Altered Secretion of Adrenomedullary a-Cells in Rats After Developmental Exposure to Low-Dose Dichlorodiphenyltrichloroethane

Yaglova, N. V.; Цомартова, Д. А.; Yaglov, V. V.; Обернихин, С. С.; Назимова, С. В.

doi:10.31088/2226-5988-2018-27-3-30-34

Cited by 2 publications

(3 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The revealed changes were most pronounced in norepinephrine-producing cells. In the rats exposed to DDT both prenatally and postnatally, increased numbers of primary lysosomes in adrenal chromaffin cells and focal hemorrhages were found [ 76 ]. In the rats exposed to DDT postnatally only, the signs of increased synthetic activity and the formation of secretory granules, but not their release, were revealed [ 76 ].…”

Section: Studies On the Effects Of Low Doses Of Ddt On The Adrenal Glandsmentioning

confidence: 99%

“…In the rats exposed to DDT both prenatally and postnatally, increased numbers of primary lysosomes in adrenal chromaffin cells and focal hemorrhages were found [ 76 ]. In the rats exposed to DDT postnatally only, the signs of increased synthetic activity and the formation of secretory granules, but not their release, were revealed [ 76 ]. This suggested that DDT disrupts the mechanisms of secretory material release from chromaffin cells due to a decrease in the number of mitochondria involved in the exocytosis of granules [ 74 ].…”

Section: Studies On the Effects Of Low Doses Of Ddt On The Adrenal Glandsmentioning

confidence: 99%

See 1 more Smart Citation

Dichlorodiphenyltrichloroethane and the Adrenal Gland: From Toxicity to Endocrine Disruption

Timokhina

Yaglov

Назимова

2021

Toxics

View full text Add to dashboard Cite

Endocrine disruptors are exogenous compounds that pollute the environment and have effects similar to hormones when inside the body. One of the most widespread endocrine disruptors in the wild is the pesticide dichlorodiphenyltrichloroethane (DDT). Toxic doses of DDT are known to cause cell atrophy and degeneration in the adrenal zona fasciculata and zona reticularis. Daily exposure in a developing organism to supposedly non-toxic doses of DDT have been found to impair the morphogenesis of both the cortex and the medulla of the adrenal glands, as well as disturbing the secretion of hormones in cortical and chromaffin cells. Comparison of high and very low levels of DDT exposure revealed drastic differences in the morphological and functional changes in the adrenal cortex. Moreover, the three adrenocortical zones have different levels of sensitivity to the disruptive actions of DDT. The zona glomerulosa and zona reticularis demonstrate sensitivity to both high and very low levels of DDT in prenatal and postnatal periods. In contrast, the zona fasciculata is less damaged by low (supposedly non-toxic) exposure to DDT and its metabolites but is affected by toxic levels of exposure; thus, DDT exerts both toxic and disruptive effects on the adrenal glands, and sensitivity to these two types of action varies in adrenocortical zones. Disruptive low-dose exposure leads to more severe affection of the adrenal function.

show abstract

Section: Studies On the Effects Of Low Doses Of Ddt On The Adrenal Glandsmentioning

confidence: 99%

Section: Studies On the Effects Of Low Doses Of Ddt On The Adrenal Glandsmentioning

confidence: 99%

Dichlorodiphenyltrichloroethane and the Adrenal Gland: From Toxicity to Endocrine Disruption

Timokhina

Yaglov

Назимова

2021

Toxics

View full text Add to dashboard Cite

show abstract

“…We earlier found [ 7 , 8 ] that prenatal and postnatal exposure of rats to low doses of DDT leads to a decrease in norepinephrine and epinephrine concentration in the systemic circulation. In rats, epinephrine produced by the adrenal glands accounts for more than 80% of its total content in the systemic circulation, and the major proportion of norepinephrine enters the blood from the sympathetic part of the autonomic nervous system [ 7 ].…”

Section: Introductionmentioning

confidence: 99%

Morphological and Cytophysiological Changes in the Adult Rat Adrenal Medulla after Prenatal and Postnatal Exposure to Endocrine-Disrupting DDT

et al. 2020

Self Cite

View full text Add to dashboard Cite

The aim of the investigation was to study morphological and cytophysiological changes in the adult rat adrenal medulla after prenatal and postnatal exposure to endocrine-disrupting chemical dichlorodiphenyltrichloroethane (DDT). Materials and Methods. The experiment was carried out on male Wistar rats (n=30). The rats were exposed to low doses of DDT during prenatal and postnatal development (n=10) and during postnatal development (n=10) only. The average daily intake of DDT by rats was 3.30±0.14 μg/kg. The control (n=10) and experimental animals were sacrificed at the age of 10 weeks (post-puberty), when rat adrenal glands reached their maximum development. Histological samples of the equatorial sections of the adrenal glands were prepared. The adrenal medulla was studied using light microscopy and computer morphometry. Immunohistochemistry was performed to evaluate tyrosine hydroxylase expression in chromaffin cells. Plasma epinephrine content was measured using enzyme-linked immunosorbent assay. Results. Postnatal exposure of rats to low doses of the endocrine disruptor was found to interfere with adrenal medulla development and cytophysiology of chromaffin cells. Prenatal and postnatal exposure resulted in more profound delay in adrenal medulla development of adult rats as compared to the values of rats exposed postnatally, which was manifested by reduced area of the adrenal medulla and reduced total area of chromaffin cells in its section. Postnatal exposure is manifested by more significant functional disorders including decreased synthesis of tyrosine hydroxylase enzyme in the cytoplasm of chromaffin cells and elevated number of tyrosine-hydroxylasenegative cells in the medulla section, leading to a decrease in plasma epinephrine concentration. Conclusion. Exposure to low doses of DDT in the early stages of development leads to morphological and cytophysiological changes in the adult rat adrenal medulla and, therefore, reduced functional activity of chromaffin cells, which allows considering the endocrine disruptor DDT a potential risk factor disrupting the function of the neuroendocrine system.

show abstract

Altered Secretion of Adrenomedullary a-Cells in Rats After Developmental Exposure to Low-Dose Dichlorodiphenyltrichloroethane

Cited by 2 publications

References 0 publications

Dichlorodiphenyltrichloroethane and the Adrenal Gland: From Toxicity to Endocrine Disruption

Dichlorodiphenyltrichloroethane and the Adrenal Gland: From Toxicity to Endocrine Disruption

Morphological and Cytophysiological Changes in the Adult Rat Adrenal Medulla after Prenatal and Postnatal Exposure to Endocrine-Disrupting DDT

Contact Info

Product

Resources

About