Altered serum cytokine and immunoglobulin levels in the workers exposed to antimony

Kim, Heon; Heo, Yong; Sy, Oh; Kj, Lee; Da, Lawrence

doi:10.1191/096032799678839400

Cited by 33 publications

(13 citation statements)

References 42 publications

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“…Interleukin-4 (IL-4), IL-10, IFNγ, and Tumor necrosis factor (TNF)α in culture supernatants were assayed by a sandwich ELISA using the method supplied by PharMingen (San Diego, CA) and previously described 12) . The capture and detection mAbs pairs were as follows: IL-4, 8D4-8/MP4-25D2; IL-10, JES3-19F1/JES3-12G8; IFNγ, NIB42/4S.B3; TNFα, MAb1/MAb11.…”

Section: Determination Of Cytokine Concentrationmentioning

confidence: 99%

Immunotoxicological Effects of Agent Orange Exposure to the Vietnam War Korean Veterans.

Kim

Park

et al. 2003

INDUSTRIAL HEALTH

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Immunomodulatory effects of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) demonstrated using animals are thymic atrophy, downregulation of cytotoxic T or B lymphocyte differentiation or activation, whereas human immunotoxicities have not been investigated well. This study was undertaken to evaluate overall immunologic spectrum of the Vietnam War Korean veterans exposed to Agent Orange contaminated with TCDD. Quantity of red blood cells, hemoglobin and hematocrit in the veterans suffered from chronic diseases associated with Agent Orange exposure (Veteranspatient group) were decreased in comparison with those of the veterans without the diseases and the age-matched healthy controls, but no differences in leukocyte populations. Plasma IgG levels were lowered in the veterans than the controls, owing to significant decrease in the IgG1 levels. Increase in the IgE levels was observed in the plasma from the veterans. Alteration of T cell-mediated immunity was also resulted from activation of peripheral blood mononuclear cells with polyclonal T cell activators. Production of IFNγ γ γ γ γ, a major cytokine mediating host resistance against infection or tumoregenesis, was lowered in the veterans-patient group. However, production of IL-4 and IL-10, representative cytokines involved with hypersensitivity induction, was enhanced in the patient group. Overall, this study suggests that military service in Vietnam and/or Agent Orange exposure disturbs immune-homeostasis resulting in dysregulation of B and T cell activities.

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Section: Determination Of Cytokine Concentrationmentioning

confidence: 99%

Immunotoxicological Effects of Agent Orange Exposure to the Vietnam War Korean Veterans.

Kim

Park

et al. 2003

INDUSTRIAL HEALTH

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“…[35] The serum levels of IgG1, an Ig involved in host defence against many microbial infections, were significantly lower in the sera of Sb-exposed individuals than in the controls. The serum concentrations of IgE, an Ig mediating allergic hypersensitivity, were also lower in the Sb-exposed workers than in the controls.…”

Section: Resultsmentioning

confidence: 99%

“…The levels of interleukin-2 and interferon-gamma, multifunctional cytokines for T-cell-mediated immunity, were lowered in the factory workers. [35] A significant positive correlation between IgG4 and urine Sb levels was found among the Sb-exposed workers, indicating a possible role of IgG4 in Sb-mediated pulmonary or skin pathogenesis. [35] A study of exposure to antimony trioxide fumes in a brazing rod manufacturer resulted in a systemic eruption of follicular papules and pustules.…”

Section: Resultsmentioning

confidence: 99%

The exposure to and health effects of antimony

Cooper

Harrison

2009

Indian J Occup Environ Med

154

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Context:This minireview describes the health effects of antimony exposure in the workplace and the environment.Aim:To collate information on the consequences of occupational and environmental exposure to antimony on physiological function and well-being.Methods:The criteria used in the current minireview for selecting articles were adopted from proposed criteria in The International Classification of Functioning, Disability and Health. Articles were classified from an acute and chronic exposure and toxicity thrust.Results:The proportion of utilised and non-utilised articles was tabulated. Antimony toxicity is dependent on the exposure dose, duration, route (breathing, eating, drinking, or skin contact), other chemical exposures, age, sex, nutritional status, family traits, life style, and state of health. Chronic exposure to antimony in the air at levels of 9 mg/m3 may exacerbate irritation of the eyes, skin, and lungs. Long-term inhalation of antimony can potentiate pneumoconiosis, altered electrocardiograms, stomach pain, diarrhea, vomiting, and stomach ulcers, results which were confirmed in laboratory animals. Although there were investigations of the effect of antimony in sudden infant death syndrome, current findings suggest no link. Antimony trioxide exposure is predominant in smelters. Mining and exposure via glass working, soldering, and brazing are also important.Conclusion:Antimony has some useful but undoubtedly harmful effects on health and well-being and measures need to be taken to prevent hazardous exposure of the like. Its biological monitoring in the workplace is essential.

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“…Antimony (Sb) and its compounds are widely used in some industries, including alloy, plastic, glass, and textile industries [ 1 , 2 , 3 , 4 , 5 , 6 ]. The permissible exposure limit (PEL) established by the US Occupational Safety and Health Administration for exposure to antimony and compounds is 0.5 mg/m 3 of antimony in the workplace based on a working 8 h shift and a 40 h week [ 7 ].…”

Section: Introductionmentioning

confidence: 99%

Assessment of Industrial Antimony Exposure and Immunologic Function for Workers in Taiwan

Chen

2017

IJERPH

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This study investigated antimony exposure among employees in industries in Taiwan and evaluated whether their immunologic markers were associated with antimony exposure. We recruited 91 male workers and 42 male office administrators from 2 glass manufacturing plants, 1 antimony trioxide manufacturing plants, and 2 engineering plastic manufacturing plants. Air samples were collected at worksites and administrative offices, and each participant provided specimens of urine, blood, and hair to assay antimony levels. We also determined white blood cells, lymphocyte, and monocyte, IgA, IgE, and IgG in blood specimens. The mean antimony concentration in the air measured at worksites was much higher in the antimony trioxide plant (2.51 ± 0.57 mg/m3) than in plastic plants (0.21 ± 0.06 mg/m3) and glass plants (0.14 ± 0.01 mg/m3). Antimony levels in blood, urine, and hair measured for participants were correlated with worksites and were higher in workers than in administrators. The mean serum IgG, IgA, and IgE levels were lower in workers than in administrators (p < 0.001). Serum IgA and IgE levels in participants were negatively associated with antimony levels in air samples of workplaces, and in blood, urine, and hairs of participants. Serum IgG and IgE of all participants were also negatively associated with antimony levels in their hairs. In conclusion, the antimony exposure is greater for workers employed in the five industrial plants than for administrators. This study suggests serum IgG, IgA, and IgE levels are negatively associated with antimony exposure.

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Altered serum cytokine and immunoglobulin levels in the workers exposed to antimony

Cited by 33 publications

References 42 publications

Immunotoxicological Effects of Agent Orange Exposure to the Vietnam War Korean Veterans.

Immunotoxicological Effects of Agent Orange Exposure to the Vietnam War Korean Veterans.

The exposure to and health effects of antimony

Assessment of Industrial Antimony Exposure and Immunologic Function for Workers in Taiwan

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