Altered Penetration of Polyethylene Glycols into Uninvolved Skin of Atopic Dermatitis Patients

Jakaša, Ivone; Verberk, Maarten M.; Esposito, Maria; Bos, Jan D.; Kežić, Sanja

doi:10.1038/sj.jid.5700582

Cited by 113 publications

(82 citation statements)

References 32 publications

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“…Jakasa et al 74,75) showed approximately two times higher skin permeability to polyethylene glycols and a model skin irritant, sodium lauryl sulphate (SLS) in visually normal skin of AD patients as compared to controls. Consistently with these studies, de Jongh et al 46) reported an enhanced permeability to SLS in volunteers with ASD.…”

Section: Atopic Diathesis and Acdmentioning

confidence: 99%

Individual Susceptibility to Occupational Contact Dermatitis

2009

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Occupational Contact Dermatitis (OCD) is one of the most common work-related diseases. High risk occupations are in health care, hairdressing, food sector and metal industry. OCD tends to become chronic; persistent OCD often results in impaired quality of life and loss of work ability. The purpose of this article is to review the present knowledge on the factors which determine individual susceptibility to acquire OCD. Recent discoveries regarding genes involved in the skin barrier, inflammatory response and biotransformation of xenobiotics provide more insight in the individual susceptibility for OCD. Knowledge of the factors which predispose to OCD is useful in occupational health practice for the application of preventive measures and for career guidance for apprentices and workers in high risk occupations.

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Section: Atopic Diathesis and Acdmentioning

confidence: 99%

Individual Susceptibility to Occupational Contact Dermatitis

2009

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“…In order to obtain more data to assess the barrier function of uninvolved skin in atopic dermatitis (AD) patients, Jakasa et al [86] determined the percutaneous penetration of PEGs of various molecular sizes in vivo in AD patients and control subjects using TS of the SC. The apparent diffusion coefficient of PEGs through atopic skin was twice as high as through normal skin, and decreased with increasing MW in both groups.…”

Section: Other Kind Of Permeants (Polyethylene Glycols 4-cyanophenol)mentioning

confidence: 99%

The Tape-Stripping Technique as a Method for Drug Quantification in Skin

Merino-Sanjuán²,

et al. 2008

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-Quantification of drugs within the skin is essential for topical and transdermal delivery research. Over the last two decades, horizontal sectioning, consisting of tape stripping throughout the stratum corneum, has become one of the traditional investigative techniques.Tape stripping of human stratum corneum is widely used as a method for studying the kinetics and penetration depth of drugs. This paper shows the applications of the tape stripping technique to quantify drug penetration through the skin, underlining its versatile application in the area of topical and transdermal drugs.

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“…4) Despite many percutaneously applied cosmetics and drugs being used to treat damaged skin or diseases that affect skin condition, few reports have shown a difference in penetration and permeation between normal and damaged skin. [5][6][7] Advanced glycation end products (AGEs), which are linked to both aging and hyperglycemia, cause marked functional and structural alterations in human skin. 8,9) AGEs are generated via the non-enzymatic Maillard reaction between reducing sugars and proteins, lipids or nucleic acids.…”

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confidence: 99%

Permeation of Hydrophilic Molecules across Glycated Skin Is Differentially Regulated by the Stratum Corneum and Epidermis–Dermis

Yokota

Tokudome

2015

Biological & Pharmaceutical Bulletin

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The effects of glycation on skin permeation and accumulation of compounds were evaluated using an in vitro glycated skin model. Glycation of the skin of hairless mice was induced using vertical diffusion cells and incubation with phosphate-buffered saline containing 50 mM glyoxal for 24 h. Flux and accumulation in the skin were determined by applying hydrophilic and lipophilic molecules (Sodium fluorescein; FL-Na and Nile red, respectively) to this in vitro glycated skin model. Furthermore, to investigate the effect of glycation on epidermal-dermal barrier properties, we conducted diffusion experiments with FL-Na and fluorescein isothiocyanate-dextran using stratum corneum (SC)-stripped glycated skin. The in vitro glycated skin model demonstrated characteristic glycation alterations like a yellowish change in skin color and surface roughness. For low-molecular weight (MW) hydrophilic molecules, flux across glycated full-thickness skin was higher than that across normal skin, although there was no difference with lipophilic molecules. However, glycated epidermis-dermis showed lower flux, and the difference increased with the MW of the compound. Furthermore, the amount of high-MW hydrophilic molecules accumulated in glycated epidermis-dermis was decreased. These results suggest that glycated SC and epidermis-dermis differentially regulate the permeability of hydrophilic molecules and highlight the importance of controlling drug delivery by modifying the formulation or method of application depending on skin condition. Key words skin permeation; advanced glycation end product; stratum corneum As a route of drug administration, the skin attracts much attention due to non-invasive application, ease of dose control and absorption without hepatic first-pass metabolism. However, human skin changes over time due to chronological aging, exposure to UV radiation, and diseases such as atopic dermatitis and psoriasis. With the increase in the aging population in recent decades, there is a growing need to care for a variety of skin types. Therapeutic applications involving the skin have also increased in diversity in recent years. A variety of chemical and physiological methods are being studied to lower the barrier posed by the skin's outermost layer, the stratum corneum (SC).1) Consisting of corneocytes and intercellular lipids, the SC plays an important role as a rate limiting layer for the penetration of compounds. Serving as the major protection from foreign chemicals and water loss, and also associated with body temperature regulation, the SC is permeable to only lipophilic and <500 Da compounds.2) Therefore, various biochemical approaches to increase permeability across the SC have been attempted over the years.3) Physical methods such as microneedles, thermal ablation and microdermabrasion are also used to enhance the efficiency of penetration by piercing or removing the SC. Additionally, iontophoresis and sonophoresis increase skin permeability by electrical driving force and ultrasound, respectively. 4)Despite many ...

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Altered Penetration of Polyethylene Glycols into Uninvolved Skin of Atopic Dermatitis Patients

Cited by 113 publications

References 32 publications

Individual Susceptibility to Occupational Contact Dermatitis

Individual Susceptibility to Occupational Contact Dermatitis

The Tape-Stripping Technique as a Method for Drug Quantification in Skin

Permeation of Hydrophilic Molecules across Glycated Skin Is Differentially Regulated by the Stratum Corneum and Epidermis–Dermis

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