Altered resting-state functional connectivity of medial frontal cortex in overweight individuals: Link to food-specific intentional inhibition and weight gain

Liu, Xinyuan; Chen, Ximei; Li, Qingqing; Xiang, Guo; Li, Wei; Xiao, Mingzhao; Du, Xiangdong; Song, Shiqing; Liu, Yong; Chen, Hong

doi:10.1016/j.bbr.2022.114003

Cited by 4 publications

(5 citation statements)

References 49 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The results of the ANOVA test are presented in Table 7, indicating a significant difference in coherence maps between the two groups (F = 9.28, p-value = 0.004). These findings suggest that overweight status impacts the functional connectivity between the left and right prefrontal cortex, potentially affecting cognitive functions associated with overeating behaviours [5,29].…”

Section: Correlations Between Different Bmis and Fp1-fp2 Coherencementioning

confidence: 88%

“…Another study by Schmidt et al, [17] focused on examining the relationship between neural activities during the resting state and children with overweight status, but EEG signals differ based on age, rendering their results inapplicable to adults aged over 15 years [18]. Stephan et al, [29] observed that overweight individuals exhibit altered resting-state functional connectivity (rsFC) in the medial frontal cortex (MFC) using fMRI data acquisition. Furthermore, the previous studies employed the power spectral density technique for EEG feature extraction and applied the ANOVA test to identify the most significant band related to overweight subjects compared to the normal weight group as controls.…”

Section: Discussionmentioning

confidence: 99%

“…Stephan et al, [29] Overweight individuals are expected to exhibit altered resting-state functional connectivity (rsFC) in the regions of the frontal cortex, as compared to normal-weight individuals.…”

Section: Discussionmentioning

confidence: 99%

“…Obesity and overweight are associated with impaired decision-making and cognitive inflexibility, with opposing patterns of impulsive behaviour. Specific areas of the PFC show alterations in activation and extent of dysfunction in these conditions [20,29]. Modulating excitability in the dorsolateral prefrontal cortex (DLPFC) influences the liking but not the wanting of highly palatable foods, implying involvement in the hedonic experience of eating [21].…”

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

Assessing the Relationship Between Body Mass Index and Neural Activity of Prefrontal Cortex in Overweight Adults Using EEG-Resting State Data: A Wavelet Transform Analysis

Mohammed Isam Al-Hiyali,

Asnor Juraiza Ishak,

Maged Saleh Saeed Al-Quraishi

et al. 2024

ARASET

View full text Add to dashboard Cite

Neuroscientific evidence suggests that weight gain may be associated with changes in brain lobes' volume and function, as well as impulsive behaviour related to eating. However, it remains unclear whether impulsivity behaviour in overweight subjects is linked to abnormal activity in the resting state. To address this question, we propose a novel method to assess the relationship between different levels of body mass index (BMI) and neural activity of the prefrontal cortex (PFC) using electroencephalography (EEG) resting state data. EEG signals recorded during open-eye resting state from 36 subjects were divided into two groups based on BMI: overweight and normal weight subjects. We applied wavelet transform technique to compute the power for decomposed EEG bands and extracted coherence maps to assess the functional connectivity of the PFC. The one-way analysis of variance (ANOVA) was employed to assess the difference in EEG variables between the study groups. The results show a significant increase in the power of the sub-Theta band (4.49-5.34) Hz in overweight subjects compared to normal weight subjects (p-value = 0.001), as well as dysfunctional connectivity between left-right prefrontal sites in the overweight group with decreasing coherence function. These outcomes suggest that the specific PFC-EEG signals observed in overweight individuals are consistent with EEG patterns seen in other impulsivity-related diseases. Therefore, our findings reveal a specific EEG pattern in overweight adults that could be potentially utilized in developing neurotherapy-based treatment methods for overweight management.

show abstract

Section: Correlations Between Different Bmis and Fp1-fp2 Coherencementioning

confidence: 88%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Assessing the Relationship Between Body Mass Index and Neural Activity of Prefrontal Cortex in Overweight Adults Using EEG-Resting State Data: A Wavelet Transform Analysis

Mohammed Isam Al-Hiyali,

Asnor Juraiza Ishak,

Maged Saleh Saeed Al-Quraishi

et al. 2024

ARASET

View full text Add to dashboard Cite

show abstract

“…As BMI was a covariate in the analyses, alterations in BED may be part of the pathology, but whether they are a cause or effect of illness is unclear [39]. The results of a 2022 study by Xinyuan and colleagues [40] suggested that altered functional connections between the medial frontal cortex and regions associated with reward and maladaptive eating may be a key aspect of the neural mechanisms of food-specific intentional inhibition in individuals with an overweight status [40]. Despite these results, it is important to bear in mind that the directionality of the relationship between obesity and executive functioning is still unclear.…”

Section: Introductionmentioning

confidence: 99%

Frontal Lobe Functions and Quality of Life in Individuals with Obesity with and without Binge Eating Disorder

Gameiro,

Rosa,

Faria

2023

Endocrines

View full text Add to dashboard Cite

Frontal lobe functions (FLFs) play an important role in human behavioral regulation and can be a determinant of eating behavior. The aim of this study was to analyse FLFs in individuals with obesity, with and without binge eating disorder (BED), compared to individuals with normal weight (NW), and to analyse the effect of sex and binge disorder on quality of life, with age and BMI as covariates. A total of 114 participants, comprising three different groups (NW individuals, individuals with obesity but without BED, and individuals with obesity and BED), completed the Frontal Assessment Battery (FAB) and Impact of Weight on Quality of Life (IWQOL-lite) questionnaires. The results showed that individuals with obesity, with and without BED, have poorer frontal lobe functioning than the NW group. Individuals with obesity and BED have lower performance in terms of FLFs than individuals with obesity but without BED. Male participants have a higher perception of quality of life in all dimensions, with women showing lower values in self-esteem and sex life. Individuals with obesity and BED show greater weaknesses in physical function. These results suggest that low FLFs and worse quality of life characterize individuals with obesity, and this is more evident in these individuals with BED.

show abstract

Relationship between functional connectivity and weight-gain risk of antipsychotics in schizophrenia

Dodd,

Legget,

Cornier

et al. 2024

Schizophrenia Research

View full text Add to dashboard Cite

Altered resting-state functional connectivity of medial frontal cortex in overweight individuals: Link to food-specific intentional inhibition and weight gain

Cited by 4 publications

References 49 publications

Assessing the Relationship Between Body Mass Index and Neural Activity of Prefrontal Cortex in Overweight Adults Using EEG-Resting State Data: A Wavelet Transform Analysis

Assessing the Relationship Between Body Mass Index and Neural Activity of Prefrontal Cortex in Overweight Adults Using EEG-Resting State Data: A Wavelet Transform Analysis

Frontal Lobe Functions and Quality of Life in Individuals with Obesity with and without Binge Eating Disorder

Relationship between functional connectivity and weight-gain risk of antipsychotics in schizophrenia

Contact Info

Product

Resources

About