Altered Monocyte Cyclooxygenase Response to Lipopolysaccharide in Type 1 Diabetes

Beyan, Huriya; Goodier, Martin R.; Nawroly, Niga; Hawa, M.; Bustin, Stephen A.; Ogunkolade, W; Londei, Marco; Yousaf, Nasim; Leslie, Richard

doi:10.2337/db06-0447

Cited by 26 publications

(21 citation statements)

References 32 publications

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“…A number of the inflammatory changes in T1D are detected at the level of monocyte cell. For example, up-regulation of the adhesion molecule CD11b (Mac-1) has been demonstrated [8] in addition to aberrant constitutive and LPS-stimulated expression of cyclooxygenase (COX)-2, a defect that may predispose to a chronic inflammatory response in T1D [30,31]. The vascular endothelium represents a likely target of this inflammatory response detected in patients with T1D.…”

Section: Discussionmentioning

confidence: 99%

C-peptide reduces pro-inflammatory cytokine secretion in LPS-stimulated U937 monocytes in condition of hyperglycemia

et al. 2011

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Section: Discussionmentioning

confidence: 99%

C-peptide reduces pro-inflammatory cytokine secretion in LPS-stimulated U937 monocytes in condition of hyperglycemia

et al. 2011

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“…Interestingly, elevated circulating levels of the pro-inflammatory cytokine interleukin (IL)-8 were found in children with recentonset T1DM (<1year), who were also overweight [9]. Other evidence of monocyte involvement in T1DM includes studies showing aberrant constitutive and lipopolysaccharide (LPS)-stimulated expression of monocyte cyclooxygenase (COX)-2 expression in monocytes of T1DM patients, a defect which may predispose to a chronic inflammatory response in T1DM [4,10]. The direct consequences of monocyte activation in T1DM are unknown, but theoretically could involve release of pro-inflammatory cytokines and endothelial activation with increased monocyte adherence to the vascular endothelium, such as that of the pancreatic islets or kidney and retinal capillaries.…”

Section: Introductionmentioning

confidence: 99%

Increased Expression of Monocyte CD11b (Mac-1) in Overweight Recent-Onset Type 1 Diabetic Children

Cifarelli¹,

Libman²,

Luca³

et al. 2007

Rev Diabet Stud

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■ AbstractAIM: Compelling evidence implicates inflammation in the pathogenesis of type 1 diabetes mellitus (T1DM) and associated vascular complications. Obesity is also characterized by low-grade systemic inflammation. In this study, we characterized the inflammatory response in diabetes by analyzing the expression of a panel of activation markers on the surface of peripheral blood monocytes in recently-diagnosed T1DM patients. The potential effects of glycemic control and of body mass index (BMI) on monocyte phenotype was also investigated. METHODS: Using flow cytometry, we analyzed the expression of CD11b, CD49d, CD54, CD62L, and CD64 antigens on monocytes in a cohort of 51 T1DM patients (≤ 2 months after diagnosis). RESULTS: We found that circulating monocytes from T1DM patients tested at the clinical onset of the disease (i.e. within 1 week of diagnosis) had higher CD11b expression compared to patients analyzed 2 months after diagnosis (p = 0.02). The highest CD11b levels were detected in patients with HbA1c > 8% (p = 0.04 vs. patients with HbA1c < 8%). In T1DM children analyzed 2 months after diagnosis, we found that those who were overweight (BMI ≥ 85 th percentile) had higher levels of monocyte activation than those who were not overweight (BMI ≤ 85 th percentile) (p = 0.03). CD11b and HbA1c were significantly correlated (correlation coefficient 0.329, p = 0.02). CONCLUSIONS: Circulating immune cells from T1DM patients display many aspects of a proinflammatory state, as indicated by primed or activated monocytes. Obesity is an important factor in monocyte activation during diabetes.

