2017
DOI: 10.1016/j.dld.2016.12.022
|View full text |Cite
|
Sign up to set email alerts
|

Altered mucosal expression of microRNAs in pediatric patients with inflammatory bowel disease

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...
2
1
1

Citation Types

0
24
0
2

Year Published

2018
2018
2024
2024

Publication Types

Select...
7
1

Relationship

0
8

Authors

Journals

citations
Cited by 30 publications
(26 citation statements)
references
References 61 publications
0
24
0
2
Order By: Relevance
“…Statistical significance was defined as p < 0.05. AU = arbitrary units (which represent the expression of each miR normalized toU6sn RNA internal control), miR = microRNA data supporting its usefulness as a CD specific diagnostic marker, both in adults and children [62,75]. In contrast to human studies, we found decreased relative expression in the colonic mucosa of dogs with IBD compared to healthy controls.…”
Section: Discussionmentioning
confidence: 49%
“…Statistical significance was defined as p < 0.05. AU = arbitrary units (which represent the expression of each miR normalized toU6sn RNA internal control), miR = microRNA data supporting its usefulness as a CD specific diagnostic marker, both in adults and children [62,75]. In contrast to human studies, we found decreased relative expression in the colonic mucosa of dogs with IBD compared to healthy controls.…”
Section: Discussionmentioning
confidence: 49%
“…We and others have identified miR-31 as a discriminant more generally of CD and NIBD patients (11,12). We hypothesized that this difference is driven primarily by CD patients in the IL group.…”
Section: Resultsmentioning
confidence: 88%
“…In a study on patients with Crohn's disease, miRNA-204 expressions were found to be increased in the affected intestinal mucosa. 18 Conversely, Lai et al 19 have found that the plasma miRNA-204 levels were lower in patients with RA and it was increased after anti-TNF-alpha treatment. In a current research, Koga et al 20 have demonstrated that miRNA-204 is significantly decreased in plasma of FMF patients.…”
Section: Discussionmentioning
confidence: 99%
“…6 Serum miRNA-204 levels were commonly studied in different types of cancer, rheumatoid arthritis (RA) and various inflammatory diseases, with significant alterations detected in plasma expression. [14][15][16][17][18][19] Moreover, the miRNA-204 was demonstrated to have suppressor effects on inflammatory cytokine production by targeting the phosphoinositide 3-kinase gamma (PI3Kg) pathway and that plasma miR-204 level can be used as a potential biomarker in patients with FMF. 20 Rosenberger et al 21 have shown that miRNA-451 has a role in cytokine production in dendritic cells.…”
mentioning
confidence: 99%