Altered resting-state connectivity in adolescent cannabis users

Orr, Catherine; Morioka, R; Behan, Brendan; Datwani, Sameer; Doucet, Marika; Ivanović, Jelena; Kelly, Clare; Weierstall, Karen; Watts, Richard; Smyth, Bobby P; Garavan, Hugh

doi:10.3109/00952990.2013.848213

Cited by 72 publications

(65 citation statements)

References 56 publications

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“…An illustrative example comes the cannabis literature. Initial functional connectomics studies of chronic cannabis use in adolescence have already furnished a number of findings (Behan et al, 2014; Orr et al, 2013), which are particularly intriguing given recent secular trends in the legal status of cannabis in many western societies. However, the reliance of these efforts on retrospective designs precludes determinations of whether abnormalities in brain structure and function were pre-existing deficits or sequelae of early substance use (for review see: Jacobus and Tapert, 2014).…”

Section: Section 1: Developmental Miswiring: Emerging Modelsmentioning

confidence: 99%

Unraveling the Miswired Connectome: A Developmental Perspective

Martino

Fair

Kelly

et al. 2014

Neuron

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320

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Summary The vast majority of mental illnesses can be conceptualized as developmental disorders of neural interactions within the connectome, or developmental miswiring. The recent maturation of pediatric in vivo brain imaging is bringing within reach the identification of clinically meaningful brain-based biomarkers of developmental disorders. Even more auspicious, is the ability to study the evolving connectome throughout life, beginning in utero, which promises to move the field from topological phenomenology to etiological nosology. Here, we scope advances in pediatric imaging of the brain connectome as the field faces the challenge of unraveling developmental miswiring. We highlight promises while also providing a pragmatic review of the many obstacles ahead that must be overcome to significantly impact public health.

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Section: Section 1: Developmental Miswiring: Emerging Modelsmentioning

confidence: 99%

Unraveling the Miswired Connectome: A Developmental Perspective

Martino

Fair

Kelly

et al. 2014

Neuron

Self Cite

320

307

View full text Add to dashboard Cite

show abstract

“…Increased parietal-cerebellar, right hemispheric, and PFC (Behan et al, 2013; Orr et al, 2013) and decreased frontal-cerebellar interhemispheric and temporal cortex (Houck et al, 2013; Orr et al, 2013) resting state connectivity has been reported in adolescent cannabis users. Studies have also found increased functional connectivity between PFC-occipital (Harding et al, 2012), and parietal-cerebellar (Behan et al, 2013) brain regions in adolescent cannabis users while engaging in cognitive tasks.…”

Section: Impacts Of Regular Cannabis Use On Neurocognition In Teenmentioning

confidence: 99%

Considering Cannabis: The Effects of Regular Cannabis Use on Neurocognition in Adolescents and Young Adults

et al. 2014

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Thirty-six percent of high school seniors have used cannabis in the past year, and an alarming 6.5% smoked cannabis daily, up from 2.4% in 1993 (Johnston et al., 2013). Adolescents and emerging adults are undergoing significant neurodevelopment and animal studies suggest they may be particularly vulnerable to negative drug effects. In this review, we will provide a detailed overview of studies outlining the effects of regular (at least weekly) cannabis use on neurocognition, including studies outlining cognitive, structural and functional findings. We will also explore the public health impact of this research.

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“…Therefore, cannabis exposure may influence reward circuit function by altering the connectivity of key regions. Congruently, several studies have reported altered connectivity in association with cannabis use, including aberrant resting-state functional connectivity (rsFC) of the default mode, insula, and lateral visual networks among cannabis users (17, 18), reduced interhemispheric rsFC among cannabis dependent adolescents (19), and heightened rsFC of the medial frontal gyrus in association with cannabis use among high risk youth (20). Furthermore, increased functional connectivity between the PFC and occipitoparietal cortex has been reported in association with increased cognitive control demands among heavy cannabis users relative to controls (21), and cannabis dependent individuals display heightened functional connectivity between the PFC and basal ganglia during successful inhibition, relative to non-dependent cannabis users (22).…”

Section: Introductionmentioning

confidence: 99%

Nucleus accumbens functional connectivity at age 20 is associated with trajectory of adolescent cannabis use and predicts psychosocial functioning in young adulthood

et al. 2017

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Aims 1) To identify trajectories of cannabis use across adolescence, 2) to measure the influence of cannabis use characteristics on functional connectivity of the nucleus accumbens (NAcc), and 3) to assess whether patterns of functional connectivity related to cannabis use are associated with psychosocial functioning 2 years later. Design The Pitt Mother & Child Project (PMCP) is a prospective, longitudinal study of male youth at high risk for psychopathology based on family income and gender. Setting Participants were recruited between age 6–17 months from the Women, Infants, and Children Nutritional Supplement program (WIC) in the Pittsburgh, Pennsylvania area. Participants N=158 PMCP young men contributed fMRI and substance use data at age 20. Measurements Latent class growth analysis was used to determine trajectories of cannabis use frequency from age 14–19. Psychophysiological interaction (PPI) analysis was used to measure functional connectivity between the NAcc and prefrontal cortex (PFC). Adolescent cannabis use trajectory, recent frequency of use, and age of initiation were considered as developmental factors. We also tested whether functional connectivity was associated with depressive symptoms, anhedonia, and educational attainment at age 22. Findings We identified three distinct trajectories of adolescent cannabis use, characterized by stable high, escalating, or stable low use. Cannabis use trajectory group had a significant effect on NAcc functional connectivity to the medial PFC (F=11.32, Z=4.04, pFWE-corr=.000). The escalating trajectory group displayed a pattern of negative NAcc-mPFC connectivity that was linked to higher levels of depressive symptoms (r=−.17, p=.041), anhedonia (r=−.19, p=.028), and lower educational attainment (t=−2.77, p=.006) at age 22. Conclusions Pattern of cannabis use frequency across adolescence in US youth could have consequences for mood symptoms and educational attainment in early adulthood via altered function in neural reward circuitry.

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Altered resting-state connectivity in adolescent cannabis users

Cited by 72 publications

References 56 publications

Unraveling the Miswired Connectome: A Developmental Perspective

Unraveling the Miswired Connectome: A Developmental Perspective

Considering Cannabis: The Effects of Regular Cannabis Use on Neurocognition in Adolescents and Young Adults

Nucleus accumbens functional connectivity at age 20 is associated with trajectory of adolescent cannabis use and predicts psychosocial functioning in young adulthood

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