Altered profiles of intestinal microbiota and organic acids may be the origin of symptoms in irritable bowel syndrome

Tana, Chie; Umesaki, Yoshinori; Imaoka, Akemi; Handa, Tomoyuki; Kanazawa, Motoyori; Fukudo, Shin

doi:10.1111/j.1365-2982.2009.01427.x

Cited by 318 publications

(363 citation statements)

References 48 publications

(83 reference statements)

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“…An initial study that suggested the role of H 2 in IBS analysed the total excretion of colonic gas in six IBS patients, who showed elevated production of H 2 on a fibrerich diet, although the total volume of gas did not differ when compared with the HCs (King et al, 1998). Similarly, Tana et al (2010) found no difference in the amount of Xray-quantified colonic gas between the IBS patients and the HCs. Recently, Serra et al (2010) demonstrated that IBS patients have sensory dysfunction and poor tolerance to moderate gas loads, in line with the hypothesis that the IBS symptoms arise more from the visceral hypersensitivity than from the elevated amount of intestinal gas.…”

Section: Functional Perspective On Ibs-related Microbiotamentioning

confidence: 88%

“…A significant increase of bacterially produced short chain fatty acids (SCFAs) was recently recorded in the faeces of Japanese IBS patients who also harboured significantly more lactobacilli and Veillonella spp. compared with HCs (Tana et al, 2010). The increase in total SCFAs was due to the increase of acetic and propionic, but not butyric, acid.…”

Section: Functional Perspective On Ibs-related Microbiotamentioning

confidence: 88%

“…Acetate is a known chemical irritant, and at high concentrations is used to induce mucosal lesions and abdominal cramps in experimental animals, while butyrate is considered as protective and able to dose-dependently reduce abdominal pain in humans in vivo (Vanhoutvin et al, 2009). While IBS patients as a single group differed significantly from the HCs with respect to organic acids and microbiota, none of the three subtypes alone showed a significant difference in these aspects (Tana et al, 2010). Similarly, in the study of Malinen et al (2005), all IBS subgroups had elevated levels of Veillonella spp., C. coccoides and R. productus, all able to produce acetate and succinate (Liu et al, 2008).…”

Section: Functional Perspective On Ibs-related Microbiotamentioning

confidence: 88%

“…A decrease of lactobacilli has been detected in IBS-D (Malinen et al, 2005;Krogius-Kurikka et al, 2009) and IBS-A patients (Kerckhoffs et al, 2009). On the other hand, untypically high faecal amounts of lactobacilli and/or streptococci have been reported for IBS-D patients (Kassinen et al, 2007;Krogius-Kurikka et al, 2009;Carroll et al, 2008) as well as IBS patients independent of the subtype (Tana et al, 2010). This trend suggests that at least some IBS patients, similarly to ileostomy patients, have an outgrowth of aerobic bacteria that may be linked to the overproduction of organic acids, as will be discussed below.…”

Section: Microbiota In Different Ibs Subtypesmentioning

confidence: 99%

“…The GI microbiota of IBS-D patients seems to deviate the most and that of IBS-C patients the least from that of HCs Rajilić-Stojanović, 2007). Most of the observed differences could be assigned to the Firmicutes, as they dominate the significant alterations in the comparison of clone libraries (Kassinen et al, 2007;Krogius-Kurikka et al, 2009), microarray-derived microbiota profiles (Rajilić-Stojanović, 2007) and qPCR assays Malinen et al, 2005;Tana et al, 2010) between IBS patients and HCs. More specifically, the genera Streptococcus, Lactobacillus and Veillonella, as well as members of the families Lachnospiraceae and Ruminococcaceae, stand out from the comparisons, although with a somewhat inconsistent association with IBS status.…”

Section: Microbiota In Different Ibs Subtypesmentioning

confidence: 99%

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Gastrointestinal microbiota in irritable bowel syndrome: present state and perspectives

