Altered neural activation pattern during teeth clenching in temporomandibular disorders

He, Shushu; Li, Fēi; Gu, Tian; Liu, Yi; Zou, Shujuan; Huang, Xiaoqi; Lui, Su; Gong, Qiyong; Chen, Song

doi:10.1111/odi.12465

Cited by 8 publications

(17 citation statements)

References 45 publications

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“…A total of 25 studies published between January 1, 2010 and August 3, 2019 were included (details in Tables 1 and 2 and Additional file 2). Twenty-four MRI studies [22,23,31,32,35,39,[41][42][43][45][46][47][48][49][50][51][52][53][54][55][56][57][58][59] compared patients with TMD and healthy controls, while 1 longitudinal study recruited only patients [60].…”

Section: Search Results and Study Characteristicsmentioning

confidence: 99%

“…Four studies [46][47][48][49] used resting-state fMRI (rs-fMRI) to evaluate spontaneous neural function and functional connectivity (FC). Nine studies [50][51][52][53][54][55][56][57]60] used task-state fMRI (ts-fMRI) to investigate regional changes in neural activity during pain perception and modulation, of which 1 study [51] combined resting and task state fMRI and 1 study [50] mixed 3 modalities of ts-fMRI, DTI, and arterial spin labeling (ASL). One study [23] used the single modality of ASL to measure CBF in the whole brain and the brainstem in two steps.…”

Section: Neuroimaging Methods Employed In the Reviewed Studiesmentioning

confidence: 99%

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The neuro-pathophysiology of temporomandibular disorders-related pain: a systematic review of structural and functional MRI studies

Yin

et al. 2020

J Headache Pain

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Chronic pain surrounding the temporomandibular joints and masticatory muscles is often the primary chief complaint of patients with temporomandibular disorders (TMD) seeking treatment. Yet, the neuro-pathophysiological basis underlying it remains to be clarified. Neuroimaging techniques have provided a deeper understanding of what happens to brain structure and function in TMD patients with chronic pain. Therefore, we performed a systematic review of magnetic resonance imaging (MRI) studies investigating structural and functional brain alterations in TMD patients to further unravel the neurobiological underpinnings of TMD-related pain. Online databases (PubMed, EMBASE, and Web of Science) were searched up to August 3, 2019, as complemented by a hand search in reference lists. A total of 622 papers were initially identified after duplicates removed and 25 studies met inclusion criteria for this review. Notably, the variations of MRI techniques used and study design among included studies preclude a meta-analysis and we discussed the findings qualitatively according to the specific neural system or network the brain regions were involved in. Brain changes were found in pathways responsible for abnormal pain perception, including the classic trigemino-thalamo-cortical system and the lateral and medial pain systems. Dysfunction and maladaptive changes were also identified in the default mode network, the top-down antinociceptive periaqueductal gray-raphe magnus pathway, as well as the motor system. TMD patients displayed altered brain activations in response to both innocuous and painful stimuli compared with healthy controls. Additionally, evidence indicates that splint therapy can alleviate TMD-related symptoms by inducing functional brain changes. In summary, MRI research provides important novel insights into the altered neural manifestations underlying chronic pain in TMD.

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Section: Search Results and Study Characteristicsmentioning

confidence: 99%

Section: Neuroimaging Methods Employed In the Reviewed Studiesmentioning

confidence: 99%

The neuro-pathophysiology of temporomandibular disorders-related pain: a systematic review of structural and functional MRI studies

Yin

et al. 2020

J Headache Pain

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“…The initial search revealed 246 articles and 18 articles that matched the eligibility criteria. The 18 articles consisted of 13 studies on chewing, [26][27][28][29][30][31][32][33][34][35] 7 studies on clenching [36][37][38][39][40][41] and 2 studies on teeth tapping, 42,43 in total 22 studies. The studies on teeth tapping were included in the qualitative meta-analysis analysis only, but not in the ALE meta-analysis, due to the small number of studies in this category.…”

Section: Results Of Literature Searchmentioning

confidence: 99%

Meta‐analysis of brain mechanisms of chewing and clenching movements

Lin

2018

J of Oral Rehabilitation

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Functional magnetic resonance imaging (fMRI) is widely used for investigating brain activation patterns associated with chewing and clenching movements. Whether studies consistently identify similar brain loci engaged in these movements remains unknown. We investigated the consistency with which specific brain loci were reported to be activated during teeth-occluding movements, using the activation likelihood estimation (ALE) meta-analysis. Twenty fMRI studies that used fMRI to investigate brain activation during a chewing or clenching task in healthy participants were included. Data from the selected studies were pooled, and ALE methods were used to estimate the likelihood of finding a locus associated with the movements. We found that (i) The bilateral primary motor cortex/supplementary motor area/thalamus, the right primary somatosensory cortex (S1)/secondary somatosensory cortex and the posterior cerebellum (lobule VI) have been identified as reliable loci that show consistently activation when teeth occlude. (ii) The right S1 showed a significant likelihood of activation associated with both chewing and clenching, while the left S1 showed a greater likelihood of activation in chewing than in clenching. (iii) Both younger and older participants showed a significant likelihood of activation in the cerebellum. No significant cluster was identified in the contrast analysis. The fMRI studies reliably identified the sensorimotor cortex, the thalamus and the cerebellum as brain loci associated with chewing and clenching and illustrated a differential activation pattern between chewing and clenching. These findings support the use of fMRI as a potential tool for assessing brain activation patterns related to oral sensorimotor functions in humans.

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“…Many studies on animals have shown that the daily hardness of food affected masseter muscle myosin composition. Furthermore, the type of daily diet also influenced the volume of their masticatory muscle fibers (He et al., ; Maeda et al., ). Additionally, previous reports have shown a reduction and degeneration of muscle fibers in murine masseter muscles subjected to a daily diet of soft foods (Maeda, Suwa, Ichikawa, Masuda, & Kumegawa, ; Maeda et al., ).…”

Section: The Human Masseter Musclementioning

confidence: 99%

Functional and molecular outcomes of the human masticatory muscles

et al. 2017

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The masticatory muscles achieve a broad range of different activities such as chewing, sucking, swallowing, and speech. In order to accomplish these duties, masticatory muscles have a unique and heterogeneous structure and fiber composition, enabling them to produce their strength and contraction speed largely dependent on their motor units and myosin proteins that can change in response to genetic and environmental factors. Human masticatory muscles express unique myosin isoforms, including a combination of thick fibers, expressing myosin light chains (MyLC) and myosin class I and II heavy chains (MyHC) -IIA, -IIX, α-cardiac, embryonic and neonatal and thin fibers, respectively. In this review, we discuss the current knowledge regarding the importance of fiber-type diversity in masticatory muscles versus supra- and infrahyoid muscles, and versus limb and trunk muscles. We also highlight new information regarding the adaptive response and specific genetic variations of muscle fibers on the functional significance of the masticatory muscles, which influences craniofacial characteristics, malocclusions, or asymmetry. These findings may offer future possibilities for the prevention of craniofacial growth disturbances.

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Altered neural activation pattern during teeth clenching in temporomandibular disorders

Cited by 8 publications

References 45 publications

The neuro-pathophysiology of temporomandibular disorders-related pain: a systematic review of structural and functional MRI studies

The neuro-pathophysiology of temporomandibular disorders-related pain: a systematic review of structural and functional MRI studies

Meta‐analysis of brain mechanisms of chewing and clenching movements

Functional and molecular outcomes of the human masticatory muscles

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