Altered sodium perception in essential hypertensive patients following rapid volume expansion

Conlin, P. R.; Tl, Moore; Williams, G. H.; Nk, Hollenberg

doi:10.1038/sj.jhh.1000852

Cited by 2 publications

(2 citation statements)

References 14 publications

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“…Our results are qualitatively concordant with more recent investigations in humans and dogs which came to similar overall conclusions regarding the importance of the RAAS in the regulation of total body sodium (Singer et al 1991; Drummer et al 1992; Singer et al 1994; Andersen et al 1998; Conlin et al 1999; Andersen et al 2000; Bie & Sandgaard, 2000; Reinhardt & Seeliger, 2000; Sandgaard et al 2000). Taken together the results indicate that the initial natriuretic response may depend heavily on: (1) suppression of the RAAS, (2) the sodium status of the subjects, (3) the duration of infusion, and (4) the rate of infusion, but not on changes in blood pressure.…”

Section: Discussionsupporting

confidence: 93%

Mechanisms of acute natriuresis in normal humans on low sodium diet

Rasmussen

Simonsen

Sandgaard

et al. 2003

The Journal of Physiology

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This study evaluates the relative importance of several mechanisms possibly involved in the natriuresis elicited by slow sodium loading, i.e. the renin-angiotensin-aldosterone system (RAAS), mean arterial blood pressure (MAP), glomerular filtration rate (GFR), atrial natriuretic peptide (ANP), oxytocin and nitric oxide (NO). Eight seated subjects on standardised sodium intake (30 mmol NaCl day _1 ) received isotonic saline intravenously (NaLoading: 20 mmol Na + kg _1 min _1 or ~11 ml min _1 for 240 min). NaLoading did not change MAP or GFR (by clearance of 51 Cr-EDTA). Significant natriuresis occurred within 1 h (from 9 ± 3 to 13 ± 2 mmol min _1 ). A 6-fold increase was found during the last hour of infusion as plasma renin activity, angiotensin II (ANGII) and aldosterone decreased markedly. Sodium excretion continued to increase after NaLoading. During NaLoading, plasma renin activity and ANGII were linearly related (R = 0.997) as were ANGII and aldosterone (R = 0.999). The slopes were 0.40 pM ANGII (mi.u. renin activity) _1 and 22 pM aldosterone (pM ANGII) _1. Plasma ANP and oxytocin remained unchanged, as did the urinary excretion rates of cGMP and NO metabolites (NO x ). In conclusion, sodium excretion may increase 7-fold without changes in MAP, GFR, plasma ANP, plasma oxytocin, and cGMP-and NO x excretion, but concomitant with marked decreases in circulating RAAS components. The immediate renal response to sodium excess appears to be fading of ANGII-mediated tubular sodium reabsorption. Subsequently the decrease in aldosterone may become important.

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Section: Discussionsupporting

confidence: 93%

Mechanisms of acute natriuresis in normal humans on low sodium diet

Rasmussen

Simonsen

Sandgaard

et al. 2003

The Journal of Physiology

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“…Hypertension has been positively correlated with thirst (Shailendra et al, 2011); it was reported to increase thirst perception (Stachenfeld, 2008), stimulate RAAS (Atlas, 2007) and alter sodium perception (Conlin et al, 1999). But H. sabdariffa consumption was reported to reduce plasma aldosterone level (Nwachukwu et al, 2015b) and exert antihypertensive action in humans (Herrea-Arellano et al, 2004;McKay et al, 2010).…”

Section: Discussionmentioning

confidence: 99%

Thirst perception in mild to moderate hypertensive Nigerians treated with aqueous extract of Hibiscus sabdariffa L.

Daniel¹,

Eddy²,

Nkiru³

et al. 2016

Afr. J. Pharm. Pharmacol.

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Aqueous extract of Hibiscus sabdariffa L. is widely consumed in Nigeria as a local beverage used to quench thirst and also because of its antihypertensive action. The present study investigated the effect of consumption of aqueous extract of H. sabdariffa on thirst perception (TP) in mild to moderate hypertensive Nigerians. Fifty mild to moderate hypertensive patients attending medical out-patients clinic of Enugu State University Teaching Hospital were recruited for the study. They were randomly divided into two groups: A and B. Those in group A were given equivalent dose of placebo while group B received 150 mg/kg of H. sabdariffa daily for 4 weeks. All the subjects were given weekly appointments and a week worth of infusion. Thirst perception, serum electrolytes and blood pressure (BP) were measured at baseline and weekly during treatment. TP reduced significantly (p<0.001) in H. sabdariffa group compared to placebo throughout the duration of the experiment. Serum Na + reduced significantly (p<0.001) in H. sabdariffa compared to placebo group in weeks 3 and 4. Blood pressure (SBP, DBP and MAP) also reduced significantly (p<0.001) in weeks 3 and 4. Thus, consumption of H. sabdariffa reduced thirst perception in mild to moderate hypertensive Nigerians. This validates its traditional use to 'quench thirst' and complements its antihypertensive action. Reduction in serum Na + may be the possible mechanism of action.

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Altered sodium perception in essential hypertensive patients following rapid volume expansion

Cited by 2 publications

References 14 publications

Mechanisms of acute natriuresis in normal humans on low sodium diet

Mechanisms of acute natriuresis in normal humans on low sodium diet

Thirst perception in mild to moderate hypertensive Nigerians treated with aqueous extract of Hibiscus sabdariffa L.

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