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“…Owing to their chemotactic activity on fibroblasts, myocytes, and inflammatory cells, BMPs were also considered to influence inflammatory processes in adults [8]. Bone morphogenetic protein 4 (BMP4), a member of the BMPs family, is primarily expressed in airway epithelial cells and plays a key role in the early stage of lung development [9]. BMP4 was demonstrated being upregulated in ovabumin-induced inflammation in mouse lung [8].…”

Section: Introductionmentioning

confidence: 99%

Bone morphogenetic protein 4 inhibits liposaccharide‐induced inflammation in the airway

Wang

et al. 2014

Eur J Immunol

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Bone morphogenetic protein 4 (BMP4) is a multifunctional growth factor that belongs to the TGF-β superfamily. The role of BMP4 in lung diseases is not fully understood. Here, we demonstrate that BMP4 was upregulated in lungs undergoing lipopolysaccharide (LPS)-induced inflammation, and in airway epithelial cells treated with LPS or TNF-α. BMP4 mutant (BMP4 Keywords: Airway inflammation r BMP4 r LPS r Lung function r Pseudomonas aeruginosaAdditional supporting information may be found in the online version of this article at the publisher's web-site IntroductionInflammation is a complex response that can be both defensive and harmful to the body. Although the primary role of inflammaCorrespondence: Prof. Wenju Lu e-mail: wlu92@yahoo.com tion is to eliminate the detrimental factors in tissues, the out-ofcontrolled inflammatory responses will lead to tissue damage that is even more harmful than the primary disease condition. Establishment of inflammatory cascades includes the release of both * These authors contributed equally to this work.C 2014 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim www.eji-journal.eu 3284 Zhengtu Li et al. Eur. J. Immunol. 2014. 44: 3283-3294 pro-and anti-inflammatory mediators and the maturation, activation, and migration of the responding inflammatory cells [1]. The excessive inflammation in the lung causes lung injury that includes reduced alveolar-capillary barrier function, increased pulmonary vascular permeability, leukocyte infiltration into the alveolar space, etc. [2]. If the inflammatory factors cannot be cleared out timely, it makes the acute inflammation turn into chronic condition [3]. Accumulating evidence indicates that transforming growth factor β (TGF-β) plays a determining role in regulating both innate and acquired immunity [4]. TGF-β1 null mice exhibit widespread lethal inflammation in tissue, primarily in the heart and lung [5]. In addition, TGF-β1 stimulates fibroblast proliferation, promoting airway remodeling during chronic lung inflammation associated with asthma and chronic obstructive pulmonary disease (COPD) [6]. Bone morphogenetic proteins (BMPs) are multifunctional growth factors that belong to TGF-β superfamily members [7]. Owing to their chemotactic activity on fibroblasts, myocytes, and inflammatory cells, BMPs were also considered to influence inflammatory processes in adults [8]. Bone morphogenetic protein 4 (BMP4), a member of the BMPs family, is primarily expressed in airway epithelial cells and plays a key role in the early stage of lung development [9]. BMP4 was demonstrated being upregulated in ovabumin-induced inflammation in mouse lung [8]. However, the role of BMP4 in lung inflammation, particularly in lung innate immunity is unknown.In this study, we hypothesized that BMP4 might participate in regulating the innate immune responses to bacterial infection. We examined the lung BMP4 expression during LPS-induced inflammation. Moreover, we compared the LPS-induced and Pseudomonas aeruginosa (PA) induced airway inflammation and pulmonary bacterial...

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Altered Monocyte Cyclooxygenase Response to Lipopolysaccharide in Type 1 Diabetes

Cited by 26 publications

References 32 publications

C-peptide reduces pro-inflammatory cytokine secretion in LPS-stimulated U937 monocytes in condition of hyperglycemia

C-peptide reduces pro-inflammatory cytokine secretion in LPS-stimulated U937 monocytes in condition of hyperglycemia

Increased Expression of Monocyte CD11b (Mac-1) in Overweight Recent-Onset Type 1 Diabetic Children

Bone morphogenetic protein 4 inhibits liposaccharide‐induced inflammation in the airway

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