Altered radiation fractionation schedules for clinically localised and locally advanced prostate cancer

Soh, Feng-Yi; James, Melissa; Hickey, Brigid E; Daly, Tiffany; Jeffery, Mark; See, Adrienne M; Francis, Daniel

doi:10.1002/14651858.cd011462

Cochrane Database of Systematic Reviews

2015

DOI: 10.1002/14651858.cd011462

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Altered radiation fractionation schedules for clinically localised and locally advanced prostate cancer

Feng-Yi Soh

Melissa James

Brigid E Hickey

et al.

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Cited by 4 publications

(1 citation statement)

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“…In addition, many current trial protocols for modified fractionation and comparative reviews of the efficacy of different radiotherapy schedules, now use BED and associated parameter values like EQD2 (EQuivalent Dose in 2 Gy fractions) to predict, describe, or compare outcomes [e.g. 15 ], and Jack made a big contribution to the use of those quantitative measures. He will be remembered not only for his many pertinent contributions and by the several generations of people who worked with him and/or learnt from him, but also by the ESTRO "Jack Fowler University of Wisconsin Award to honour an outstanding junior investigator", and the Radiation Research Society "Jack Fowler Award, provided by the University of Wisconsin to honour the achievements of Professor Jack Fowler.…”

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confidence: 99%

Commemoration of Jack Fowler’s life, work, impact and legacy

Hendry

2018

The British Journal of Radiology

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Jack Fowler [formally Professor John Francis Fowler PhD, DSc, MD (Hon), FInstP, FRCR, FBIR, FAAPM, FASTRO, FACRO] was a remarkable scientist, known to many in the field of clinical radiation biology as at the forefront of applying linear-quadratic dose-fractionation-time modelling to help improve a wide range of cancer treatments using radiotherapy. His death on 1st December 2016 after a long career of 60 years was marked by Obituaries in six scientific journals in his field e.g. Jack is remembered for his quantification of biologically effective dose in a wide variety of radiotherapy practices and modified protocols (supported by experimental-system studies), his extensive publications, his didactic lecturing and teaching abilities, and his warm personality.

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mentioning

confidence: 99%

Commemoration of Jack Fowler’s life, work, impact and legacy

Hendry

2018

The British Journal of Radiology

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Hypofractionation for clinically localized prostate cancer

Hickey

James

Daly

et al. 2019

Cochrane Database of Systematic Reviews

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Background Using hypofractionation (fewer, larger doses of daily radiation) to treat localized prostate cancer may improve convenience and resource use. For hypofractionation to be feasible, it must be at least as effective for cancer-related outcomes and have comparable toxicity and quality of life outcomes as conventionally fractionated radiation therapy. Objectives To assess the effects of hypofractionated external beam radiation therapy compared to conventionally fractionated external beam radiation therapy for men with clinically localized prostate cancer. Search methods We searched CENTRAL, MEDLINE (Ovid), Embase (Ovid) and trials registries from 1946 to 15 March 2019 with reference checking, citation searching and contact with study authors. Searches were not limited by language or publication status. We reran all searches within three months (15th March 2019) prior to publication. Selection criteria Randomized controlled comparisons which included men with clinically localized prostate adenocarcinoma where hypofractionated radiation therapy (external beam radiation therapy) to the prostate using hypofractionation (greater than 2 Gy per fraction) compared with conventionally fractionated radiation therapy to the prostate delivered using standard fractionation (1.8 Gy to 2 Gy per fraction). Data collection and analysis We used standard Cochrane methodology. Two authors independently assessed trial quality and extracted data. We used Review Manager 5 for data analysis and meta-analysis. We used the inverse variance method and random-effects model for data synthesis of time-to-event data with hazard ratios (HR) and 95% confidence intervals (CI) reported. For dichotomous data, we used the Mantel-Haenzel method and random-effects model to present risk ratios (RR) and 95% CI. We used GRADE to assess evidence quality for each outcome. Main results We included 10 studies with 8278 men in our analysis comparing hypofractionation with conventional fractionation to treat prostate cancer. Primary outcomes Hypofractionation for clinically localized prostate cancer (Review)

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Interventions to reduce acute and late adverse gastrointestinal effects of pelvic radiotherapy

Lawrie

Green

Beresford

et al. 2017

Cochrane Database of Systematic Reviews

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Altered radiation fractionation schedules for clinically localised and locally advanced prostate cancer

Cited by 4 publications

References 40 publications

Commemoration of Jack Fowler’s life, work, impact and legacy

Commemoration of Jack Fowler’s life, work, impact and legacy

Hypofractionation for clinically localized prostate cancer

Interventions to reduce acute and late adverse gastrointestinal effects of pelvic radiotherapy

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