Altered Neural Correlate of the Self-Agency Experience in First-Episode Schizophrenia-Spectrum Patients: An fMRI Study

Španiel, Filip; Tintěra, Jaroslav; Rydlo, Jan; Ibrahim, Ibrahim; Kašpárek, Tomáš; Horáček, Jiří; Zaytseva, Yuliya; Matějka, Martin; Fialova, Marketa; Slováková, Andrea; Mikoláš, Pavol; Melicher, Tomáš; Görnerova, Natalie; Höschl, Cyril; Hájek, Tomáš

doi:10.1093/schbul/sbv188

Cited by 31 publications

(19 citation statements)

References 60 publications

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“…Backasch et al showed low functional connectivity between the inferior frontal gyrus and some regions (the insula, putamen, and medial orbitofrontal cortex) in schizophrenia by using their own agency task with unintentional movement and delayed visual feedback (20). Spaniel et al demonstrated an impaired default mode and central executive networks dynamic switching in schizophrenia by using their own agency task with incongruent visual feedback (37). Although their task designs were useful for evaluating one neural network, they did not target the learning process in agency adaptation.…”

Section: Introductionmentioning

confidence: 99%

Dysconnectivity of the Agency Network in Schizophrenia: A Functional Magnetic Resonance Imaging Study

et al. 2019

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Background: Self-disturbances in schizophrenia have recently been explained by an abnormality in the sense of agency (SoA). The cerebral structures of SoA in healthy people are considered to mainly include the insula and inferior parietal lobule. In contrast, the functional lesion of aberrant SoA in schizophrenia is not yet fully understood. Considering the recent explanation of establishing SoA from the standpoint of associative learning, the “agency network” may include not only the insula and inferior parietal lobule but also the striatum. We hypothesized that aberrant SoA in schizophrenia is based on a deficit in the “agency network.” Methods: Functional magnetic resonance imaging data were acquired while patients with schizophrenia ( n = 15) and matched controls ( n = 15) performed our adaptation method of agency attribution task on a trial-by-trial basis to assess participants' explicit experience of the temporal causal relationship between an action and an external event with temporal biases. Analysis of functional connectivity was done using the right supramarginal gyrus and the right middle frontal gyrus as seed regions. Results: In healthy controls, analyses revealed increased activation of the right inferior parietal lobule (mainly the supramarginal gyrus), right insula, and right middle frontal gyrus as an activation of the agency condition. We defined activated Brodmann areas shown in the agency condition of healthy controls as the seed region for connectivity analysis. The connectivity analysis revealed lower connectivity between the head of the left caudate nucleus and right supramarginal gyrus in the patients compared to healthy controls. Conclusions: This dysconnectivity of the agency network in schizophrenia may lead to self-disturbance through deficits in associative learning of SoA. These findings may explain why pathological function of the striatum in schizophrenia leads to self-disturbance.

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Section: Introductionmentioning

confidence: 99%

Dysconnectivity of the Agency Network in Schizophrenia: A Functional Magnetic Resonance Imaging Study

et al. 2019

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“…Furthermore, an extensive body of research suggested that inferior parietal cortical, including angular gyrus activation reflected the experiences of agency by processing action signals generated in the frontal cortex (Renes, van Haren, Aarts, & Vink, 2015;Maurer et al, 2016;Voss, Chambon, Wenke, Kuhn, & Haggard, 2017). Other studies implicated the default mode network (Fukushima, Goto, Maeda, Kato, & Umeda, 2013;de Bezenac, Sluming, Gouws, & Corcoran, 2016;Spaniel et al, 2016). A meta-analysis suggested the role of the insula in self-agency across multiple behavioral tasks (Sperduti, Delaveau, Fossati, & Nadel, 2011).…”

