Pharmaceutical Bulletin

View full text Add to dashboard Cite

Essential elements (Ca, Mg, Zn, Cu, Fe, Cr, Mn and V) and non-essential elements (As, Cd, Hg and Pb) were measured in scalp hair samples of 45 diabetic subjects and 59 control subjects in Japan using inductively coupled plasma mass spectrometry. All diabetic subjects took insulin and/or antidiabetic agents, with glycated hemoglobin (HbA1c) ranging between 6.2 and 14.4%. The levels of Zn, Cu and Cr in the diabetic subjects (HbA1c>7) were significantly lower than those in the control subjects (p<0.05), and these concentrations decreased significantly with increases in HbA1c (p<0.01). The levels of Fe and Mg in the diabetic subjects were insignificantly lower, and the concentration of Fe decreased significantly with increases in HbA1c (p<0.05) and the concentration of Mn tended to decrease (p<0.10). In contrast, the concentration of As tended to increase with increases in HbA1c ( p<0.10). The concentrations of other elements, such as Ca, Mn, V, Pb, Cd and Hg, in the diabetic subjects were similar to those of control subjects, and did not correlate with HbA1c. The average of estimated glomerular filtration rate (eGFR) in the diabetic subjects was 77.7 29.7 mL/min/1.73 m 2 with large variation (12.7-148 mL/min/1.73 m 2 ), and previous study reported the increase of urinary excretion of Zn, Cr, Mn and Mg in diabetic subjects. The decreases of Zn, Cu, Cr, Fe and Mg concentrations in hair may reflect increased urinary excretion of these elements due to diabetic nephropathy.Key words diabetes; scalp hair; glycated hemoglobin (HbA1c); zinc; chromium; copper Diabetes mellitus is a serious and chronic metabolic disorder. Type 2 diabetes results from a disruption in glucose metabolism associated with a reduction in insulin production and utilization by tissues. Glycated hemoglobin (HbA1c) levels are used for screening and diagnostic purposes as HbA1c indicates the quality of blood glucose control over the previous 1-2 or 2-3 months. A HbA1c (%) value greater than 6.5 is a cut-off point for diabetic subjects and is highly prognostic for longterm diabetes-related complications such as nephropathy, retinopathy and neuropathy, and maintenance of the HbA1c value below 7.0 is a therapeutic guideline for the prevention of such complications of the Japan Diabetic Society. Estimated glomerular filtration rate (eGFR) is used for screening for nephropathy. The glomerular filtration rate (GFR) generally decreases as diabetes progresses, but the early stage of diabetic nephropathy is characterized by hyperfiltration (increase of GFR). 1) Deficiencies in trace elements such as Cr, Zn, Cu, Mg and Mn have been shown to predispose a person to glucose tolerance and to promote the development of diabetic complications. 2,3) Insulin resistance (IR) is defined as the condition in which insulin sensitive tissues become numb to insulin reception, and a Cr deficiency can induce IR. 2) Zn is known to synthesize insulin as well as stabilize insulin that has been stored in the beta cells of the pancreas. 4) Further, Zn has an important role in the sec...

show abstract

Altered metabolism of copper, zinc, and magnesium is associated with increased levels of glycated hemoglobin in patients with diabetes mellitus

Cited by 179 publications

References 29 publications

Evaluation of trace elements and oxidative stress levels in the liver and kidney of streptozotocin-induced experimental diabetic rat model

Evaluation of trace elements and oxidative stress levels in the liver and kidney of streptozotocin-induced experimental diabetic rat model

Trace Elements in Diabetes Mellitus

Essential and Non-essential Elements in Scalp Hair of Diabetics: Correlations with Glycated Hemoglobin (HbA1c)

Contact Info

Product

Resources

About

Altered metabolism of copper, zinc, and magnesium is associated with increased levels of glycated hemoglobin in patients with diabetes mellitus

Cited by 179 publications

References 29 publications

Evaluation of trace elements and oxidative stress levels in the liver and kidney of streptozotocin-induced experimental diabetic rat model

Evaluation of trace elements and oxidative stress levels in the liver and kidney of streptozotocin-induced experimental diabetic rat model

Trace Elements in Diabetes Mellitus

Essential and Non-essential Elements in Scalp Hair of Diabetics: Correlations with Glycated Hemoglobin (HbA1c)

Contact Info

Product

Resources

About

Evaluation of trace elements and oxidative stress levels in the liver and kidney of streptozotocin-induced experimental diabetic rat model

Evaluation of trace elements and oxidative stress levels in the liver and kidney of streptozotocin-induced experimental diabetic rat model