Altered response in cutaneous sympathetic outflow to mental and thermal stimuli in primary palmoplantar hyperhidrosis

Iwase, Satoshi; Ikeda, Takehiko; Kitazawa, Hiroki; Hakusui, Shigetaka; Sugenoya, Junichi; Mano, Tadaaki

doi:10.1016/s0165-1838(97)00014-3

Cited by 95 publications

(81 citation statements)

References 16 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Disease states may also augment or attenuate SSNA responses to stress. Iwase et al (6) observed augmented stress-induced increases in SSNA and sweating in subjects with palmoplantar hyperhydrosis compared with controls. By furthering our understanding of the determinants of stimulus-induced increases in SSNA and cutaneous end-organ responses, we may be able to gain insight into underlying mechanisms causing these altered responses.…”

Section: Discussionmentioning

confidence: 98%

Determinants of skin sympathetic nerve responses to isometric exercise

Wilson

Dyckman²,

Ray³

2006

Journal of Applied Physiology

View full text Add to dashboard Cite

Determinants of skin sympathetic nerve responses to isometric exercise. J Appl Physiol 100: 1043-1048, 2006. First published November 10, 2005 doi:10.1152/japplphysiol.00579.2005.-Exercise-induced increases in skin sympathetic nerve activity (SSNA) are similar between isometric handgrip (IHG) and leg extension (IKE) performed at 30% of maximal voluntary contraction (MVC). However, the precise effect of exercise intensity and level of fatigue on this relationship is unclear. This study tested the following hypotheses: 1) exercise intensity and fatigue level would not affect the magnitude of exercise-induced increase in SSNA between IHG and IKE, and 2) altering IHG muscle mass would also not affect the magnitude of exercise-induced increase in SSNA. In protocol 1, SSNA (peroneal microneurography) was measured during baseline and during the initial and last 30 s of isometric exercise to volitional fatigue in 12 subjects who randomly performed IHG and IKE bouts at 15, 30, and 45% MVC. In protocol 2, SSNA was measured in eight subjects who performed one-arm IHG at 30% MVC with the addition of IHG of the contralateral arm in 10-s intervals for 1 min. Exercise intensity significantly increased SSNA responses during the first 30 s of IHG (34 Ϯ 13, 70 Ϯ 11, and 92 Ϯ 13% change from baseline) and IKE (30 Ϯ 17, 69 Ϯ 12, and 76 Ϯ 13% change from baseline) for 15, 30, and 45% MVC. During the last 30 s of exercise to volitional fatigue, there were no significant differences in SSNA between exercise intensities or limb. SSNA did not significantly change between onearm and two-arm IHG. Combined, these data indicate that exerciseinduced increases in SSNA are intensity dependent in the initial portion of isometric exercise, but these differences are eliminated with the development of fatigue. Moreover, the magnitude of exerciseinduced increase in SSNA responses is not dependent on either muscle mass involved or exercising limb. skin blood flow; sweat rate; and microneurography SYMPATHETIC OUTFLOW TO THE skin is increased during isometric and rhythmic exercise (7,12,26). This exercise-induced increase in skin sympathetic nerve activity (SSNA) is controlled by the engagement of central command and activation of muscle mechanoreceptors, and it may be controlled, under very specific conditions, by activation of muscle metaboreceptors (11). Unlike muscle sympathetic nerve activity, the precise determinants of exercise-induced increases in SSNA are equivocal.Previous studies indicate that the exercise-induced increases in SSNA are intensity dependent to ϳ45% of maximal voluntary contraction (MVC) and that level of effort modulates SSNA responses to isometric exercise (27,28). Seals (20) observed another determinant to exercise-induced increases in SSNA by demonstrating that the level of fatigue may be a prime factor regardless of exercise intensity. In these experiments, he observed no difference in SSNA responses between higher exercise intensities (i.e., 45 and 60% MVC) during isometric handgrip (IHG) at and near volitional fatigu...

show abstract

Section: Discussionmentioning

confidence: 98%

Determinants of skin sympathetic nerve responses to isometric exercise

Wilson

Dyckman²,

Ray³

2006

Journal of Applied Physiology

View full text Add to dashboard Cite

show abstract

“…However, different changes and regional differences in sympathetic activation were reported (Iwase et al, 1997;Kondo et al, 2003;Koba et al, 2006). Iwase et al (1997) reported that the increase of sympathetic activity in the peroneal nerve is almost 200 % by heating, whereas that in the tibial is below 100 %. On the other hand, those in the peroneal and tibial were similar to the response of mental arithmetic.…”

Section: Discussionmentioning

confidence: 99%

Ambient Temperature Affects Glabrous Skin Vasculature and Sweating Responses to Mental Task in Humans

