Altered Quality of Life and Psychological Health (SCL-90-R) in Patients With Chronic Rhinosinusitis With Nasal Polyps

Chung, Jae Ho; Lee, Yun Jae; Kang, Tae Wook; Kim, Kyung Rae; Jang, Dong Pyo; Kim, In Young; Cho, Seok Hyun

doi:10.1177/0003489415576181

Cited by 43 publications

(41 citation statements)

References 25 publications

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“…Two studies did not find any association between age and olfactory dysfunction . Within CRS‐specific factors, a higher Lund‐Mackay (LM) computed tomography (CT) score was most frequently associated with poorer smell with 11 studies reporting this relationship . Remaining studies did not examine this association.…”

Section: Resultsmentioning

confidence: 98%

“…Six studies in CRS mixed and two studies in CRSwNP presented standard 16‐odor identification scores, yielding a population of 899 and 187 patients, respectively. Olfactory dysfunction using the 16‐odor Sniffin' Sticks identification test is defined as scores ≤11 .…”

Section: Resultsmentioning

confidence: 99%

“…The combined prevalence of normosmics, hyposmics, anosmics, and overall olfactory dysfunction was 6.32% (I 2 5 96.81%; random), 33.20% (I 2 5 97.06%; random), 56.81% (I 2 5 98.64%; random), and 93.68% (I 2 5 96.81%; random), respectively (Table I). Four studies in CRSwNP [18][19][20][21] presented TDI total scores, yielding a population of 233 patients. Pooled TDI score was 15.58 6 6.49, which falls into hyposmic range.…”

Section: Search Characteristicsmentioning

confidence: 99%

“…SNIFFIN' STICKS-THRESH-OLD. Six studies in CRS mixed 12,14,16,[53][54][55] and two studies in CRSwNP 18,19 presented threshold scores, yielding a population of 386 and 187 patients, respectively. Olfactory dysfunction using the Sniffin' Sticks threshold tests is defined as 6.00 in males and 6.50 in females.…”

Section: -Item Smell Identifi-cation Test Four Studies In Crs Mixedmentioning

confidence: 99%

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The prevalence of olfactory dysfunction in chronic rhinosinusitis

et al. 2016

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Objective Many studies have reported that olfactory dysfunction frequently occurs in chronic rhinosinusitis (CRS) populations; however, the prevalence and degree of olfactory loss has not been systematically studied. The aims of this study are to use combined data to report the prevalence of olfactory dysfunction and to calculate weighted averages of olfactory test scores in CRS patients. Data Sources A search was conducted in PubMed and Scopus, following the methods of Preferred Reporting Items for Systematic Review and Meta-Analysis guidelines. Review Methods Studies reporting the prevalence of olfactory dysfunction using objective measures or olfactory test scores using validated scales were included. Results A total of 47 articles were included in systematic review and 35 in the pooled data analysis. The prevalence of olfactory dysfunction in chronic rhinosinusitis was found to be 30.0% using the Brief Smell Identification Test, 67.0% using the 40-item Smell Identification Test, and 78.2% using the total Sniffin’ Sticks score. Weighted averages ± standard deviation of olfactory test scores were 25.96±7.11 using the 40-item Smell Identification Test, 8.60±2.81 using the Brief Smell Identification Test, 21.96±8.88 using total Sniffin’ sticks score, 5.65±1.51 using Sniffin’ Sticks threshold, 9.21±4.63 using Sniffin’ Sticks discrimination, 9.47±3.92 using Sniffin’ Sticks Identification, and 8.90±5.14 using the questionnaire for olfactory disorders-negative statements. Conclusion In chronic rhinosinusitis populations, a significant percentage of patients experience olfactory dysfunction and mean olfactory scores are within the dysosmic range.

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Section: Resultsmentioning

confidence: 98%

Section: Resultsmentioning

confidence: 99%

Section: Search Characteristicsmentioning

confidence: 99%

Section: -Item Smell Identifi-cation Test Four Studies In Crs Mixedmentioning

confidence: 99%

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The prevalence of olfactory dysfunction in chronic rhinosinusitis

et al. 2016

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“…Three studies examined baseline medication usage, productivity, or physician visits, and found that comorbid depression was uniformly associated with worse performance across each of these metrics (Table 2). 7,9,17 Two studies 19,21 reported worse baseline olfaction in patients with CRS and depression, although one of these studies was limited to patients with CRS with nasal polyposis. 21 …”

Section: Factors Associated With a Positive Depression Screen Results mentioning

confidence: 99%

Burden of Illness: A Systematic Review of Depression in Chronic Rhinosinusitis

Schlosser

Gage

Kohli

et al. 2016

Am J Rhinol�Allergy

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A systematic review to examine the relationship between objective and patient‐reported outcome measures in sinonasal disorders: recommendations for use in research and clinical practice

Philpott

2021

Int Forum Allergy Rhinol

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Background Common sinonasal disorders include chronic rhinosinusitis (CRS), allergic rhinitis (AR), and a deviated nasal septum (DNS), which often coexist with shared common symptoms including nasal obstruction, olfactory dysfunction, and rhinorrhea. Various objective outcome measures and patient‐reported outcome measures (PROMs) are used to assess disease severity; however, there is limited evidence in the literature on the correlation between them. This systematic review aims to examine the relationship between them and provide recommendations. Methods A search of MEDLINE and EMBASE identified studies quantifying correlations between objective outcome measures and PROMs for the sinonasal conditions using a narrative synthesis. Results In total, 59 studies met inclusion criteria. For nasal obstruction, rhinomanometry shows a lack of correlation whereas peak nasal inspiratory flow (PNIF) shows the strongest correlation with PROMs (r > 0.5). The Sniffin’ Stick test shows a stronger correlation with PROMs (r > 0.5) than the University of Pennsylvania Smell Identification Test (UPSIT) (r < 0.5). Computed tomography (CT) sinus scores show little evidence of correlation with PROMs and nasal endoscopic ratings (weak correlation, r < 0.5). Conclusion Overall, objective outcome measures and PROMs assessing sinonasal symptoms are poorly correlated, and we recommend that objective outcome measures be used with validated PROMs depending on the setting. PNIF should be used in routine clinical practice for nasal obstruction; rhinomanometry and acoustic rhinometry may be useful in research. The Sniffin’ Sticks test is recommended for olfactory dysfunction with UPSIT as an alternative. CT scores should be excluded as a routine CRS outcome measure, and endoscopic scores should be used in combination with PROMs until further research is conducted.

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Altered Quality of Life and Psychological Health (SCL-90-R) in Patients With Chronic Rhinosinusitis With Nasal Polyps

Abstract: Olfactory dysfunction may have significant effects on QOL and psychological health. CRSwNP with anosmia is a distinct phenotype having mixed type of olfactory loss that might have a detrimental effect on depression.

Cited by 43 publications

References 25 publications

The prevalence of olfactory dysfunction in chronic rhinosinusitis

The prevalence of olfactory dysfunction in chronic rhinosinusitis

Burden of Illness: A Systematic Review of Depression in Chronic Rhinosinusitis

A systematic review to examine the relationship between objective and patient‐reported outcome measures in sinonasal disorders: recommendations for use in research and clinical practice

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