Altered responsiveness of regional brain dopamine and DOPAC levels to systemic administration of quinpirole, a dopamine D2 agonist, in DOCA/NaCl-hypertensive rats

ROLE OF HYPOTHALAMIC α2‐ADRENOCEPTOR ACTIVITY IN FRUCTOSE‐INDUCED HYPERTENSION

“…However, in central nuclei richly innervated with noradrenergic neurons, DOPAC may be derived from dopamine (the precursor of NA) that escapes vesicular uptake and is deaminated 25 . Therefore, although it is likely that most of the DOPAC assayed in AHA dialysates was derived from dopaminergic neurons, 26 DOPAC formation within noradrenergic nerve terminals may have also contributed to the extracellular levels 27 . We studied the effect of yohimbine perfusion on 5‐HIAA dialysate concentrations as an index of serotoninergic activity.…”

Acute administration of a dopamine D2/D3 receptor agonist alters behavioral and neural parameters in adult zebrafish

“…For example, after quinpirole administration, glutamate is reported to have decreased levels in nucleus accumbens, globus pallidus, and striatum, and increased levels in the nucleus accumbens and substantia nigra (Abarca et al, 1995;Beggiato et al, 2016;Biggs et al, 1997;Dalia et al, 1998;Escobar et al, 2015;Ferraro et al, 2012a;Kalivas et al, 1997;Krügel et al, 2004;Tanganelli et al, 2004). Dopamine has been shown to have decreased levels in the nucleus accumbens and prefrontal cortex, and when evaluated in the whole brain, the overall level of dopamine was found to be increased (Brodnik et al, 2013;Chen et al, 1987;De Haas et al, 2011;Escobar et al, 2015;Ferré & Artigas, 1995;Koeltzow et al, 2003;Liu & Steketee, 2011;Sullivan et al, 1998;Thorré et al, 1998). For serotonin, an increased level in the dorsal raphe and decreased level in the substantia nigra was observed, while no alterations were found in the nucleus accumbens (Ferré & Artigas, 1995;Koeltzow et al, 2003;Martín-Ruiz et al, 2001;Thorré et al, 1998).…”

Acute administration of a dopamine D2/D3 receptor agonist alters behavioral and neural parameters in adult zebrafish

“…For example, after quinpirole administration, glutamate is reported to have decreased levels in nucleus accumbens, globus pallidus, and striatum, and increased levels in the nucleus accumbens and substantia nigra (Abarca et al, 1995; Beggiato et al, 2016; Biggs et al, 1997; Dalia et al, 1998; Escobar et al, 2015; Ferraro et al, 2012a; b; Kalivas et al, 1997; Krügel et al, 2004; Tanganelli et al, 2004). Dopamine has been shown to have decreased levels in the nucleus accumbens and prefrontal cortex, and when evaluated in the whole brain, the overall level of dopamine was found to be increased (Brodnik et al, 2013; Chen et al, 1987; De Haas et al, 2011; Escobar et al, 2015; 2017; Ferré & Artigas, 1995; Koeltzow et al, 2003; Liu & Steketee, 2011; Sullivan et al, 1998; Thorré et al, 1998). For serotonin, an increased level in the dorsal raphe and decreased level in the substantia nigra was observed, while no alterations were found in the nucleus accumbens (Ferré & Artigas, 1995; Koeltzow et al, 2003; Martín-Ruiz et al, 2001; Thorré et al, 1998).…”