2012
DOI: 10.1016/j.neuroimage.2011.08.049
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Altered spontaneous activity in Alzheimer's disease and mild cognitive impairment revealed by Regional Homogeneity

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Cited by 226 publications
(194 citation statements)
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References 79 publications
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“…Portions of the fMRI data in the present study have been used in our previous studies of regional homogeneity [34] , and (4) Parkinsonian syndromes, epilepsy, or other nervous system diseases that can influence cognitive function.…”
Section: Participants and Methodsmentioning
confidence: 99%
“…Portions of the fMRI data in the present study have been used in our previous studies of regional homogeneity [34] , and (4) Parkinsonian syndromes, epilepsy, or other nervous system diseases that can influence cognitive function.…”
Section: Participants and Methodsmentioning
confidence: 99%
“…First of all, we explored different brain functional networks by independent component analysis (ICA), considering the involvement of specific networks in FTD related to GRN [20]. More recently, a number of functional parameters has been used to study local properties of brain activity at rest, also in FTD related to GRN, like regional homogeneity (ReHo), to look at the coherence of focal resting state fluctuations [21], the fractional amplitude of low frequency fluctuation (fALFF, that describes the power of the signal in the low frequency range) [22], degree centrality (DC, that allows the study of the nodes that form the whole-brain network [23]), and the voxel homotopic connectivity (VMHC, as index of functional symmetry in resting-state brain activity) [24]. In the present work we have taken advantage of the multivariate approach as machine-learning classifier of MVPA: 1) to identify the most accurate functional and/or structural neuroimaging index to be used, and 2) to define the most accurate neuroimaging pattern to classify the different stages of the GRN disease.…”
Section: Introductionmentioning
confidence: 99%
“…Findings from our research group and other studies suggest that brain regions with altered ReHo in patients with aMCI are located in structures associated with the EM [3,19,41,56] and EF [4,6,37,57] networks and include regions such as the hippocampus, PCC/precuneus (PCu), right inferior parietal lobule (IPL), DLPFC, and ventromedial prefrontal cortex (VMPFC) [58][59][60][61]. Therefore, the present study computed ReHo values to identify regions with abnormal local connectivity in a group of aMCI patients relative to healthy controls (HC).…”
Section: Introductionmentioning
confidence: 60%