Altered plasma levels of lysophospholipids in response to adrenalectomy of rats

Lysophosphatidylserine: A Signaling Lipid with Implications in Human Diseases

“…Different studies that report the quantitative profiling of lyso-PS in various rodent tissues have shown that this signaling lysophospholipid is present in the central nervous system (brain, spinal cord, eye), 90,92,95 metabolic tissues (liver, kidney, heart, lungs, colon), 90,93 tissues of the immune system (spleen, thymus, lymph node), 93 and plasma/serum. 44,96 Of these tissues in mice, the anatomical distribution of lyso-PS has extensively been studied in the brain, and even though it is ubiquitously present throughout this tissue of the central nervous system, it is significantly enriched in the cerebellum and the olfactory bulb. 90,92,95 Studies from cultured mammalian cells have shown that lyso-PS is present in both the cells and secreted media of various primary immune cells (e.g., macrophages, mast cells, microglia, T cells) and several immortalized cell lines (e.g., cancer cell lines, macrophage cell lines, lymphoblast cell lines from human subjects).…”

“…Using the lipid extraction and LCMS protocols discussed in section , quite some knowledge is now available for the distribution of lyso-PS lipids in various mammalian systems, largely from screening of tissues from rodent models (mostly mice) and cell lines. Different studies that report the quantitative profiling of lyso-PS in various rodent tissues have shown that this signaling lysophospholipid is present in the central nervous system (brain, spinal cord, eye), ,, metabolic tissues (liver, kidney, heart, lungs, colon), , tissues of the immune system (spleen, thymus, lymph node), and plasma/serum. , Of these tissues in mice, the anatomical distribution of lyso-PS has extensively been studied in the brain, and even though it is ubiquitously present throughout this tissue of the central nervous system, it is significantly enriched in the cerebellum and the olfactory bulb. ,, Studies from cultured mammalian cells have shown that lyso-PS is present in both the cells and secreted media of various primary immune cells (e.g., macrophages, mast cells, microglia, T cells) and several immortalized cell lines (e.g., cancer cell lines, macrophage cell lines, lymphoblast cell lines from human subjects). ,,− Among the rodent tissues and various cell lines profiled, C18:0 and C18:1 lyso-PSs seem to be the most abundant species, with C16:0, C20:4, and C22:6 being the other consistently detectable lyso-PS species in these mammalian biological systems. There are currently no extensive tissue-wide lyso-PS profiling studies available in humans.…”