2017
DOI: 10.1016/j.bbi.2017.06.011
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Altered populations of natural killer cells, cytotoxic T lymphocytes, and regulatory T cells in major depressive disorder: Association with sleep disturbance

Abstract: A subset of individuals with major depressive disorder (MDD) have impaired adaptive immunity characterized by a greater vulnerability to viral infection and a deficient response to vaccination along with a decrease in the number and/or activity of T cells and natural killer cells (NKC). Nevertheless, it remains unclear which specific subsets of lymphocytes are altered in MDD, a shortcoming we address here by utilizing an advanced fluorescence-activated cell sorting (FACS) method that allows for the differentia… Show more

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Cited by 77 publications
(62 citation statements)
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“…Whether the epigenetic remodeler complex HDAC3-NCoR-RevErbα regulates VDJ recombination should be addressed to find out the possibility of a direct link with the clock machinery in this crucial element of the adaptive immunity. Finally, sleep disturbance appears to be related with a reduction in NK cells, and sleep modulates immunological memory in humans (Geiger et al, 2015;Suzuki et al, 2017), while in Drosophila the gene nemuri is a neuronal antimicrobial peptide that also promotes sleep (Toda et al, 2019). All together, these findings reinforce the notion that the circadian clock is necessary to the induction of appropriate adaptive immune responses.…”
Section: The Adaptive Immune System and The Circadian Clock: An Epigementioning
confidence: 58%
“…Whether the epigenetic remodeler complex HDAC3-NCoR-RevErbα regulates VDJ recombination should be addressed to find out the possibility of a direct link with the clock machinery in this crucial element of the adaptive immunity. Finally, sleep disturbance appears to be related with a reduction in NK cells, and sleep modulates immunological memory in humans (Geiger et al, 2015;Suzuki et al, 2017), while in Drosophila the gene nemuri is a neuronal antimicrobial peptide that also promotes sleep (Toda et al, 2019). All together, these findings reinforce the notion that the circadian clock is necessary to the induction of appropriate adaptive immune responses.…”
Section: The Adaptive Immune System and The Circadian Clock: An Epigementioning
confidence: 58%
“…However, recent studies have identified regulatory roles in T‐cell responses and homeostasis. Dysfunction of these regulatory roles has been linked to MS, and reduced levels of NK cells have been found in depression . Mast cells mediate BBB permeability and recruitment of immune cells into the brain, sustaining CNS inflammation in a potentially detrimental manner .…”
Section: Innate Immunitymentioning
confidence: 99%
“…Blood proteins, such as cytokines and CRP, have been the focus of most immune biomarker research in psychiatry to SEE COMMENTARY ON date; the potential utility of cellular immune markers has been relatively underexplored (12)(13)(14)(15)(16)(17)(18). Most case-control studies of leukocyte subsets have used small samples and limited immunophenotyping panels and have generated inconsistent results.…”
mentioning
confidence: 99%
“…Depression has been reproducibly associated with leukocytosis, increased neutrophil-to-lymphocyte ratio, and increased ratio of CD4 1 to CD8 1 T cells (19)(20)(21). However, there are less consistent results concerning regulatory T cells, T-helper 17 cells, natural killer (NK) cells, monocytes, and B cells (12)(13)(14)(15)(16)18,22). Other psychiatric disorders, including schizophrenia, bipolar disorder, and autism, have also been associated with altered cell counts (23)(24)(25).…”
mentioning
confidence: 99%