Altered Plasma Proteins in Myogenous Temporomandibular Disorders

Ernberg, Malin; Jasim, Hajer; Wåhlén, Karin; Ghafouri, Bijar

doi:10.3390/jcm11102777

Cited by 2 publications

(1 citation statement)

References 63 publications

(76 reference statements)

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“…Such studies may reveal the biological underpinnings of this common and severe disorder that are unknown to date and can subsequently be investigated in directed, experimental studies. Most pain studies using this approach have been cross-sectional, comparing defined pain populations with healthy controls, assuming that the differences between groups reflect a specific pattern in the chosen biological fluid related to that particular pain disorder [ 24 , 25 , 26 , 27 , 28 , 29 , 30 , 31 , 32 , 33 ]. The focus is usually on pain intensity, as pain research ultimately aims to eradicate the pain [ 34 , 35 , 36 , 37 , 38 ].…”

Section: Introductionmentioning

confidence: 99%

Inflammatory Blood Signature Related to Common Psychological Comorbidity in Chronic Pain

et al. 2023

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Chronic pain is characterized by high psychological comorbidity, and diagnoses are symptom-based due to a lack of clear pathophysiological factors and valid biomarkers. We investigate if inflammatory blood biomarker signatures are associated with pain intensity and psychological comorbidity in a mixed chronic pain population. Eighty-one patients (72% women) with chronic pain (>6 months) were included. Patient reported outcomes were collected, and blood was analyzed with the Proseek Multiplex Olink Inflammation Panel (Bioscience Uppsala, Uppsala, Sweden), resulting in 77 inflammatory markers included for multivariate data analysis. Three subgroups of chronic pain patients were identified using an unsupervised principal component analysis. No difference between the subgroups was seen in pain intensity, but differences were seen in mental health and inflammatory profiles. Ten inflammatory proteins were significantly associated with anxiety and depression (using the Generalized Anxiety Disorder 7-item scale (GAD-7) and the Patient Health Questionnaire (PHQ-9): STAMBP, SIRT2, AXIN1, CASP-8, ADA, IL-7, CD40, CXCL1, CXCL5, and CD244. No markers were related to pain intensity. Fifteen proteins could differentiate between patients with moderate/high (GAD-7/PHQ-9 > 10) or mild/no (GAD-7/PHQ-9 < 10) psychological comorbidity. This study further contributes to the increasing knowledge of the importance of inflammation in chronic pain conditions and indicates that specific inflammatory proteins may be related to psychological comorbidity.

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Section: Introductionmentioning

confidence: 99%

Inflammatory Blood Signature Related to Common Psychological Comorbidity in Chronic Pain

et al. 2023

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Oral behaviors in Chinese temporomandibular disorder patients: insights from exploratory and confirmatory factor analyses

Liu,

Yap,

Sun

et al. 2024

Front. Neurol.

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AimThis study aimed to evaluate the factor structure of the Oral Behaviors Checklist (OBC) in Chinese temporomandibular disorder (TMDs) patients and compare the outcomes with those of Western patients. Additionally, it examined the correlations between different OBC subscale scoring methods.MethodsA total of 869 patients completed a survey that included demographic information, the Symptom Questionnaire, and OBC. This was followed by a clinical examination and diagnosis based on the Diagnostic Criteria for TMDs (DC/TMDs). Exploratory factor analysis, along with confirmatory factor analysis, was applied to waking-state oral behaviors, revealing two key factors: Chinese non-functional (C-NFA) and functional (C-FA) oral activities. Items were contrasted with those of Italian TMDs patients (I-NFA and I-FA), and subscale scores were computed, compared, and correlated using Kruskal Wallis and Post-hoc and Spearman’s rank-order correlation (α = 0.05).ResultsVariations in NFA and FA items were observed between Chinese and Italian TMDs patients. For both NFA scoring methods, significant differences were noted between pain-related and intra-articular TMDs. The C-NFA and I-NFA, as well as C-FA and I-FA, scoring methods yielded scores with strong correlations (r > 0.8).ConclusionNFA and FA subscale items were determined for Chinese TMDs patients. Despite item discrepancies, C-NFA and C-FA scores were strongly correlated with I-NFA and I-FA scores, respectively. The OBC can be effectively simplified for use with Chinese TMDs patients. Developing and validating an East–West short-form version of the OBC should be prioritized, given the variations in oral behaviors across countries and cultures.

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Altered Plasma Proteins in Myogenous Temporomandibular Disorders

Cited by 2 publications

References 63 publications

Inflammatory Blood Signature Related to Common Psychological Comorbidity in Chronic Pain

Inflammatory Blood Signature Related to Common Psychological Comorbidity in Chronic Pain

Oral behaviors in Chinese temporomandibular disorder patients: insights from exploratory and confirmatory factor analyses

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