Altered muscle insulin sensitivity in the male offspring of protein-malnourished rats

Ozanne, Susan E.; Wang, C. L.; Coleman, Nick; Smith, Geoffrey D.

doi:10.1152/ajpendo.1996.271.6.e1128

Cited by 153 publications

(157 citation statements)

References 14 publications

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“…However, this finding is in accordance with findings in animal models showing transient improved glucose tolerance and insulin sensitivity among young (3 months) male offspring of protein-malnourished rats [25,26]. These studies in rats together with our findings in humans indicate the important role of age in unmasking the impact of an adverse intrauterine environment for the development of insulin resistance.…”

Section: Discussionsupporting

confidence: 92%

“…Age could be one of the most important factors precipitating the metabolic abnormalities characterising Type II diabetes [23,24], and the influence of the intrauterine environment for the development of insulin resistance and other metabolic abnormalities could vary with age potentially becoming more pronounced with increasing age as indicated in a few rodent studies [25,26].…”

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confidence: 99%

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Age-dependent impact of zygosity and birth weight on insulin secretion and insulin action in twins

et al. 2002

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Aims/hypothesis. Study the influence of age, zygosity and birth weight on insulin action and insulin secretion in twins. Methods. In vivo insulin action and insulin secretion were measured using the euglycaemic, hyperinsulinaemic clamp technique and intravenous glucose tolerance test, respectively. We examined 104 monozygotic (MZ) twins and 88 dizygotic (DZ) twins in two age groups (25-34 and 57-66 years).Results. There were no differences in birth weight, body mass index, waist to hip ratio or lean body mass between monozygotic and dizygotic twins. Younger monozygotic twins had a slightly higher insulin-stimulated glucose uptake (M) than younger dizygotic twins. In contrast, elderly monozygotic twins had a lower insulin-stimulated glucose uptake value compared with elderly dizygotic twins. Elderly monozygotic twins had a reduced insulin secretion relative to insulin resistance compared to dizygotic twins during oral glucose tolerance test (OGTT). Birth weight per se was not associated with insulin secretion or action in the twins. However, correcting for the genetic influence on birth weight using intrapair differences among monozygotic twin pairs, low birth weight was associated with insulin resistance and low insulin secretion after both oral and intravenous glucose administration in elderly MZ twins. Conclusion/interpretation. Zygosity status has a major age (or time) dependent impact on in vivo insulin secretion and insulin action in twins independent of birth weight and adult antropometry. An additional non-genetic impact of low birth weight on insulin secretion and insulin action was found in elderly monozygotic twins. Ageing could play an important role by unmasking the influence of an adverse intrauterine environment on insulin resistance and low insulin secretion in twins. [Diabetologia (2002[Diabetologia ( ) 45:1649[Diabetologia ( -1657

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Section: Discussionsupporting

confidence: 92%

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confidence: 99%

Age-dependent impact of zygosity and birth weight on insulin secretion and insulin action in twins

et al. 2002

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“…Despite the blunted insulin release, the fasting plasma glucose level was only slightly increased, and plasma glucose remained normal during the OGTT. Normal glucose tolerance with reduced insulin secretion can be explained by an adaptation of peripheral tissues to lower insulin levels, as shown previously [38,39,40].…”

Section: Discussionmentioning

confidence: 57%

Effect of maternal low-protein diet and taurine on the vulnerability of adult Wistar rat islets to cytokines

et al. 2004

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Aims/hypothesis. A maternal low-protein diet has been shown to induce an increased susceptibility of fetal islets to cytokines, but this effect can be avoided by maternal taurine supplementation. Here, we question whether these effects persist until adulthood in the offspring, despite the animal having a normal diet after weaning. Methods. Pregnant Wistar rats received a diet of either 20% or 8% protein (control [C group] and recuperated [R group] respectively), which was or was not supplemented with taurine (control treated with taurine [CT group] and recuperated treated with taurine [RT group] respectively) during gestation and lactation. When the female offspring reached adulthood, an OGTT was performed. In a second stage, islets were isolated from these offspring, then pretreated or not with taurine, and subsequently treated with cytokines. Results. Fasting glycaemia was higher (p<0.05) and insulinaemia was lower (p<0.01) in the R group than in the C group. Taurine supplementation decreased insulinaemia in the CT group and tended to increase it in the RT group. After the OGTT, glycaemia in R animals was not different from that in the C group, despite a blunted insulin response (p<0.05) which was restored by taurine. Supplementation in C-group mothers led to a weak glucose intolerance. In vitro, more apoptotic cells were observed in R islets after cytokines treatment (p<0.01). The addition of taurine to the culture medium in the R and C groups protected the islets from the cytokines (p<0.01). Maternal taurine supplementation decreased the sensitivity of islets in the RT group (p<0.01), but increased sensitivity in the CT group (p<0.01). Conclusions/interpretation. The increased vulnerability of islets to cytokines due to a restriction of protein during fetal development was still evident when the offspring reached adulthood. The low-protein diet also induced hyperglycaemia in the presence of lower insulinaemia. Taurine supplementation protected adult islets of the R group from cytokine toxicity and restored the insulinaemia. However, unnecessary supplementation of taurine could have detrimental effects.

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“…Increased expression of the insulin receptor [22,23,24] has been observed and this reversed with age [25] possibly providing part of the explanation of the change from increased to decreased insulin sensitivity with age.…”

Section: Studies In Vitromentioning

confidence: 97%

For Debate: Fetal and early postnatal growth restriction lead to diabetes, the metabolic syndrome and renal failure*

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Altered muscle insulin sensitivity in the male offspring of protein-malnourished rats

Cited by 153 publications

References 14 publications

Age-dependent impact of zygosity and birth weight on insulin secretion and insulin action in twins

Age-dependent impact of zygosity and birth weight on insulin secretion and insulin action in twins

Effect of maternal low-protein diet and taurine on the vulnerability of adult Wistar rat islets to cytokines

For Debate: Fetal and early postnatal growth restriction lead to diabetes, the metabolic syndrome and renal failure*

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