Section: Introductionmentioning

confidence: 99%

Cerebral responses to self-initiated action during social interactions

Wang

Zhornitsky

et al. 2019

Cogn Affect Behav Neurosci

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Social interaction involves self-initiated actions that engage subjective awareness of one's own volition. Individuals with social communication needs or social anxiety find it particularly difficult to initiate social interactions. However, extant studies have not specifically addressed how perceived exclusion may influence self-initiated actions during social interaction. As a first step to address this question, we scanned 24 healthy adults participating in a Cyberball game with two fictive players. By contrasting events of observing, receiving, and initiating ball toss during a scenario of fair game (FG) and of exclusion (EX), we examined the neural correlates of self-initiated action during social interactions. Behaviorally, participants were faster in catching but slower in tossing the ball in EX compared with FG, suggesting a burden during self-initiated actions during social exclusion. Tossing versus receiving (or observing) engaged higher activity during EX than FG in the precuneus and angular gyrus, regions that have been widely implicated in theory of mind processing and social emotions. Across subjects these cortical activities correlated positively with the difference between EX and FG in the percentage of trials where participants tossed the ball back to the same player (r = 0.69, p < 0.001). Together, the results suggested that, in healthy adults, social exclusion encumbered and engaged higher posterior cortical activations during self-initiated actions. The findings may facilitate future research of neural markers of social behavioral disorders.

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“…We analyzed a sample of 120 participants with FEP and 114 healthy participants (see Table 1 ). These analyses are a part of the Early Stages of SZ study ( 22 , 23 ). To ensure generalizability, we recruited participants during their first hospitalization in a large general psychiatry hospital (1,200 beds), which serves the Prague and part of Central Bohemia regions—catchment area of over 1.5 million subjects.…”

Section: Methodsmentioning

confidence: 99%

Higher Body-Mass Index and Lower Gray Matter Volumes in First Episode of Psychosis

et al. 2020

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Background Neurostructural alterations are often reported in first episode of psychosis (FEP), but there is heterogeneity in the direction and location of findings between individual studies. The reasons for this heterogeneity remain unknown. Obesity is disproportionately frequent already early in the course of psychosis and is associated with smaller brain volumes. Thus, we hypothesized that obesity may contribute to brain changes in FEP. Method We analyzed MRI scans from 120 participants with FEP and 114 healthy participants. In primary analyses, we performed voxel-based morphometry (VBM) with small volume corrections to regions associated with FEP or obesity in previous meta-analyses. In secondary analyses, we performed whole-brain VBM analyses. Results In primary analyses, we found that when controlling for BMI, FEP had lower GM volume than healthy participants in a) left fronto-temporal region (pTFCE = 0.008) and b) left postcentral gyrus (pTFCE = 0.043). When controlling for FEP, BMI was associated with lower GM volume in left cerebellum (pTFCE < 0.001). In secondary analyses, we found that when controlling for BMI, FEP had lower GM volume than healthy participants in the a) cerebellum (pTFCE = 0.004), b) left frontal (pTFCE = 0.024), and c) right temporal cortex (pTFCE = 0.031). When controlling for FEP, BMI was associated with lower GM volume in cerebellum (pTFCE = 0.004). Levels of C-reactive protein, HDL and LDL-cholesterol correlated with obesity related neurostructural alterations. Conclusions This study suggests that higher BMI, which is frequent in FEP, may contribute to cerebellar alterations in schizophrenia. As previous studies showed that obesity-related brain alterations may be reversible, our ﬁndings raise the possibility that improving the screening for and treatment of obesity and associated metabolic changes could preserve brain structure in FEP.

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Altered Neural Correlate of the Self-Agency Experience in First-Episode Schizophrenia-Spectrum Patients: An fMRI Study

Abstract: During self-agency experience, FES demonstrate deficit in engagement of cortical midline structures along with substantial attenuation of anti-correlated DMN/CEN activity underlying normal self/other-agency discriminative processes.

Cited by 31 publications

References 60 publications

Dysconnectivity of the Agency Network in Schizophrenia: A Functional Magnetic Resonance Imaging Study

Dysconnectivity of the Agency Network in Schizophrenia: A Functional Magnetic Resonance Imaging Study

Cerebral responses to self-initiated action during social interactions

Higher Body-Mass Index and Lower Gray Matter Volumes in First Episode of Psychosis

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