Altered molecular pattern of mucosal healing in Crohn’s disease fibrotic stenosis

Serum Syndecan-1 Levels and Its Relationship to Disease Activity in Patients with Crohn’s Disease

“…In addition, SDC-1 is an effective factor in the fibroblast proliferation and fibrosis development via transforming growth factor-beta (TGF- β ) [ 5 ]. Ierardi et al detected increased bFGF and SDC-1 levels in the resection specimens from CD patients with surgical resection secondary to fibrotic strictures in their study [ 20 ]. In the light of these data, low serum levels of SDC-1 in stricturing CD can be regarded as indirect evidence of less shedding of mucosal SDC-1 and higher levels of mucosal SDC-1 in our study.…”

Expression of basic fibroblastic growth factor, syndecan 1 and tumour necrosis factor α in resected acute colonic diverticulitis

“…When it is not activated by SD1, bFGF may be destroyed by luminal and circulating proteases and is therefore not available for mucosal regeneration . These molecules are also involved in tissue repair and healing in CD , and it is known that the imbalance between these molecules may be related to inflammation and fibrosis .…”

Chronic diverticulitis and Crohn's disease share the same expression of basic fibroblastic growth factor, syndecan 1 and tumour necrosis factor-α

“…We know that the imbalance among TNF-α, SD1, and bFGF may be related to inflammation and fibrosis in CD 5. We found recently that TNF-α and bFGF expressions are significantly overexpressed in AUD and ACD,6 7 confirming the hypothesis that inflammation may activate the fibrosis process.…”

“…Basic fibroblast growth factor (bFGF) is a peptide able to repair ulcerative lesions due to its capacity to bind epithelial and stromal cells 4. These molecules are involved in tissue repairs and healing in CD, and their microimbalance may be related to inflammation and fibrosis 5. We have recently found that TNF-α, SD1 and bFGF are overexpressed in AUD6 and in ACD,7 but no information is currently available about the expression of these molecules in CDiv.…”