Altered Organelle Calcium Transport in Ovarian Physiology and Cancer

Caravia, Laura; Staicu, Cristina Elena; Radu, Beatrice Mihaela; Condrat, Carmen Elena; Crețoiu, Dragoș; Bacalbaşa, Nicolae; Suciu, Nicolae; Creţoiu, Sanda Maria; Voinea, S.

doi:10.3390/cancers12082232

Cited by 6 publications

(6 citation statements)

References 236 publications

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“…By contrast, Ca 2+ deficiency can halt cell cycle at the G 0 /G 1 and S phases (11). A number of ovarian pathologies, such as OC, typically result from the dysregulation of plasma membrane-based and organelle-based Ca 2+ signaling mechanisms (12). Ca 2+ levels have a profound effect on the physiology of the female reproductive system, especially the ovary.…”

Section: Calcium Signals and Potential Therapy Targets In Ovarian Can...mentioning

confidence: 99%

“…[Ca 2+ ]i concentrations can regulate almost every cellular process currently known, from energy production and cellular metabolism to phenotypic development. In particular, novel ideas of ovarian oncogenesis involving altered Ca 2+ signaling have been steadily proposed over the past decade (12). Variations in [Ca 2+ ]i concentrations can translate through the cell to effect distant regions, to modulate Ca 2+ signaling pathways that can regulate cell cycle progression, apoptosis, proliferation and metastasis.…”

Section: Calcium Signals and Potential Therapy Targets In Ovarian Can...mentioning

confidence: 99%

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Calcium signals and potential therapy targets in ovarian cancer (Review)

Deng,

Fu,

Zhao

et al. 2023

Int J Oncol

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Ovarian cancer (OC) is a deadly disease. The poor prognosis and high lethality of OC are attributed to its high degrees of aggressiveness, resistance to chemotherapy and recurrence rates. Calcium ion (Ca 2+ ) signaling has received attention in recent years, as it appears to form an essential part of various aspects of cancer pathophysiology and is a potential therapeutic target for OC treatment. Disruption of normal Ca 2+ signaling pathways can induce changes in cell cycle progression, apoptosis, proliferation and migration and invasion, leading to the development of the malignant phenotype of tumors. In the present review, the main roles of ion channel/receptor/pump-triggered Ca 2+ signaling pathways located at the plasma membrane and organelle Ca 2+ transport in OC are summarized. In addition, the potential of Ca 2+ signaling as a novel target for the development of effective treatment strategies for OC was discussed. Furthering the understanding into the role of Ca 2+ signaling in OC is expected to facilitated the identification of novel therapeutic targets and improved clinical outcomes for patients.

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Section: Calcium Signals and Potential Therapy Targets In Ovarian Can...mentioning

confidence: 99%

Section: Calcium Signals and Potential Therapy Targets In Ovarian Can...mentioning

confidence: 99%

Calcium signals and potential therapy targets in ovarian cancer (Review)

Deng,

Fu,

Zhao

et al. 2023

Int J Oncol

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Section: Calcium Retention Capacitymentioning

confidence: 99%

“…Calcium dysregulation can lead to a variety of diseases, including cancer [251][252][253][254]. In cancer, aberrant calcium signaling can enhance cell proliferation and angiogenesis [254,255]. Importantly, disruptions in calcium homeostasis are associated with increased apoptosis and autophagy in cancer cells [256,257], indicating that calcium dysregulation can produce effects on both ends of the spectrum.…”

Section: Calcium Retention Capacitymentioning

confidence: 99%

Methods to Evaluate Changes in Mitochondrial Structure and Function in Cancer

Rickard

Overchuk

Chappell

et al. 2023

Cancers

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Mitochondria are regulators of key cellular processes, including energy production and redox homeostasis. Mitochondrial dysfunction is associated with various human diseases, including cancer. Importantly, both structural and functional changes can alter mitochondrial function. Morphologic and quantifiable changes in mitochondria can affect their function and contribute to disease. Structural mitochondrial changes include alterations in cristae morphology, mitochondrial DNA integrity and quantity, and dynamics, such as fission and fusion. Functional parameters related to mitochondrial biology include the production of reactive oxygen species, bioenergetic capacity, calcium retention, and membrane potential. Although these parameters can occur independently of one another, changes in mitochondrial structure and function are often interrelated. Thus, evaluating changes in both mitochondrial structure and function is crucial to understanding the molecular events involved in disease onset and progression. This review focuses on the relationship between alterations in mitochondrial structure and function and cancer, with a particular emphasis on gynecologic malignancies. Selecting methods with tractable parameters may be critical to identifying and targeting mitochondria-related therapeutic options. Methods to measure changes in mitochondrial structure and function, with the associated benefits and limitations, are summarized.

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“…The T-type Ca 2+ channels, for example, are overexpressed in ovarian cancer where they are involved in tumor growth and its chemoresistance to platinum-based drugs [89]. Indeed, blocking T-type Ca 2+ channels with mibefradil during administration of carboplatin sensitizes platinum-resistant ovarian tumors to the anticancer drug-mediated toxicity [206]. Most studies reported in this review describe the implication of one channel in the regulation of OC development and progression.…”

Section: Concluding Remarks and Perspectivesmentioning

confidence: 99%

Emerging Roles for Ion Channels in Ovarian Cancer: Pathomechanisms and Pharmacological Treatment

Altamura

Greco

Carratù

et al. 2021

Cancers

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Ovarian cancer (OC) is the deadliest gynecologic cancer, due to late diagnosis, development of platinum resistance, and inadequate alternative therapy. It has been demonstrated that membrane ion channels play important roles in cancer processes, including cell proliferation, apoptosis, motility, and invasion. Here, we review the contribution of ion channels in the development and progression of OC, evaluating their potential in clinical management. Increased expression of voltage-gated and epithelial sodium channels has been detected in OC cells and tissues and shown to be involved in cancer proliferation and invasion. Potassium and calcium channels have been found to play a critical role in the control of cell cycle and in the resistance to apoptosis, promoting tumor growth and recurrence. Overexpression of chloride and transient receptor potential channels was found both in vitro and in vivo, supporting their contribution to OC. Furthermore, ion channels have been shown to influence the sensitivity of OC cells to neoplastic drugs, suggesting a critical role in chemotherapy resistance. The study of ion channels expression and function in OC can improve our understanding of pathophysiology and pave the way for identifying ion channels as potential targets for tumor diagnosis and treatment.

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Altered Organelle Calcium Transport in Ovarian Physiology and Cancer

Cited by 6 publications

References 236 publications

Calcium signals and potential therapy targets in ovarian cancer (Review)

Calcium signals and potential therapy targets in ovarian cancer (Review)

Methods to Evaluate Changes in Mitochondrial Structure and Function in Cancer

Emerging Roles for Ion Channels in Ovarian Cancer: Pathomechanisms and Pharmacological Treatment

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