Hayashi

Someya

Hirooka

et al. 2008

J Physiol Anthropol

View full text Add to dashboard Cite

Abstact We compared responses in heart rate (HR), mean blood pressure (MAP), sweating rate (SR), sweating expulsion (SwE), and skin vascular conductance (VC) to mental task among different ambient temperature (Ta) conditions, i.e., 12, 16, 20, and 24°C. Seven subjects (27Ϯ5 yrs, 64Ϯ14 kg) underwent a 2-min color word conflict test (CWT) after 2 mins of baseline data acquisition following a 20-min resting period. All subjects wore long sleeve shirts and long pants. The skin blood flow was measured with a laser Doppler probe on the left index finger pulp to calculate skin VC, and the SR and sweating expulsion (SwE) were measured with a ventilated capsule on the left thenar. CWT significantly increased the HR and MAP, while there was no significant effect of Ta on the magnitudes of these responses. CWT significantly decreased the skin VC when the Ta was 24°C, whereas it significantly increased the skin VC when the Ta was 12 or 16°C. CWT significantly increased SR and SwE in all Ta conditions, and the SwE was greater in warmer conditions. These findings suggest that different ambient temperatures induce different responses in finger skin vasculature to mental task, implying the independent response of cutaneous vasomotor tone and sweat glands in glabrous skin to mental task.

show abstract

“…However, controversial results have been reported concerning whether cardiac autonomic functions are altered in this disorder. While some authors (Shih et al 1983;Noppen et al 1995;Iwase et al 1997;Kingma et al 2002) reported an overfunctioning of sympathetic fibers running through T2-3 as the cause of palmar hyperhidrosis, the others found no evidence of cardiac sympathetic dysfunction, in contrast, observed parasympathetic dysfunction at autonomic stimulation in hyperhidrotic subjects compared to normal subjects (Birner et al 2000;Senard et al 2003). Also, Senard et al (2003) showed that there was no difference with respect to plasma noradrenalin levels between hyperhidrotic and healthy control subjects either in resting or during Head-up tilt test.…”

Section: Discussionmentioning

confidence: 96%

“…The autonomic nervous system regulates heart rate and cardiac contractile via a dual supply of sympathetic and parasympathetic nerves and, dysregulation of autonomic nervous system causes various cardiac disorders (Ishizuka et al 1987;Matsuyama et al 1992). Accordingly, several previous studies have investigated cardiovascular function in patients with essential hyperhidrosis in order to demonstrate putative role of sympathetic hyperactivity (Shih et al 1983;Noppen et al 1995;Iwase et al 1997;Birner et al 2000;Kingma 2002;Senard et al 2003). However, controversial results have been reported concerning whether cardiac autonomic functions are altered in this disorder.…”

Section: Discussionmentioning

confidence: 99%

Impaired Left Ventricular Filling in Patients with Essential Hyperhidrosis: An Echo-Doppler Study

Sağlam

Esen

Barutçu

et al. 2006

Tohoku J. Exp. Med.

View full text Add to dashboard Cite

Essential hyperhidrosis is a well recognized dermatologic and neurologic disorder, characterized by excessive sweating of the eccrine sweat glands. It is also associated with cardiac autonomic dysfunction because sympathetic fibers to eccrine glands of palms of the hand arise from stellate and upper thoracic ganglia, which also innervate the heart. In this study, we investigated cardiac function in patients with essential hyperhidrosis by conventional and tissue Doppler imaging methods. Eighteen subjects with essential hyperhidrosis and eighteen control subjects were included in this study. Pulsed-wave Doppler parameters of the left and right ventricles, which represent diastolic filling abnormalities, were obtained by conventional Doppler and tissue Doppler imaging. Isovolumetric relaxation time, isovolumetric contraction time, ejection time and myocardial performance index were also calculated. Mitral inflow peak early (E M ) and late (A M ) velocities and E M /A M ratio, which represent diastolic filling of left ventricle, were significantly lower in hyperhidrotic subjects than in controls. Also, mitral lateral annulus early and late velocities and early/late velocity ratio, reflecting diastolic filling of left ventricle, were significantly lower in hyperhidrotic subjects than those of controls. However, there were no differences between hyperhidrotic subjects and control subjects with regard to the other echocardiographic indices of left and right ventricle diastolic functions. In conclusion, decreased mitral inflow suggests left ventricle diastolic dysfunction in patients with essential hyperhidrosis. This indicates that hyperactivity of sympathetic nervous system in patient with hyperhidrosis may alter cardiac function in long term. essential hyperhidrosis; cardiac function; echocardiography

show abstract

Altered response in cutaneous sympathetic outflow to mental and thermal stimuli in primary palmoplantar hyperhidrosis

Cited by 95 publications

References 16 publications

Determinants of skin sympathetic nerve responses to isometric exercise

Determinants of skin sympathetic nerve responses to isometric exercise

Ambient Temperature Affects Glabrous Skin Vasculature and Sweating Responses to Mental Task in Humans

Impaired Left Ventricular Filling in Patients with Essential Hyperhidrosis: An Echo-Doppler Study

Contact Info

Product

Resources

About