Altered response in renal blood flow and oxygen tension to contrast media                in diabetic rats

Palm, Fredrik; Carlsson, Per‐Ola; Hansell, Peter; Hellberg, Olof; Nygren, Anders; Liss, Per

doi:10.1080/j.1600-0455.2003.00076.x

Cited by 14 publications

(7 citation statements)

References 27 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In a review by Pflueger et al [21] it was suggested that adenosine is an important contributor to CM-induced acute renal failure primarily during diabetes mellitus, which is linked to a higher sensitivity of the renal vasculature to adenosine. In a recent study from our laboratory [25], we found that the renal PO 2 response to CM is altered in an experimental model of diabetes mellitus as compared with that in normal rats. We, however, concluded that mechanisms other than haemodynamic mechanisms were responsible for this alteration in response to CM injection.…”

Section: Discussionmentioning

confidence: 82%

Adenosine A1 receptors in contrast media-induced renal dysfunction in the normal rat

et al. 2004

View full text Add to dashboard Cite

Renal vasoconstriction with resultant tissue hypoxia, especially in the renal medulla, has been suggested to play a role in contrast media (CM)-induced nephropathy. In this study we investigated the effects of injection of the non-ionic low-osmolar CM iopromide with and without pretreatment with the selective adenosine A1-receptor antagonist DPCPX. The effects were evaluated on regional renal blood flow, outer medullary oxygen tension (PO2) and urine output in normal anaesthetised rats. A laser-Doppler technique was used for recording haemodynamic changes while oxygen microelectrodes were used for oxygen measurements. The A1-receptor antagonist per se elevated glomerular filtration rate (+44%), cortical blood flow (+15%) and urine output (threefold) while reducing outer medullary PO2 (-24%). Administration of CM reduced outer medullary blood flow (OMBF; -26%) and PO2 (-80%) but did not affect cortical blood flow. Urine output increased 28-fold by CM while arterial blood pressure was reduced. The CM-mediated effect on haemodynamics, PO2, urine output and blood pressure was unaffected by the A1-receptor antagonist. Adenosine A1-receptors are not important mediators of the depression of outer medullary blood flow and PO2 caused by the CM iopromide in the normal rat; however, A1-receptors are tonically active to regulate renal haemodynamics, PO2 and urine production during normal physiological conditions.

show abstract

Section: Discussionmentioning

confidence: 82%

Adenosine A1 receptors in contrast media-induced renal dysfunction in the normal rat

et al. 2004

View full text Add to dashboard Cite

show abstract

“…Previous research on CIN has also been limited by the methods used to determine renal blood flow (RBF) and partial pressure of oxygen (pO 2 ). For example, the laser-Doppler probe and Clark-type microelectrodes (12) are unable to measure hemodynamics and oxygenation in the global kidney. Moreover, the invasiveness of these methods disallows the longitudinal studies.…”

Section: Introductionmentioning

confidence: 99%

The serial effect of iodinated contrast media on renal hemodynamics and oxygenation as evaluated by ASL and BOLD MRI

Zhang

Wang

Yang

et al. 2012

Contrast Media & Molecular

View full text Add to dashboard Cite

Contrast-induced nephropathy is a prevalent cause of renal failure, and the mechanisms underlying this injury are not fully understood. We utilized noninvasive functional MRI in order to determine the serial effect of a single administration of iodinated contrast media (CM) on renal hemodynamics and oxygenation. Fifteen rabbits were randomized to receive an intravenous injection of CM (i.e. iopamidol-370; 6 ml kg(-1) body weight) or an equivalent amount of 0.9% saline. Both arterial spin-labeling and blood oxygen level-dependent imaging sequences were performed at 24 h before and at intervals of 1, 24, 48 and 72 h after injection to obtain serial renal blood flow (RBF) and relative spin-spin relaxation rate (R(2)*). Results showed that, in the iopamidol group, the mean cortical RBF decreased at 1 h (p = 0.04 vs baseline), reached its minimum at 24 h (p = 0.01) and gradually returned to baseline by 48 h (p = nonsignificant, NS). The outer medullary RBF decreased to its minimum by 24 h (p = 0.00) and remained less than baseline until 72 h. R(2)* in inner stripes was dramatically increased at 1 h (p = 0.00), remained elevated at 24 h (p = 0.05), but returned to baseline by 48 h (p = NS). R(2)* values within the cortex and outer stripes and inner medulla were slightly increased, but the changes did not reach a statistical significance (p = NS). Saline did not produce positive change in either RBF or R(2)* within different compartments of the kidney. We conclude that iopamidol is associated with a relatively longer-term hypoperfusion in whole kidney and decreased oxygen level in the inner stripes of the outer medulla.

show abstract

“…With increased usage of iodinated CM during radiological or interventional procedures, CIN has become one of the most prevalent causes of acute renal failure (ARF), especially in patients suffering from diabetes or cardiovascular pathology (5)(6)(7). The pathogenesis of CIN, however, is currently unclear (8) Previous research has used invasive laser-Doppler probe or Clark-type microelectrodes to demonstrate that the renal ischemia and anoxia plays an important role in the development of CIN (9). To date, a noninvasive technique for the investigation of functional alterations within the kidney has not been well established.…”

mentioning

confidence: 99%

Time course study on the effects of iodinated contrast medium on intrarenal water transport function using diffusion‐weighted MRI

Wang

Zhang

Yang

et al. 2012

Magnetic Resonance Imaging

View full text Add to dashboard Cite

Purpose: To assess the effects of intravenous-injected iodinated contrast medium (CM) on intrarenal water diffusion using noninvasive diffusion-weighted MRI (DW-MRI). Materials and Methods:Ten New Zealand White rabbits were randomized to receive a 6 mL/kg body weight intravenous injection of clinically used iopamidol-370 (n ¼ 7) or an equivalent amount of 0.9% physiological saline (n ¼ 3). A sequential DW-MRI was performed to estimate the intrarenal apparent diffusion coefficient (ADC) at 24 h before and 1 h, 24 h, 48 h, and 72 h after administration.Results: Iopamidol produced a progressive ADC reduction in inner stripes of the renal outer medulla (IS) by 13.92% (P ¼ 0.05) at 1 h, 17.52% (P ¼ 0.02) at 24 h, 20.23% (P ¼ 0.01) at 48 h and 16.31% (P ¼ 0.04) at 72 h after injection. Cortical ADC was decreased by 14.14% (P ¼ 0.01) at 48 h and 14.12% (P ¼ 0.01) at 72 h after injection. Iopamidol produced slight decrease of ADCs in outer stripes of the outer medulla (OS) and inner medulla (IM) of kidney but without statistical difference. In control group, no significant ADC changes was observed in each anatomic compartment due to saline injection (P > 0.05). Conclusion:As demonstrated by DW-MRI, intravenous iopamidol injection resulted in a successive reduction of intrarenal water diffusion, particularly in IS of kidney. This MR technique may be used as a noninvasive tool to perform a time course study of the pathogenesis associated with contrast-induced nephropathy (CIN).

show abstract

Altered response in renal blood flow and oxygen tension to contrast media in diabetic rats

Cited by 14 publications

References 27 publications

Adenosine A1 receptors in contrast media-induced renal dysfunction in the normal rat

Adenosine A1 receptors in contrast media-induced renal dysfunction in the normal rat

The serial effect of iodinated contrast media on renal hemodynamics and oxygenation as evaluated by ASL and BOLD MRI

Time course study on the effects of iodinated contrast medium on intrarenal water transport function using diffusion‐weighted MRI

Contact Info

Product

Resources

About