2010

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Irritable bowel syndrome (IBS) is a functional gastrointestinal disorder that has been associated with aberrant microbiota. This review focuses on the recent molecular insights generated by analysing the intestinal microbiota in subjects suffering from IBS. Special emphasis is given to studies that compare and contrast the microbiota of healthy subjects with that of IBS patients classified into different subgroups based on their predominant bowel pattern as defined by the Rome criteria. The current data available from a limited number of patients do not reveal pronounced and reproducible IBS-related deviations of entire phylogenetic or functional microbial groups, but rather support the concept that IBS patients have alterations in the proportions of commensals with interrelated changes in the metabolic output and overall microbial ecology. The lack of apparent similarities in the taxonomy of microbiota in IBS patients may partially arise from the fact that the applied molecular methods, the nature and location of IBS subjects, and the statistical power of the studies have varied considerably. Most recent advances, especially the finding that several uncharacterized phylotypes show non-random segregation between healthy and IBS subjects, indicate the possibility of discovering bacteria specific for IBS. Moreover, tools are being developed for the functional analysis of the relationship between the intestinal microbiota and IBS. These approaches may be instrumental in the evaluation of the ecological dysbiosis hypothesis in the gut ecosystem. Finally, we discuss the future outlook for research avenues and candidate microbial biomarkers that may eventually be used in IBS diagnosis. IntroductionWe are colonized from birth by a complex microbiota that affects health and disease. By far the greater part of this microbiota resides in the gastrointestinal (GI) tract, and can be considered as an organ within an organ (Bocci, 1992). As many of the GI tract microbes have not yet been cultured and are only recognized based on their 16S rDNA sequences, molecular high-throughput approaches have been developed to study the diversity and functionality of the thousands of phylotypes that have been predicted to be present in the GI tract (for a full review, see Zoetendal et al., 2008). These studies have revealed that the composition of the microbiota in healthy adults is highly subject-specific and stable, indicating an individual core. Comparative microbiota analyses between multiple healthy subjects indicate that a limited proportion of phylotypes are shared between individuals, forming a common core microbiota that is assumed to be functionally redundant (Qin et al., 2010;Tap et al., 2009;Turnbaugh et al., 2009). Recent metagenomic sequence analysis of the GI tract microbiota has confirmed this and defined a reference set of over three million unique genes that vastly exceeds the coding capacity of the human genome (Qin et al., 2010). Insight into the microbiota of healthy subjects allows comparisons with that of compromised...

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Section: Functional Perspective On Ibs-related Microbiotamentioning

confidence: 88%

Section: Functional Perspective On Ibs-related Microbiotamentioning

confidence: 88%

Section: Functional Perspective On Ibs-related Microbiotamentioning

confidence: 88%

Section: Microbiota In Different Ibs Subtypesmentioning

confidence: 99%

Section: Microbiota In Different Ibs Subtypesmentioning

confidence: 99%

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Gastrointestinal microbiota in irritable bowel syndrome: present state and perspectives

2010

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Cross‐Cohort Gut Microbiome Signatures of Irritable Bowel Syndrome Presentation and Treatment

Li,

Ghosh,

Arendt

et al. 2024

Advanced Science

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Irritable bowel syndrome (IBS) is a prevalent disorder of gut‐brain interaction without a reliable cure. Evidence suggests that an alteration of the gut microbiome may contribute to IBS pathogenesis, motivating the development of microbiome‐targeted therapies to alleviate IBS symptoms. However, IBS‐specific microbiome signatures are variable across cohorts. A total of 9204 datasets were meta‐analyzed, derived from fourteen IBS microbiome discovery cohorts, three validation cohorts for diet‐microbiome interactions, and five rifaximin therapy cohorts. The consistent bacterial species and functional signatures associated with IBS were identified. Network analysis revealed two distinct IBS‐enriched microbiota clusters; obligate anaerobes that are found commonly in the gut, and facultative anaerobes typically present in the mouth, implying a possible association between oral bacterial translocation to gut and IBS pathogenesis. By analyzing diet‐microbiome interactions, microbiota‐targeted diets that can potentially modulate the altered gut microbiota of IBS subjects toward a healthy status were identified. Furthermore, rifaximin treatment of IBS subjects was linked with a reduction in the abundance of facultatively anaerobic pathobionts. Gut microbiome signatures were identified across IBS cohorts that may inform the development of therapies for microbiome modulation in IBS. The microbiota‐targeted diet patterns described may enable nutritional intervention trials in IBS and for assisting dietary management.

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The role of the brain–gut–microbiota axis in psychology: The importance of considering gut microbiota in the development, perpetuation, and treatment of psychological disorders

Ganci

Suleyman

Butt³

et al. 2019

Brain and Behavior

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IntroductionThe prevalence of psychological disorders remains stable despite steady increases in pharmacological treatments suggesting the need for auxiliary treatment options. Consideration of the brain–gut–microbiota axis (BGMA) has made inroads into reconceptualizing psychological illness from a more holistic perspective. While our understanding of the precise role of gut microbiota (GM) in psychological illness is in its infancy, it represents an attractive target for novel interventions.MethodAn extensive review of relevant literature was undertaken.ResultsGut microbiota are proposed to directly and indirectly influence mood, cognition, and behavior which are key components of mental health. This paper outlines how GM may be implicated in psychological disorders from etiology through to treatment and prevention using the Four P model of case formulation.ConclusionMoving forward, integration of GM into the conceptualization and treatment of psychological illness will require the discipline of psychology to undergo a significant paradigm shift. While the importance of the GM in psychological well‐being must be respected, it is not proposed to be a panacea, but instead, an additional arm to a multidisciplinary approach to treatment and prevention.

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Altered profiles of intestinal microbiota and organic acids may be the origin of symptoms in irritable bowel syndrome

Cited by 318 publications

References 48 publications

Gastrointestinal microbiota in irritable bowel syndrome: present state and perspectives

Gastrointestinal microbiota in irritable bowel syndrome: present state and perspectives

Cross‐Cohort Gut Microbiome Signatures of Irritable Bowel Syndrome Presentation and Treatment

The role of the brain–gut–microbiota axis in psychology: The importance of considering gut microbiota in the development, perpetuation, and treatment of psychological disorders

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